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Zentalis Pharmaceuticals, Inc. (ZNTL) Fundamental Analysis & AI Grade 2026

ZNTL Nasdaq Pharmaceutical Preparations CIK: 0001725160
Updated This Month • Analysis: May 15, 2026 • SEC Data: 2026-03-31
Combined AI Grade
C
75% Confidence
N/A
C
75% Conf
Pending
Analysis scheduled

📊 ZNTL Key Takeaways

Revenue: $0.0
Net Margin: N/A
Free Cash Flow: $-33.0M
Current Ratio: 6.19x
Debt/Equity: 0.00x
EPS: $-0.50
AI Grade: C with 75% confidence
Zentalis Pharmaceuticals, Inc. (ZNTL) receives a C fundamental grade with 75% confidence from our AI analysis based on SEC 10-K filings. With revenue of $0, and return on equity (ROE) of -19.4%, Zentalis Pharmaceuticals, Inc. demonstrates mixed fundamentals in the Healthcare sector. Below is our complete ZNTL stock analysis for 2026.

Is Zentalis Pharmaceuticals, Inc. (ZNTL) a Good Investment?

Claude

Zentalis is a pre-revenue, cash-burning pharmaceutical development company with zero revenue and $33M annual operating cash burn against only $31.9M in cash reserves, implying approximately 11-12 months of runway. While the balance sheet is fortress-like with no debt and strong liquidity, the fundamental absence of revenue, persistent losses, and limited financial runway present material solvency risk without successful clinical outcomes or additional financing.

Zentalis Pharmaceuticals, Inc. Key Strengths (ZNTL)

Claude
  • + Zero long-term debt and no financial leverage
  • + Strong balance sheet with $182.7M stockholders equity and 6.19x current ratio
  • + Improving loss trajectory with net income losses declining 17.4% year-over-year
  • + Minimal capital intensity with only $34K capex, preserving cash for operations

ZNTL Stock Risks: Zentalis Pharmaceuticals, Inc. Investment Risks

Claude
  • ! Zero revenue with no approved commercial products generating sales
  • ! Operating cash burn of $33M annually against only $31.9M cash, creating critical runway pressure
  • ! Pre-revenue development-stage model dependent on unproven clinical outcomes and regulatory approval
  • ! Limited financial flexibility if development timelines extend or clinical trials fail
  • ! No insider buying activity in past 90 days suggests internal confidence concerns

Key Metrics to Watch

Claude
  • * Cash burn rate trends and cash runway depletion
  • * Clinical trial progression and regulatory milestone achievements
  • * Quarterly cash position changes and capital raise activity
  • * Operating expense management and burn rate improvement

Zentalis Pharmaceuticals, Inc. (ZNTL) Financial Metrics & Key Ratios

Revenue
$0.0
Net Income
$-35.4M
EPS (Diluted)
$-0.50
Free Cash Flow
$-33.0M
Total Assets
$253.1M
Cash Position
$31.9M

💡 AI Analyst Insight

Strong liquidity with a 6.19x current ratio provides a solid financial cushion.

ZNTL Profit Margin, ROE & Profitability Analysis

Gross Margin N/A
Operating Margin N/A
Net Margin N/A
ROE -19.4%
ROA -14.0%
FCF Margin N/A

ZNTL vs Healthcare Sector: How Zentalis Pharmaceuticals, Inc. Compares

How Zentalis Pharmaceuticals, Inc. compares to Healthcare sector averages

Net Margin
ZNTL 0.0%
vs
Sector Avg 12.0%
ZNTL Sector
ROE
ZNTL -19.4%
vs
Sector Avg 15.0%
ZNTL Sector
Current Ratio
ZNTL 6.2x
vs
Sector Avg 2.0x
ZNTL Sector
Debt/Equity
ZNTL 0.0x
vs
Sector Avg 0.6x
ZNTL Sector

Sector benchmarks are approximate industry averages. Actual sector performance may vary.

Is Zentalis Pharmaceuticals, Inc. Stock Overvalued? ZNTL Valuation Analysis 2026

Based on fundamental analysis, Zentalis Pharmaceuticals, Inc. has mixed fundamental signals relative to the Healthcare sector in 2026.

