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Phio Pharmaceuticals Corp. (PHIO) Stock Fundamental Analysis & AI Rating 2026

PHIO Nasdaq Pharmaceutical Preparations DE CIK: 0001533040
Recently Updated • Analysis: Apr 14, 2026 • SEC Data: 2025-12-31
SELL
65% Conf
Pending
Analysis scheduled

📊 PHIO Key Takeaways

Revenue: $231.0K
Net Margin: -3,765.4%
Free Cash Flow: $-8.0M
Current Ratio: 17.81x
Debt/Equity: 0.00x
EPS: $-0.86
AI Rating: SELL with 65% confidence
Phio Pharmaceuticals Corp. (PHIO) receives a SELL rating with 65% confidence from our AI fundamental analysis based on SEC 10-K filings. With revenue of $231.0K, net profit margin of -3,765.4%, and return on equity (ROE) of -43.2%, Phio Pharmaceuticals Corp. demonstrates mixed fundamentals in the Healthcare sector. Below is our complete PHIO stock analysis for 2026.

Is Phio Pharmaceuticals Corp. (PHIO) a Good Investment?

Claude

Phio operates as an early-stage pharmaceutical company with minimal revenue ($231K) while burning $8M annually in operating cash flow, creating significant execution risk despite improving loss metrics YoY. With approximately 2.5 years of cash runway at current burn rates, the company must demonstrate near-term revenue acceleration or cost reduction to achieve profitability before capital depletion.

Why Buy Phio Pharmaceuticals Corp. Stock? PHIO Key Strengths

Claude
  • + Exceptional balance sheet strength with $21M cash, zero long-term debt, and $1.3M total liabilities
  • + Outstanding liquidity position with 17.81x current ratio providing substantial operational flexibility
  • + Improving loss trajectory with net loss declining 21.7% YoY and EPS improving 80.6% YoY

PHIO Stock Risks: Phio Pharmaceuticals Corp. Investment Risks

Claude
  • ! Deeply unprofitable operations with operating margin of -3991.3% and net margin of -3765.4% indicating massive operational losses
  • ! Negative operating cash flow of -$8M annually with revenue of only $231K suggesting pre-commercial or failed commercialization stage
  • ! Limited cash runway of approximately 2.5 years at current burn rate with unproven path to profitability or financing capability

Key Metrics to Watch

Claude
  • * Revenue growth trajectory and timeline to commercial product revenue generation
  • * Operating cash burn rate and trend in cash consumption relative to clinical milestones
  • * Monthly cash burn rate reduction and achievement of non-dilutive funding sources

Phio Pharmaceuticals Corp. (PHIO) Financial Metrics & Key Ratios

Revenue
$231.0K
Net Income
$-8.7M
EPS (Diluted)
$-0.86
Free Cash Flow
$-8.0M
Total Assets
$21.5M
Cash Position
$21.0M

💡 AI Analyst Insight

Strong liquidity with a 17.81x current ratio provides a solid financial cushion.

PHIO Profit Margin, ROE & Profitability Analysis

Gross Margin N/A
Operating Margin -3,991.3%
Net Margin -3,765.4%
ROE -43.2%
ROA -40.5%
FCF Margin -3,459.3%

PHIO vs Healthcare Sector: How Phio Pharmaceuticals Corp. Compares

How Phio Pharmaceuticals Corp. compares to Healthcare sector averages

Net Margin
PHIO -3,765.4%
vs
Sector Avg 12.0%
PHIO Sector
ROE
PHIO -43.2%
vs
Sector Avg 15.0%
PHIO Sector
Current Ratio
PHIO 17.8x
vs
Sector Avg 2.0x
PHIO Sector
Debt/Equity
PHIO 0.0x
vs
Sector Avg 0.6x
PHIO Sector

Sector benchmarks are approximate industry averages. Actual sector performance may vary.

Is Phio Pharmaceuticals Corp. Stock Overvalued? PHIO Valuation Analysis 2026

Based on fundamental analysis, Phio Pharmaceuticals Corp. has mixed fundamental signals relative to the Healthcare sector in 2026.

Return on Equity
-43.2%
Sector avg: 15%
Net Profit Margin
-3,765.4%
Sector avg: 12%
Revenue Growth
N/A
Year-over-year
Debt/Equity
0.00x
Sector avg: 0.6x

Note: This is a fundamental analysis based on SEC filings. For P/E ratio, price targets, and market-based valuation, consult financial data providers. This is not investment advice.

Phio Pharmaceuticals Corp. Balance Sheet: PHIO Debt, Cash & Liquidity

Current Ratio
17.81x
Quick Ratio
17.81x
Debt/Equity
0.00x
Debt/Assets
6.2%
Interest Coverage
N/A
Long-term Debt
$0.0

PHIO Revenue & Earnings Growth: 5-Year Financial Trend

PHIO 5-year financial data: Year 2016: Revenue $34.0K, Net Income N/A, EPS N/A. Year 2017: Revenue $19.0K, Net Income N/A, EPS N/A. Year 2018: Revenue $138.0K, Net Income N/A, EPS N/A. Year 2019: Revenue $138.0K, Net Income N/A, EPS N/A. Year 2020: Revenue $21.0K, Net Income N/A, EPS N/A.
Revenue
Net Income
EPS (right axis)

5-Year Trend Summary: Phio Pharmaceuticals Corp.'s revenue has declined by 38% over the 5-year period, indicating business contraction. The most recent EPS of $-46.76 indicates the company is currently unprofitable.

