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Pliant Therapeutics, Inc.. (PLRX) Fundamental Analysis & AI Grade 2026

PLRX Nasdaq Pharmaceutical Preparations DE CIK: 0001746473
Updated This Month • Analysis: May 16, 2026 • SEC Data: 2026-03-31
Combined AI Grade
B
70% Confidence
N/A
B
70% Conf
Pending
Analysis scheduled

📊 PLRX Key Takeaways

Revenue: $0.0
Net Margin: N/A
Free Cash Flow: $-19.2M
Current Ratio: 16.89x
Debt/Equity: 0.00x
EPS: $-0.32
AI Grade: B with 70% confidence
Pliant Therapeutics, Inc.. (PLRX) receives a B fundamental grade with 70% confidence from our AI analysis based on SEC 10-K filings. With revenue of $0, and return on equity (ROE) of -12.1%, Pliant Therapeutics, Inc.. demonstrates mixed fundamentals in the Healthcare sector. Below is our complete PLRX stock analysis for 2026.

Is Pliant Therapeutics, Inc.. (PLRX) a Good Investment?

Claude

Pliant Therapeutics exhibits a reasonably healthy balance sheet with strong liquidity and zero debt, but faces critical execution risk as a pre-revenue pharmaceutical company burning approximately $19.2M annually with only ~1.2 years of cash runway. Success depends entirely on clinical development progress and future financing or revenue generation.

Pliant Therapeutics, Inc.. Key Strengths (PLRX)

Claude
  • + Strong balance sheet with $165.2M stockholders' equity and minimal liabilities of $37.4M
  • + Excellent liquidity position with 16.89x current ratio and $22.2M cash reserves; zero long-term debt
  • + Improving EPS metrics year-over-year (+30%) suggests better operational efficiency or reduced share dilution

PLRX Stock Risks: Pliant Therapeutics, Inc.. Investment Risks

Claude
  • ! Limited cash runway of approximately 1.2 years at current burn rate of $19.2M annually
  • ! Zero revenue indicates pre-commercialization stage with no validated business model or clinical success achieved
  • ! Negative operating cash flow will likely require significant future capital raises, creating substantial shareholder dilution risk

Key Metrics to Watch

Claude
  • * Quarterly cash burn rate and remaining months of cash runway; trajectory of operating cash flow
  • * Clinical trial progress and regulatory milestones for pharmaceutical pipeline programs
  • * Capital structure changes including equity or debt financing announcements

Pliant Therapeutics, Inc.. (PLRX) Financial Metrics & Key Ratios

Revenue
$0.0
Net Income
$-20.0M
EPS (Diluted)
$-0.32
Free Cash Flow
$-19.2M
Total Assets
$202.6M
Cash Position
$22.2M

💡 AI Analyst Insight

Strong liquidity with a 16.89x current ratio provides a solid financial cushion.

PLRX Profit Margin, ROE & Profitability Analysis

Gross Margin N/A
Operating Margin N/A
Net Margin N/A
ROE -12.1%
ROA -9.9%
FCF Margin N/A

PLRX vs Healthcare Sector: How Pliant Therapeutics, Inc.. Compares

How Pliant Therapeutics, Inc.. compares to Healthcare sector averages

Net Margin
PLRX 0.0%
vs
Sector Avg 12.0%
PLRX Sector
ROE
PLRX -12.1%
vs
Sector Avg 15.0%
PLRX Sector
Current Ratio
PLRX 16.9x
vs
Sector Avg 2.0x
PLRX Sector
Debt/Equity
PLRX 0.0x
vs
Sector Avg 0.6x
PLRX Sector

Sector benchmarks are approximate industry averages. Actual sector performance may vary.

Is Pliant Therapeutics, Inc.. Stock Overvalued? PLRX Valuation Analysis 2026

Based on fundamental analysis, Pliant Therapeutics, Inc.. has mixed fundamental signals relative to the Healthcare sector in 2026.

Return on Equity
-12.1%
Sector avg: 15%
Net Profit Margin
N/A
Sector avg: 12%
Revenue Growth
N/A
Year-over-year
Debt/Equity
0.00x
Sector avg: 0.6x

Note: This is a fundamental analysis based on SEC filings. For P/E ratio, price targets, and market-based valuation, consult financial data providers. This is not investment advice.

Pliant Therapeutics, Inc.. Balance Sheet: PLRX Debt, Cash & Liquidity

Current Ratio
16.89x
Quick Ratio
16.89x
Debt/Equity
0.00x
Debt/Assets
18.5%
Interest Coverage
-48.93x
Long-term Debt
$0.0

PLRX Revenue & Earnings Growth: 5-Year Financial Trend

PLRX 5-year financial data: Year 2021: Revenue $57.1M, Net Income -$631.0K, EPS $-4.22. Year 2022: Revenue $9.7M, Net Income -$97.3M, EPS $-2.71. Year 2023: Revenue $9.7M, Net Income -$97.3M, EPS $-2.71. Year 2024: Revenue $9.7M, Net Income -$123.3M, EPS $-2.94. Year 2025: Revenue $0, Net Income -$210.3M, EPS $-3.47.
Revenue
Net Income
EPS (right axis)

5-Year Trend Summary: Pliant Therapeutics, Inc..'s revenue has declined by 100% over the 5-year period, indicating business contraction. The most recent EPS of $-3.47 indicates the company is currently unprofitable.

