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Rhythm Pharmaceuticals, Inc.. (RYTM) Fundamental Analysis & AI Grade 2026

RYTM Nasdaq Pharmaceutical Preparations DE CIK: 0001649904
Updated This Month • Analysis: May 7, 2026 • SEC Data: 2026-03-31
Combined AI Grade
C
72% Confidence
N/A
C
72% Conf
Pending
Analysis scheduled

📊 RYTM Key Takeaways

Revenue: $60.1M
Net Margin: -92.6%
Free Cash Flow: $-45.1M
Current Ratio: 4.17x
Debt/Equity: 0.80x
EPS: $-0.83
AI Grade: C with 72% confidence
Rhythm Pharmaceuticals, Inc.. (RYTM) receives a C fundamental grade with 72% confidence from our AI analysis based on SEC 10-K filings. With revenue of $60.1M, net profit margin of -92.6%, and return on equity (ROE) of -45.3%, Rhythm Pharmaceuticals, Inc.. demonstrates mixed fundamentals in the Healthcare sector. Below is our complete RYTM stock analysis for 2026.

Is Rhythm Pharmaceuticals, Inc.. (RYTM) a Good Investment?

Claude

While Rhythm Pharmaceuticals demonstrates strong revenue growth (+45.8% YoY) and improving loss trajectory, the company faces critical cash runway constraints with $45.1M annual free cash burn against only $62.1M in cash, providing approximately 1.4 years of operations. Despite positive commercialization trends, the absence of operating profitability and persistent inability to cover interest from operations present material solvency risks that require near-term improvement or capital infusion.

Rhythm Pharmaceuticals, Inc.. Key Strengths (RYTM)

Claude
  • + Strong topline revenue growth of 45.8% YoY demonstrates commercial traction
  • + Improving loss profile with net loss declining 2.7% YoY and EPS improving 28.3% YoY
  • + Excellent liquidity position with 4.17x current ratio and 3.89x quick ratio

RYTM Stock Risks: Rhythm Pharmaceuticals, Inc.. Investment Risks

Claude
  • ! Critical cash runway constraint: negative $45.1M FCF against $62.1M cash (~1.4 years coverage)
  • ! Deeply unprofitable with -92.6% net margin and -87.1% operating margin, cannot service debt from operations
  • ! Significant debt burden of $98.3M with negative interest coverage ratio of -11.0x

Key Metrics to Watch

Claude
  • * Time to operating profitability and quarterly burn rate trajectory
  • * Revenue growth sustainability and gross margin expansion as volumes increase
  • * Cash balance depletion rate and any capital raise or financing announcements

Rhythm Pharmaceuticals, Inc.. (RYTM) Financial Metrics & Key Ratios

Revenue
$60.1M
Net Income
$-55.6M
EPS (Diluted)
$-0.83
Free Cash Flow
$-45.1M
Total Assets
$442.3M
Cash Position
$62.1M

💡 AI Analyst Insight

Strong liquidity with a 4.17x current ratio provides a solid financial cushion.

RYTM Profit Margin, ROE & Profitability Analysis

Gross Margin N/A
Operating Margin -87.1%
Net Margin -92.6%
ROE -45.3%
ROA -12.6%
FCF Margin -75.1%

RYTM vs Healthcare Sector: How Rhythm Pharmaceuticals, Inc.. Compares

How Rhythm Pharmaceuticals, Inc.. compares to Healthcare sector averages

Net Margin
RYTM -92.6%
vs
Sector Avg 12.0%
RYTM Sector
ROE
RYTM -45.3%
vs
Sector Avg 15.0%
RYTM Sector
Current Ratio
RYTM 4.2x
vs
Sector Avg 2.0x
RYTM Sector
Debt/Equity
RYTM 0.8x
vs
Sector Avg 0.6x
RYTM Sector

Sector benchmarks are approximate industry averages. Actual sector performance may vary.

Is Rhythm Pharmaceuticals, Inc.. Stock Overvalued? RYTM Valuation Analysis 2026

Based on fundamental analysis, Rhythm Pharmaceuticals, Inc.. shows some fundamental concerns relative to the Healthcare sector in 2026.

Return on Equity
-45.3%
Sector avg: 15%
Net Profit Margin
-92.6%
Sector avg: 12%
Revenue Growth
N/A
Year-over-year
Debt/Equity
0.80x
Sector avg: 0.6x

Note: This is a fundamental analysis based on SEC filings. For P/E ratio, price targets, and market-based valuation, consult financial data providers. This is not investment advice.

Rhythm Pharmaceuticals, Inc.. Balance Sheet: RYTM Debt, Cash & Liquidity

Current Ratio
4.17x
Quick Ratio
3.89x
Debt/Equity
0.80x
Debt/Assets
46.3%
Interest Coverage
-11.01x
Long-term Debt
$98.3M

RYTM Revenue & Earnings Growth: 5-Year Financial Trend

RYTM 5-year financial data: Year 2023: Revenue $77.4M, Net Income -$69.6M, EPS $-1.40. Year 2024: Revenue $130.1M, Net Income -$181.1M, EPS $-3.20. Year 2025: Revenue $189.8M, Net Income -$184.7M, EPS $-3.20.
Revenue
Net Income
EPS (right axis)

5-Year Trend Summary: Rhythm Pharmaceuticals, Inc..'s revenue has grown significantly by 145% over the 5-year period, indicating strong business expansion. The most recent EPS of $-3.20 indicates the company is currently unprofitable.

