← Back to All US Stocks

Zymeworks Inc. (ZYME) Stock Fundamental Analysis & AI Rating 2026

ZYME Nasdaq Pharmaceutical Preparations DE CIK: 0001937653
Recently Updated • Analysis: Apr 20, 2026 • SEC Data: 2025-12-31
SELL
72% Conf
Pending
Analysis scheduled

📊 ZYME Key Takeaways

Revenue: $106.0M
Net Margin: -76.6%
Free Cash Flow: $-34.5M
Current Ratio: 5.88x
Debt/Equity: 0.00x
EPS: $-1.08
AI Rating: SELL with 72% confidence
Zymeworks Inc. (ZYME) receives a SELL rating with 72% confidence from our AI fundamental analysis based on SEC 10-K filings. With revenue of $106.0M, net profit margin of -76.6%, and return on equity (ROE) of -30.2%, Zymeworks Inc. demonstrates mixed fundamentals in the Healthcare sector. Below is our complete ZYME stock analysis for 2026.

Is Zymeworks Inc. (ZYME) a Good Investment?

Claude

Zymeworks exhibits strong revenue growth (+38.9% YoY) with improving loss trends (EPS +33.3% YoY), but remains deeply unprofitable with -87.3% operating margins and negative free cash flow (-$34.5M). While the strong balance sheet ($268.5M equity, 0.00x D/E) provides runway, the company lacks a demonstrated path to profitability with losses consuming nearly 77 cents per dollar of revenue.

Why Buy Zymeworks Inc. Stock? ZYME Key Strengths

Claude
  • + Revenue growth of 38.9% YoY demonstrates top-line momentum
  • + Improving loss profile with diluted EPS loss shrinking 33.3% YoY
  • + Fortress balance sheet with $268.5M equity, no long-term debt, and 5.88x current ratio

ZYME Stock Risks: Zymeworks Inc. Investment Risks

Claude
  • ! Operating losses of $92.5M against $106M revenue indicate severe unit economics
  • ! Negative operating cash flow (-$33M) and free cash flow (-$34.5M) create ~15-month cash runway at current burn
  • ! No gross margin data available; operating margin of -87.3% suggests R&D-heavy model without margin expansion evidence

Key Metrics to Watch

Claude
  • * Gross profit margin trend (critical missing data for pharma analysis)
  • * Operating cash flow inflection point to positive
  • * Revenue growth sustainability and cost structure rationalization
  • * Cash runway and timeline to break-even on operating basis

Zymeworks Inc. (ZYME) Financial Metrics & Key Ratios

Revenue
$106.0M
Net Income
$-81.1M
EPS (Diluted)
$-1.08
Free Cash Flow
$-34.5M
Total Assets
$346.5M
Cash Position
$41.2M

💡 AI Analyst Insight

Strong liquidity with a 5.88x current ratio provides a solid financial cushion.

ZYME Profit Margin, ROE & Profitability Analysis

Gross Margin N/A
Operating Margin -87.3%
Net Margin -76.6%
ROE -30.2%
ROA -23.4%
FCF Margin -32.6%

ZYME vs Healthcare Sector: How Zymeworks Inc. Compares

How Zymeworks Inc. compares to Healthcare sector averages

Net Margin
ZYME -76.6%
vs
Sector Avg 12.0%
ZYME Sector
ROE
ZYME -30.2%
vs
Sector Avg 15.0%
ZYME Sector
Current Ratio
ZYME 5.9x
vs
Sector Avg 2.0x
ZYME Sector
Debt/Equity
ZYME 0.0x
vs
Sector Avg 0.6x
ZYME Sector

Sector benchmarks are approximate industry averages. Actual sector performance may vary.

Is Zymeworks Inc. Stock Overvalued? ZYME Valuation Analysis 2026

Based on fundamental analysis, Zymeworks Inc. has mixed fundamental signals relative to the Healthcare sector in 2026.

Return on Equity
-30.2%
Sector avg: 15%
Net Profit Margin
-76.6%
Sector avg: 12%
Revenue Growth
N/A
Year-over-year
Debt/Equity
0.00x
Sector avg: 0.6x

Note: This is a fundamental analysis based on SEC filings. For P/E ratio, price targets, and market-based valuation, consult financial data providers. This is not investment advice.

Zymeworks Inc. Balance Sheet: ZYME Debt, Cash & Liquidity

Current Ratio
5.88x
Quick Ratio
5.88x
Debt/Equity
0.00x
Debt/Assets
22.5%
Interest Coverage
N/A
Long-term Debt
N/A

ZYME Revenue & Earnings Growth: 5-Year Financial Trend

ZYME 5-year financial data: Year 2022: Revenue $412.5M, Net Income -$180.6M, EPS $-3.58. Year 2023: Revenue $412.5M, Net Income -$211.8M, EPS $-4.61. Year 2024: Revenue $412.5M, Net Income $124.3M, EPS $1.90. Year 2025: Revenue $106.0M, Net Income -$118.7M, EPS $-1.72.
Revenue
Net Income
EPS (right axis)

5-Year Trend Summary: Zymeworks Inc.'s revenue has declined by 74% over the 5-year period, indicating business contraction. The most recent EPS of $-1.72 indicates the company is currently unprofitable.

