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Zentalis Pharmaceuticals, Inc. (ZNTL) Stock Fundamental Analysis & AI Rating 2026

ZNTL Nasdaq Pharmaceutical Preparations CIK: 0001725160
Recently Updated • Analysis: Apr 19, 2026 • SEC Data: 2025-12-31
STRONG SELL
88% Conf
Pending
Analysis scheduled

📊 ZNTL Key Takeaways

Revenue: $0.0
Net Margin: N/A
Free Cash Flow: $-125.2M
Current Ratio: 6.93x
Debt/Equity: 0.00x
EPS: $-1.91
AI Rating: STRONG SELL with 88% confidence
Zentalis Pharmaceuticals, Inc. (ZNTL) receives a STRONG SELL rating with 88% confidence from our AI fundamental analysis based on SEC 10-K filings. With revenue of $0, and return on equity (ROE) of -63.4%, Zentalis Pharmaceuticals, Inc. demonstrates mixed fundamentals in the Healthcare sector. Below is our complete ZNTL stock analysis for 2026.

Is Zentalis Pharmaceuticals, Inc. (ZNTL) a Good Investment?

Claude

Zentalis is a pre-revenue clinical-stage pharmaceutical company burning $125.2M annually with only $36M in cash, providing approximately 3.5 months of operational runway. The zero revenue, unsustainable cash burn relative to available liquidity, and dependence on successful clinical outcomes create an existential financial risk with high probability of near-term capital needs or insolvency.

Why Buy Zentalis Pharmaceuticals, Inc. Stock? ZNTL Key Strengths

Claude
  • + Strong equity position of $216.2M provides financial cushion and absorbs operational losses
  • + Zero debt eliminates debt servicing pressure and interest obligations
  • + Excellent current ratio of 6.93x indicates strong short-term asset liquidity position

ZNTL Stock Risks: Zentalis Pharmaceuticals, Inc. Investment Risks

Claude
  • ! Zero revenue with no approved commercial products; purely pre-revenue development stage
  • ! Critical cash runway of 3.5 months at current $125.2M annual burn rate against $36M available cash
  • ! Imminent capital requirements through equity raise (significant dilution) or debt financing
  • ! Complete dependence on clinical trial success and FDA regulatory approval for any revenue realization
  • ! Negative operating cash flow of $125.2M with no visible profitability pathway

Key Metrics to Watch

Claude
  • * Quarterly cash position and monthly burn rate trends for runway sustainability
  • * Clinical trial advancement milestones and regulatory approval timelines for pipeline candidates
  • * Capital raise announcements including dilution impact and funding adequacy

Zentalis Pharmaceuticals, Inc. (ZNTL) Financial Metrics & Key Ratios

Revenue
$0.0
Net Income
$-137.1M
EPS (Diluted)
$-1.91
Free Cash Flow
$-125.2M
Total Assets
$289.0M
Cash Position
$36.0M

💡 AI Analyst Insight

Strong liquidity with a 6.93x current ratio provides a solid financial cushion.

ZNTL Profit Margin, ROE & Profitability Analysis

Gross Margin N/A
Operating Margin N/A
Net Margin N/A
ROE -63.4%
ROA -47.4%
FCF Margin N/A

ZNTL vs Healthcare Sector: How Zentalis Pharmaceuticals, Inc. Compares

How Zentalis Pharmaceuticals, Inc. compares to Healthcare sector averages

Net Margin
ZNTL 0.0%
vs
Sector Avg 12.0%
ZNTL Sector
ROE
ZNTL -63.4%
vs
Sector Avg 15.0%
ZNTL Sector
Current Ratio
ZNTL 6.9x
vs
Sector Avg 2.0x
ZNTL Sector
Debt/Equity
ZNTL 0.0x
vs
Sector Avg 0.6x
ZNTL Sector

Sector benchmarks are approximate industry averages. Actual sector performance may vary.

Is Zentalis Pharmaceuticals, Inc. Stock Overvalued? ZNTL Valuation Analysis 2026

Based on fundamental analysis, Zentalis Pharmaceuticals, Inc. has mixed fundamental signals relative to the Healthcare sector in 2026.

Return on Equity
-63.4%
Sector avg: 15%
Net Profit Margin
N/A
Sector avg: 12%
Revenue Growth
N/A
Year-over-year
Debt/Equity
0.00x
Sector avg: 0.6x

Note: This is a fundamental analysis based on SEC filings. For P/E ratio, price targets, and market-based valuation, consult financial data providers. This is not investment advice.

Zentalis Pharmaceuticals, Inc. Balance Sheet: ZNTL Debt, Cash & Liquidity

Current Ratio
6.93x
Quick Ratio
6.93x
Debt/Equity
0.00x
Debt/Assets
25.2%
Interest Coverage
N/A
Long-term Debt
N/A

ZNTL Revenue & Earnings Growth: 5-Year Financial Trend

ZNTL 5-year financial data: Year 2024: Revenue $67.4M, Net Income -$236.8M, EPS $-4.48. Year 2025: Revenue $67.4M, Net Income -$292.2M, EPS $-4.47.
Revenue
Net Income
EPS (right axis)

5-Year Trend Summary: Zentalis Pharmaceuticals, Inc.'s revenue has remained relatively flat over the 5-year period, with a 0% decline. The most recent EPS of $-4.47 indicates the company is currently unprofitable.