PHIO Revenue Growth, EPS Growth & YoY Performance

Revenue Growth
N/A
Year-over-year
Net Income Growth
N/A
Year-over-year
EPS Growth
N/A
Earnings per share
FCF Margin
-3,459.3%
Free cash flow / Revenue

PHIO Quarterly Earnings & Performance

Quarterly financial performance data for Phio Pharmaceuticals Corp. including revenue, net income, and earnings per share.
Quarter Revenue Net Income EPS
Q3 2020 N/A -$1.7M N/A
Q2 2020 N/A -$1.7M N/A
Q1 2020 N/A -$2.1M N/A
Q3 2019 N/A -$1.5M N/A
Q2 2019 N/A -$1.9M N/A
Q1 2019 $21.0K -$2.1M N/A
Q3 2018 N/A -$1.5M N/A
Q2 2018 N/A -$1.9M N/A

Data sourced from SEC EDGAR 10-Q quarterly filings. Figures may represent quarterly or cumulative values.

Phio Pharmaceuticals Corp. Dividends, Buybacks & Capital Allocation

Operating Cash Flow
-$8.0M
Cash generated from operations
Capital Expenditures
$12.0K
Investment in assets
Dividends
None
No dividend program

PHIO SEC Filings: Latest 10-K & 10-Q Analysis

Access official SEC EDGAR filings for Phio Pharmaceuticals Corp. (CIK: 0001533040)

📋 Recent SEC Filings

Date Form Document Action
Apr 8, 2026 8-K phio20260402_8k.htm View →
Mar 30, 2026 8-K phio20260326_8k.htm View →
Mar 5, 2026 10-K phio20251231_10k.htm View →
Mar 5, 2026 8-K phio20251215_8k.htm View →
Feb 18, 2026 8-K phio20260216_8k.htm View →

Frequently Asked Questions about PHIO

What is the AI rating for PHIO?

Phio Pharmaceuticals Corp. (PHIO) has an AI rating of SELL with 65% confidence, based on fundamental analysis of SEC EDGAR filings.

What are PHIO's key strengths?

Claude: Exceptional balance sheet strength with $21M cash, zero long-term debt, and $1.3M total liabilities. Outstanding liquidity position with 17.81x current ratio providing substantial operational flexibility.

What are the risks of investing in PHIO?

Claude: Deeply unprofitable operations with operating margin of -3991.3% and net margin of -3765.4% indicating massive operational losses. Negative operating cash flow of -$8M annually with revenue of only $231K suggesting pre-commercial or failed commercialization stage.

What is PHIO's revenue and growth?

Phio Pharmaceuticals Corp. reported revenue of $231.0K.

Does PHIO pay dividends?

Phio Pharmaceuticals Corp. does not currently pay dividends.

Where can I find PHIO SEC filings?

Official SEC filings for Phio Pharmaceuticals Corp. (CIK: 0001533040) including 10-K, 10-Q, and 8-K reports are available on SEC EDGAR.

What is PHIO's EPS?

Phio Pharmaceuticals Corp. has a diluted EPS of $-0.86.

How is the AI analysis conducted?

Two independent AI systems — Claude (Anthropic) and ChatGPT (OpenAI) — analyze SEC EDGAR filings including 10-K annual reports and 10-Q quarterly reports. Each AI evaluates financial health, profitability ratios, balance sheet strength, and growth metrics. The combined rating reflects both perspectives for balanced insights.

Is PHIO a good stock to buy right now?

Based on our AI fundamental analysis in April 2026, Phio Pharmaceuticals Corp. has a SELL rating with 65% confidence. Review the strengths and risks sections above before making a decision. This is not investment advice.

Is PHIO stock overvalued or undervalued?

Valuation metrics for PHIO: ROE of -43.2% (sector avg: 15%), net margin of -3,765.4% (sector avg: 12%). Compare these metrics with sector averages to assess valuation.

Should I buy PHIO stock in 2026?

Our dual AI analysis gives Phio Pharmaceuticals Corp. a combined SELL rating for 2026. Revenue is data pending, with profitability at or below sector average. Always conduct your own research.

What is PHIO's free cash flow?

Phio Pharmaceuticals Corp.'s operating cash flow is $-8.0M, with capital expenditures of $12.0K. FCF margin is -3,459.3%.

How does PHIO compare to other Healthcare stocks?

Vs Healthcare sector averages: Net margin -3,765.4% (avg: 12%), ROE -43.2% (avg: 15%), current ratio 17.81 (avg: 2).

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Disclaimer: This analysis is generated by Claude AI (Anthropic) and ChatGPT (OpenAI) based on publicly available SEC EDGAR filings. It does not include stock price data and should not be considered financial advice. All fundamental data is sourced from SEC public domain filings. Always conduct your own research and consult with a qualified financial advisor before making investment decisions.
Data Source: SEC EDGAR | Analysis Date: Apr 14, 2026 | Data as of: 2025-12-31 | Powered by Claude AI