RYTM Revenue Growth, EPS Growth & YoY Performance

Revenue Growth
N/A
Year-over-year
Net Income Growth
N/A
Year-over-year
EPS Growth
N/A
Earnings per share
FCF Margin
-75.1%
Free cash flow / Revenue

RYTM Quarterly Earnings & Performance

Quarterly financial performance data for Rhythm Pharmaceuticals, Inc.. including revenue, net income, and earnings per share.
Quarter Revenue Net Income EPS
Q1 2026 $32.7M -$49.5M $-0.81
Q3 2025 $33.3M -$32.3M $-0.73
Q2 2025 $29.1M -$32.3M $-0.55
Q1 2025 $26.0M -$49.5M $-0.81
Q3 2024 $22.5M -$32.3M $-0.73

Data sourced from SEC EDGAR 10-Q quarterly filings. Figures may represent quarterly or cumulative values.

Rhythm Pharmaceuticals, Inc.. Dividends, Buybacks & Capital Allocation

Operating Cash Flow
-$44.2M
Cash generated from operations
Capital Expenditures
$953.0K
Investment in assets
Dividends
None
No dividend program

RYTM SEC Filings: Latest 10-K & 10-Q Analysis

Access official SEC EDGAR filings for Rhythm Pharmaceuticals, Inc.. (CIK: 0001649904)

📋 Recent SEC Filings

Date Form Document Action
May 20, 2026 4 xslF345X06/tm2615222-1_4seq1.xml View →
May 19, 2026 4 xslF345X06/tm2615084-1_4seq1.xml View →
May 5, 2026 10-Q rytm-20260331.htm View →
May 5, 2026 8-K rytm-20260505.htm View →
Apr 29, 2026 DEF 14A rytm-20260429.htm View →

Frequently Asked Questions about RYTM

What is the AI rating for RYTM?

Rhythm Pharmaceuticals, Inc.. (RYTM) has an AI grade of C with 72% confidence, based on fundamental analysis of SEC EDGAR filings.

What are RYTM's key strengths?

Claude: Strong topline revenue growth of 45.8% YoY demonstrates commercial traction. Improving loss profile with net loss declining 2.7% YoY and EPS improving 28.3% YoY.

What are the risks of investing in RYTM?

Claude: Critical cash runway constraint: negative $45.1M FCF against $62.1M cash (~1.4 years coverage). Deeply unprofitable with -92.6% net margin and -87.1% operating margin, cannot service debt from operations.

What is RYTM's revenue and growth?

Rhythm Pharmaceuticals, Inc.. reported revenue of $60.1M.

Does RYTM pay dividends?

Rhythm Pharmaceuticals, Inc.. does not currently pay dividends.

Where can I find RYTM SEC filings?

Official SEC filings for Rhythm Pharmaceuticals, Inc.. (CIK: 0001649904) including 10-K, 10-Q, and 8-K reports are available on SEC EDGAR.

What is RYTM's EPS?

Rhythm Pharmaceuticals, Inc.. has a diluted EPS of $-0.83.

How is the AI analysis conducted?

Two independent AI systems — Claude (Anthropic) and ChatGPT (OpenAI) — analyze SEC EDGAR filings including 10-K annual reports and 10-Q quarterly reports. Each AI evaluates financial health, profitability ratios, balance sheet strength, and growth metrics. The combined grade reflects both perspectives for balanced insights.

What is RYTM's fundamental grade?

Based on our AI fundamental analysis in May 2026, Rhythm Pharmaceuticals, Inc.. has a C grade with 72% confidence. Review the strengths and risks sections above for full context. This is not investment advice.

Is RYTM stock overvalued or undervalued?

Valuation metrics for RYTM: ROE of -45.3% (sector avg: 15%), net margin of -92.6% (sector avg: 12%). Compare these metrics with sector averages to assess valuation.

What is RYTM's AI grade for 2026?

Our dual AI analysis gives Rhythm Pharmaceuticals, Inc.. a combined C grade for 2026. Revenue is data pending, with profitability at or below sector average. Always conduct your own research.

What is RYTM's free cash flow?

Rhythm Pharmaceuticals, Inc..'s operating cash flow is $-44.2M, with capital expenditures of $953.0K. FCF margin is -75.1%.

How does RYTM compare to other Healthcare stocks?

Vs Healthcare sector averages: Net margin -92.6% (avg: 12%), ROE -45.3% (avg: 15%), current ratio 4.17 (avg: 2).

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Disclaimer: This analysis is generated by Claude AI (Anthropic) and ChatGPT (OpenAI) based on publicly available SEC EDGAR filings. It does not include stock price data and should not be considered financial advice. All fundamental data is sourced from SEC public domain filings. Always conduct your own research and consult with a qualified financial advisor before making investment decisions.
Data Source: SEC EDGAR | Analysis Date: May 7, 2026 | Data as of: 2026-03-31 | Powered by Claude AI