ZNTL Revenue Growth, EPS Growth & YoY Performance

Revenue Growth
N/A
Year-over-year
Net Income Growth
N/A
Year-over-year
EPS Growth
N/A
Earnings per share
FCF Margin
N/A
Free cash flow / Revenue

ZNTL Quarterly Earnings & Performance

Quarterly financial performance data for Zentalis Pharmaceuticals, Inc. including revenue, net income, and earnings per share.
Quarter Revenue Net Income EPS
Q3 2025 N/A -$26.7M $-0.37
Q2 2025 N/A -$26.9M $-0.37
Q1 2025 N/A $10.1M $0.14
Q3 2024 N/A -$40.2M $-0.56
Q2 2024 N/A -$78.2M $-1.10
Q1 2024 N/A $10.1M $0.14

Data sourced from SEC EDGAR 10-Q quarterly filings. Figures may represent quarterly or cumulative values.

Zentalis Pharmaceuticals, Inc. Dividends, Buybacks & Capital Allocation

Operating Cash Flow
-$125.2M
Cash generated from operations
Stock Buybacks
$10.0M
Shares repurchased (TTM)
Dividends
None
No dividend program

ZNTL SEC Filings: Latest 10-K & 10-Q Analysis

Access official SEC EDGAR filings for Zentalis Pharmaceuticals, Inc. (CIK: 0001725160)

📋 Recent SEC Filings

Date Form Document Action
Apr 17, 2026 8-K zntl-20260417.htm View →
Apr 9, 2026 8-K zntl-20260409.htm View →
Mar 26, 2026 10-K zntl-20251231.htm View →
Mar 26, 2026 8-K zntl-20260326.htm View →
Feb 10, 2026 4 xslF345X05/wk-form4_1770775846.xml View →

Frequently Asked Questions about ZNTL

What is the AI rating for ZNTL?

Zentalis Pharmaceuticals, Inc. (ZNTL) has an AI rating of STRONG SELL with 88% confidence, based on fundamental analysis of SEC EDGAR filings.

What are ZNTL's key strengths?

Claude: Strong equity position of $216.2M provides financial cushion and absorbs operational losses. Zero debt eliminates debt servicing pressure and interest obligations.

What are the risks of investing in ZNTL?

Claude: Zero revenue with no approved commercial products; purely pre-revenue development stage. Critical cash runway of 3.5 months at current $125.2M annual burn rate against $36M available cash.

What is ZNTL's revenue and growth?

Zentalis Pharmaceuticals, Inc. reported revenue of $0.0.

Does ZNTL pay dividends?

Zentalis Pharmaceuticals, Inc. does not currently pay dividends.

Where can I find ZNTL SEC filings?

Official SEC filings for Zentalis Pharmaceuticals, Inc. (CIK: 0001725160) including 10-K, 10-Q, and 8-K reports are available on SEC EDGAR.

What is ZNTL's EPS?

Zentalis Pharmaceuticals, Inc. has a diluted EPS of $-1.91.

How is the AI analysis conducted?

Two independent AI systems — Claude (Anthropic) and ChatGPT (OpenAI) — analyze SEC EDGAR filings including 10-K annual reports and 10-Q quarterly reports. Each AI evaluates financial health, profitability ratios, balance sheet strength, and growth metrics. The combined rating reflects both perspectives for balanced insights.

Is ZNTL a good stock to buy right now?

Based on our AI fundamental analysis in April 2026, Zentalis Pharmaceuticals, Inc. has a STRONG SELL rating with 88% confidence. Review the strengths and risks sections above before making a decision. This is not investment advice.

Is ZNTL stock overvalued or undervalued?

Valuation metrics for ZNTL: ROE of -63.4% (sector avg: 15%), net margin of N/A (sector avg: 12%). Compare these metrics with sector averages to assess valuation.

Should I buy ZNTL stock in 2026?

Our dual AI analysis gives Zentalis Pharmaceuticals, Inc. a combined STRONG SELL rating for 2026. Revenue is data pending, with profitability at or below sector average. Always conduct your own research.

What is ZNTL's free cash flow?

Zentalis Pharmaceuticals, Inc.'s operating cash flow is $-125.2M, with capital expenditures of $0.0.

How does ZNTL compare to other Healthcare stocks?

Vs Healthcare sector averages: Net margin N/A (avg: 12%), ROE -63.4% (avg: 15%), current ratio 6.93 (avg: 2).

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Disclaimer: This analysis is generated by Claude AI (Anthropic) and ChatGPT (OpenAI) based on publicly available SEC EDGAR filings. It does not include stock price data and should not be considered financial advice. All fundamental data is sourced from SEC public domain filings. Always conduct your own research and consult with a qualified financial advisor before making investment decisions.
Data Source: SEC EDGAR | Analysis Date: Apr 19, 2026 | Data as of: 2025-12-31 | Powered by Claude AI