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Pliant Therapeutics, Inc.. (PLRX) Stock Fundamental Analysis & AI Rating 2026

PLRX Nasdaq Pharmaceutical Preparations DE CIK: 0001746473
Recently Updated • Analysis: Apr 14, 2026 • SEC Data: 2025-12-31
STRONG SELL
68% Conf
Pending
Analysis scheduled

📊 PLRX Key Takeaways

Revenue: $0.0
Net Margin: N/A
Free Cash Flow: $-128.7M
Current Ratio: 12.00x
Debt/Equity: 0.00x
EPS: $-2.43
AI Rating: STRONG SELL with 68% confidence
Pliant Therapeutics, Inc.. (PLRX) receives a STRONG SELL rating with 68% confidence from our AI fundamental analysis based on SEC 10-K filings. With revenue of $0, and return on equity (ROE) of -82.4%, Pliant Therapeutics, Inc.. demonstrates mixed fundamentals in the Healthcare sector. Below is our complete PLRX stock analysis for 2026.

Is Pliant Therapeutics, Inc.. (PLRX) a Good Investment?

Claude

Pliant Therapeutics is a pre-commercial stage pharmaceutical company with zero revenue and approximately 4-5 months of cash runway at current $128.3M annual burn rates, creating critical near-term capital requirement risk. While year-over-year loss improvements (29% better net income, 30% better EPS) and zero debt demonstrate operational progress, the fundamental mismatch between $45.4M cash reserves and accelerating burn rate necessitates an urgent capital raise with significant dilution risk to existing shareholders.

Why Buy Pliant Therapeutics, Inc.. Stock? PLRX Key Strengths

Claude
  • + Net loss and EPS improving year-over-year indicating operational efficiency gains or reduced spend
  • + Zero long-term debt and strong relative balance sheet with $181.2M stockholders equity and no leverage
  • + Exceptional short-term liquidity with 12.0x current and quick ratios providing flexibility for near-term obligations

PLRX Stock Risks: Pliant Therapeutics, Inc.. Investment Risks

Claude
  • ! Zero revenue indicating pre-commercial stage with binary outcome risk dependent entirely on clinical/regulatory success
  • ! Critical cash runway of only 4-5 months at current burn rate requiring dilutive capital raise within quarters
  • ! Substantial operating cash burn of $128.3M annually against limited assets, indicating unsustainable burn trajectory without revenue inflection

Key Metrics to Watch

Claude
  • * Quarterly cash burn rate and remaining cash position relative to operating runway
  • * Clinical trial advancement, regulatory milestone achievements, and potential commercialization timelines
  • * Capital raise announcements, financing terms, and shareholder dilution from equity issuance

Pliant Therapeutics, Inc.. (PLRX) Financial Metrics & Key Ratios

Revenue
$0.0
Net Income
$-149.3M
EPS (Diluted)
$-2.43
Free Cash Flow
$-128.7M
Total Assets
$225.2M
Cash Position
$45.4M

💡 AI Analyst Insight

Strong liquidity with a 12.00x current ratio provides a solid financial cushion.

PLRX Profit Margin, ROE & Profitability Analysis

Gross Margin N/A
Operating Margin N/A
Net Margin N/A
ROE -82.4%
ROA -66.3%
FCF Margin N/A

PLRX vs Healthcare Sector: How Pliant Therapeutics, Inc.. Compares

How Pliant Therapeutics, Inc.. compares to Healthcare sector averages

Net Margin
PLRX 0.0%
vs
Sector Avg 12.0%
PLRX Sector
ROE
PLRX -82.4%
vs
Sector Avg 15.0%
PLRX Sector
Current Ratio
PLRX 12.0x
vs
Sector Avg 2.0x
PLRX Sector
Debt/Equity
PLRX 0.0x
vs
Sector Avg 0.6x
PLRX Sector

Sector benchmarks are approximate industry averages. Actual sector performance may vary.

Is Pliant Therapeutics, Inc.. Stock Overvalued? PLRX Valuation Analysis 2026

Based on fundamental analysis, Pliant Therapeutics, Inc.. has mixed fundamental signals relative to the Healthcare sector in 2026.

Return on Equity
-82.4%
Sector avg: 15%
Net Profit Margin
N/A
Sector avg: 12%
Revenue Growth
N/A
Year-over-year
Debt/Equity
0.00x
Sector avg: 0.6x

Note: This is a fundamental analysis based on SEC filings. For P/E ratio, price targets, and market-based valuation, consult financial data providers. This is not investment advice.

Pliant Therapeutics, Inc.. Balance Sheet: PLRX Debt, Cash & Liquidity

Current Ratio
12.00x
Quick Ratio
12.00x
Debt/Equity
0.00x
Debt/Assets
19.5%
Interest Coverage
-351.40x
Long-term Debt
$0.0

PLRX Revenue & Earnings Growth: 5-Year Financial Trend

PLRX 5-year financial data: Year 2021: Revenue $57.1M, Net Income -$631.0K, EPS $-4.22. Year 2022: Revenue $9.7M, Net Income -$97.3M, EPS $-2.71. Year 2023: Revenue $9.7M, Net Income -$97.3M, EPS $-2.71. Year 2024: Revenue $9.7M, Net Income -$123.3M, EPS $-2.94. Year 2025: Revenue $0, Net Income -$210.3M, EPS $-3.47.
Revenue
Net Income
EPS (right axis)

5-Year Trend Summary: Pliant Therapeutics, Inc..'s revenue has declined by 100% over the 5-year period, indicating business contraction. The most recent EPS of $-3.47 indicates the company is currently unprofitable.