ZYME Revenue Growth, EPS Growth & YoY Performance

Revenue Growth
N/A
Year-over-year
Net Income Growth
N/A
Year-over-year
EPS Growth
N/A
Earnings per share
FCF Margin
-32.6%
Free cash flow / Revenue

ZYME Quarterly Earnings & Performance

Quarterly financial performance data for Zymeworks Inc. including revenue, net income, and earnings per share.
Quarter Revenue Net Income EPS
Q3 2025 $16.0M $2.3M $-0.26
Q2 2025 $19.2M $2.3M $0.03
Q1 2025 $10.0M -$22.6M $-0.30
Q3 2024 $16.0M -$24.4M $-0.39
Q2 2024 $7.0M -$24.4M $-0.49
Q1 2024 $10.0M -$24.4M $-0.37
Q3 2023 $2.6M -$24.4M $-0.41
Q2 2023 $5.4M -$24.4M $-0.76

Data sourced from SEC EDGAR 10-Q quarterly filings. Figures may represent quarterly or cumulative values.

Zymeworks Inc. Dividends, Buybacks & Capital Allocation

Operating Cash Flow
-$33.0M
Cash generated from operations
Stock Buybacks
$41.7M
Shares repurchased (TTM)
Capital Expenditures
$1.5M
Investment in assets
Dividends
None
No dividend program

ZYME SEC Filings: Latest 10-K & 10-Q Analysis

Access official SEC EDGAR filings for Zymeworks Inc. (CIK: 0001937653)

📋 Recent SEC Filings

Date Form Document Action
Apr 10, 2026 4 xslF345X06/ownership.xml View →
Apr 10, 2026 4 xslF345X06/ownership.xml View →
Apr 7, 2026 4 xslF345X06/ownership.xml View →
Apr 1, 2026 8-K d142598d8k.htm View →
Mar 2, 2026 8-K d118476d8k.htm View →

Frequently Asked Questions about ZYME

What is the AI rating for ZYME?

Zymeworks Inc. (ZYME) has an AI rating of SELL with 72% confidence, based on fundamental analysis of SEC EDGAR filings.

What are ZYME's key strengths?

Claude: Revenue growth of 38.9% YoY demonstrates top-line momentum. Improving loss profile with diluted EPS loss shrinking 33.3% YoY.

What are the risks of investing in ZYME?

Claude: Operating losses of $92.5M against $106M revenue indicate severe unit economics. Negative operating cash flow (-$33M) and free cash flow (-$34.5M) create ~15-month cash runway at current burn.

What is ZYME's revenue and growth?

Zymeworks Inc. reported revenue of $106.0M.

Does ZYME pay dividends?

Zymeworks Inc. does not currently pay dividends.

Where can I find ZYME SEC filings?

Official SEC filings for Zymeworks Inc. (CIK: 0001937653) including 10-K, 10-Q, and 8-K reports are available on SEC EDGAR.

What is ZYME's EPS?

Zymeworks Inc. has a diluted EPS of $-1.08.

How is the AI analysis conducted?

Two independent AI systems — Claude (Anthropic) and ChatGPT (OpenAI) — analyze SEC EDGAR filings including 10-K annual reports and 10-Q quarterly reports. Each AI evaluates financial health, profitability ratios, balance sheet strength, and growth metrics. The combined rating reflects both perspectives for balanced insights.

Is ZYME a good stock to buy right now?

Based on our AI fundamental analysis in April 2026, Zymeworks Inc. has a SELL rating with 72% confidence. Review the strengths and risks sections above before making a decision. This is not investment advice.

Is ZYME stock overvalued or undervalued?

Valuation metrics for ZYME: ROE of -30.2% (sector avg: 15%), net margin of -76.6% (sector avg: 12%). Compare these metrics with sector averages to assess valuation.

Should I buy ZYME stock in 2026?

Our dual AI analysis gives Zymeworks Inc. a combined SELL rating for 2026. Revenue is data pending, with profitability at or below sector average. Always conduct your own research.

What is ZYME's free cash flow?

Zymeworks Inc.'s operating cash flow is $-33.0M, with capital expenditures of $1.5M. FCF margin is -32.6%.

How does ZYME compare to other Healthcare stocks?

Vs Healthcare sector averages: Net margin -76.6% (avg: 12%), ROE -30.2% (avg: 15%), current ratio 5.88 (avg: 2).

Top Rated Stocks
NSSC 92% MLI 92% MELI 92% MDXG 92% MANH 92% INVA 92% GGG 92% GCT 92% FTNT 92% FSLR 92%
Sector: All Healthcare Stocks →
Disclaimer: This analysis is generated by Claude AI (Anthropic) and ChatGPT (OpenAI) based on publicly available SEC EDGAR filings. It does not include stock price data and should not be considered financial advice. All fundamental data is sourced from SEC public domain filings. Always conduct your own research and consult with a qualified financial advisor before making investment decisions.
Data Source: SEC EDGAR | Analysis Date: Apr 20, 2026 | Data as of: 2025-12-31 | Powered by Claude AI