PLRX Revenue Growth, EPS Growth & YoY Performance

Revenue Growth
N/A
Year-over-year
Net Income Growth
N/A
Year-over-year
EPS Growth
N/A
Earnings per share
FCF Margin
N/A
Free cash flow / Revenue

PLRX Quarterly Earnings & Performance

Quarterly financial performance data for Pliant Therapeutics, Inc.. including revenue, net income, and earnings per share.
Quarter Revenue Net Income EPS
Q3 2024 N/A -$37.5M $-0.70
Q2 2024 N/A -$37.5M $-0.70
Q1 2024 N/A -$37.5M $-0.67
Q3 2023 N/A -$28.1M $-0.65
Q2 2023 $248.0K -$28.1M $-0.70
Q1 2023 $1.2M -$28.1M $-0.67
Q3 2022 $1.5M -$22.8M $-0.65
Q2 2022 $1.8M -$22.8M $-0.64

Data sourced from SEC EDGAR 10-Q quarterly filings. Figures may represent quarterly or cumulative values.

Pliant Therapeutics, Inc.. Dividends, Buybacks & Capital Allocation

Operating Cash Flow
-$19.2M
Cash generated from operations
Dividends
None
No dividend program

PLRX SEC Filings: Latest 10-K & 10-Q Analysis

Access official SEC EDGAR filings for Pliant Therapeutics, Inc.. (CIK: 0001746473)

📋 Recent SEC Filings

Date Form Document Action
May 11, 2026 10-Q plrx-20260331.htm View →
May 11, 2026 8-K plrx-20260511.htm View →
Apr 22, 2026 DEF 14A plrx-20260422.htm View →
Apr 17, 2026 4 xslF345X06/wk-form4_1776458567.xml View →
Apr 17, 2026 4 xslF345X06/wk-form4_1776458561.xml View →

Frequently Asked Questions about PLRX

What is the AI rating for PLRX?

Pliant Therapeutics, Inc.. (PLRX) has an AI grade of B with 70% confidence, based on fundamental analysis of SEC EDGAR filings.

What are PLRX's key strengths?

Claude: Strong balance sheet with $165.2M stockholders' equity and minimal liabilities of $37.4M. Excellent liquidity position with 16.89x current ratio and $22.2M cash reserves; zero long-term debt.

What are the risks of investing in PLRX?

Claude: Limited cash runway of approximately 1.2 years at current burn rate of $19.2M annually. Zero revenue indicates pre-commercialization stage with no validated business model or clinical success achieved.

What is PLRX's revenue and growth?

Pliant Therapeutics, Inc.. reported revenue of $0.0.

Does PLRX pay dividends?

Pliant Therapeutics, Inc.. does not currently pay dividends.

Where can I find PLRX SEC filings?

Official SEC filings for Pliant Therapeutics, Inc.. (CIK: 0001746473) including 10-K, 10-Q, and 8-K reports are available on SEC EDGAR.

What is PLRX's EPS?

Pliant Therapeutics, Inc.. has a diluted EPS of $-0.32.

How is the AI analysis conducted?

Two independent AI systems — Claude (Anthropic) and ChatGPT (OpenAI) — analyze SEC EDGAR filings including 10-K annual reports and 10-Q quarterly reports. Each AI evaluates financial health, profitability ratios, balance sheet strength, and growth metrics. The combined grade reflects both perspectives for balanced insights.

What is PLRX's fundamental grade?

Based on our AI fundamental analysis in May 2026, Pliant Therapeutics, Inc.. has a B grade with 70% confidence. Review the strengths and risks sections above for full context. This is not investment advice.

Is PLRX stock overvalued or undervalued?

Valuation metrics for PLRX: ROE of -12.1% (sector avg: 15%), net margin of N/A (sector avg: 12%). Compare these metrics with sector averages to assess valuation.

What is PLRX's AI grade for 2026?

Our dual AI analysis gives Pliant Therapeutics, Inc.. a combined B grade for 2026. Revenue is data pending, with profitability at or below sector average. Always conduct your own research.

What is PLRX's free cash flow?

Pliant Therapeutics, Inc..'s operating cash flow is $-19.2M, with capital expenditures of $0.0.

How does PLRX compare to other Healthcare stocks?

Vs Healthcare sector averages: Net margin N/A (avg: 12%), ROE -12.1% (avg: 15%), current ratio 16.89 (avg: 2).

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Disclaimer: This analysis is generated by Claude AI (Anthropic) and ChatGPT (OpenAI) based on publicly available SEC EDGAR filings. It does not include stock price data and should not be considered financial advice. All fundamental data is sourced from SEC public domain filings. Always conduct your own research and consult with a qualified financial advisor before making investment decisions.
Data Source: SEC EDGAR | Analysis Date: May 16, 2026 | Data as of: 2026-03-31 | Powered by Claude AI