PLRX Revenue Growth, EPS Growth & YoY Performance

Revenue Growth
N/A
Year-over-year
Net Income Growth
N/A
Year-over-year
EPS Growth
N/A
Earnings per share
FCF Margin
N/A
Free cash flow / Revenue

PLRX Quarterly Earnings & Performance

Quarterly financial performance data for Pliant Therapeutics, Inc.. including revenue, net income, and earnings per share.
Quarter Revenue Net Income EPS
Q3 2024 N/A -$37.5M $-0.70
Q2 2024 N/A -$37.5M $-0.70
Q1 2024 N/A -$37.5M $-0.67
Q3 2023 N/A -$28.1M $-0.65
Q2 2023 $248.0K -$28.1M $-0.70
Q1 2023 $1.2M -$28.1M $-0.67
Q3 2022 $1.5M -$22.8M $-0.65
Q2 2022 $1.8M -$22.8M $-0.64

Data sourced from SEC EDGAR 10-Q quarterly filings. Figures may represent quarterly or cumulative values.

Pliant Therapeutics, Inc.. Dividends, Buybacks & Capital Allocation

Operating Cash Flow
-$128.3M
Cash generated from operations
Capital Expenditures
$374.0K
Investment in assets
Dividends
None
No dividend program

PLRX SEC Filings: Latest 10-K & 10-Q Analysis

Access official SEC EDGAR filings for Pliant Therapeutics, Inc.. (CIK: 0001746473)

📋 Recent SEC Filings

Date Form Document Action
Mar 30, 2026 8-K plrx-20260327.htm View →
Mar 11, 2026 8-K plrx-20260311.htm View →
Mar 11, 2026 10-K plrx-20251231.htm View →
Mar 3, 2026 8-K plrx-20260303.htm View →
Jan 26, 2026 4 xslF345X05/wk-form4_1769463411.xml View →

Frequently Asked Questions about PLRX

What is the AI rating for PLRX?

Pliant Therapeutics, Inc.. (PLRX) has an AI rating of STRONG SELL with 68% confidence, based on fundamental analysis of SEC EDGAR filings.

What are PLRX's key strengths?

Claude: Net loss and EPS improving year-over-year indicating operational efficiency gains or reduced spend. Zero long-term debt and strong relative balance sheet with $181.2M stockholders equity and no leverage.

What are the risks of investing in PLRX?

Claude: Zero revenue indicating pre-commercial stage with binary outcome risk dependent entirely on clinical/regulatory success. Critical cash runway of only 4-5 months at current burn rate requiring dilutive capital raise within quarters.

What is PLRX's revenue and growth?

Pliant Therapeutics, Inc.. reported revenue of $0.0.

Does PLRX pay dividends?

Pliant Therapeutics, Inc.. does not currently pay dividends.

Where can I find PLRX SEC filings?

Official SEC filings for Pliant Therapeutics, Inc.. (CIK: 0001746473) including 10-K, 10-Q, and 8-K reports are available on SEC EDGAR.

What is PLRX's EPS?

Pliant Therapeutics, Inc.. has a diluted EPS of $-2.43.

How is the AI analysis conducted?

Two independent AI systems — Claude (Anthropic) and ChatGPT (OpenAI) — analyze SEC EDGAR filings including 10-K annual reports and 10-Q quarterly reports. Each AI evaluates financial health, profitability ratios, balance sheet strength, and growth metrics. The combined rating reflects both perspectives for balanced insights.

Is PLRX a good stock to buy right now?

Based on our AI fundamental analysis in April 2026, Pliant Therapeutics, Inc.. has a STRONG SELL rating with 68% confidence. Review the strengths and risks sections above before making a decision. This is not investment advice.

Is PLRX stock overvalued or undervalued?

Valuation metrics for PLRX: ROE of -82.4% (sector avg: 15%), net margin of N/A (sector avg: 12%). Compare these metrics with sector averages to assess valuation.

Should I buy PLRX stock in 2026?

Our dual AI analysis gives Pliant Therapeutics, Inc.. a combined STRONG SELL rating for 2026. Revenue is data pending, with profitability at or below sector average. Always conduct your own research.

What is PLRX's free cash flow?

Pliant Therapeutics, Inc..'s operating cash flow is $-128.3M, with capital expenditures of $374.0K.

How does PLRX compare to other Healthcare stocks?

Vs Healthcare sector averages: Net margin N/A (avg: 12%), ROE -82.4% (avg: 15%), current ratio 12.00 (avg: 2).

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Disclaimer: This analysis is generated by Claude AI (Anthropic) and ChatGPT (OpenAI) based on publicly available SEC EDGAR filings. It does not include stock price data and should not be considered financial advice. All fundamental data is sourced from SEC public domain filings. Always conduct your own research and consult with a qualified financial advisor before making investment decisions.
Data Source: SEC EDGAR | Analysis Date: Apr 14, 2026 | Data as of: 2025-12-31 | Powered by Claude AI