Return on Equity
-19.4%
Sector avg: 15%
Net Profit Margin
N/A
Sector avg: 12%
Revenue Growth
N/A
Year-over-year
Debt/Equity
0.00x
Sector avg: 0.6x

Note: This is a fundamental analysis based on SEC filings. For P/E ratio, price targets, and market-based valuation, consult financial data providers. This is not investment advice.

Zentalis Pharmaceuticals, Inc. Balance Sheet: ZNTL Debt, Cash & Liquidity

Current Ratio
6.19x
Quick Ratio
6.19x
Debt/Equity
0.00x
Debt/Assets
27.8%
Interest Coverage
N/A
Long-term Debt
N/A

ZNTL Revenue & Earnings Growth: 5-Year Financial Trend

ZNTL 5-year financial data: Year 2024: Revenue $67.4M, Net Income -$236.8M, EPS $-4.48. Year 2025: Revenue $67.4M, Net Income -$292.2M, EPS $-4.47.
Revenue
Net Income
EPS (right axis)

5-Year Trend Summary: Zentalis Pharmaceuticals, Inc.'s revenue has remained relatively flat over the 5-year period, with a 0% decline. The most recent EPS of $-4.47 indicates the company is currently unprofitable.

ZNTL Revenue Growth, EPS Growth & YoY Performance

Revenue Growth
N/A
Year-over-year
Net Income Growth
N/A
Year-over-year
EPS Growth
N/A
Earnings per share
FCF Margin
N/A
Free cash flow / Revenue

ZNTL Quarterly Earnings & Performance

Quarterly financial performance data for Zentalis Pharmaceuticals, Inc. including revenue, net income, and earnings per share.
Quarter Revenue Net Income EPS
Q3 2025 N/A -$26.7M $-0.37
Q2 2025 N/A -$26.9M $-0.37
Q1 2025 N/A $10.1M $0.14
Q3 2024 N/A -$40.2M $-0.56
Q2 2024 N/A -$78.2M $-1.10
Q1 2024 N/A $10.1M $0.14

Data sourced from SEC EDGAR 10-Q quarterly filings. Figures may represent quarterly or cumulative values.

Zentalis Pharmaceuticals, Inc. Dividends, Buybacks & Capital Allocation

Operating Cash Flow
-$33.0M
Cash generated from operations
Stock Buybacks
$10.0M
Shares repurchased (TTM)
Capital Expenditures
$34.0K
Investment in assets
Dividends
None
No dividend program

ZNTL SEC Filings: Latest 10-K & 10-Q Analysis

Access official SEC EDGAR filings for Zentalis Pharmaceuticals, Inc. (CIK: 0001725160)

📋 Recent SEC Filings

Date Form Document Action
May 27, 2026 4 xslF345X06/wk-form4_1779912686.xml View →
May 27, 2026 8-K zntl-20260522.htm View →
May 21, 2026 8-K zntl-20260521.htm View →
May 12, 2026 10-Q zntl-20260331.htm View →
May 12, 2026 8-K zntl-20260512.htm View →

Frequently Asked Questions about ZNTL

What is the AI rating for ZNTL?

Zentalis Pharmaceuticals, Inc. (ZNTL) has an AI grade of C with 75% confidence, based on fundamental analysis of SEC EDGAR filings.

What are ZNTL's key strengths?

Claude: Zero long-term debt and no financial leverage. Strong balance sheet with $182.7M stockholders equity and 6.19x current ratio.

What are the risks of investing in ZNTL?

Claude: Zero revenue with no approved commercial products generating sales. Operating cash burn of $33M annually against only $31.9M cash, creating critical runway pressure.

What is ZNTL's revenue and growth?

Zentalis Pharmaceuticals, Inc. reported revenue of $0.0.

Does ZNTL pay dividends?

Zentalis Pharmaceuticals, Inc. does not currently pay dividends.

Where can I find ZNTL SEC filings?

Official SEC filings for Zentalis Pharmaceuticals, Inc. (CIK: 0001725160) including 10-K, 10-Q, and 8-K reports are available on SEC EDGAR.

What is ZNTL's EPS?

Zentalis Pharmaceuticals, Inc. has a diluted EPS of $-0.50.

How is the AI analysis conducted?

Two independent AI systems — Claude (Anthropic) and ChatGPT (OpenAI) — analyze SEC EDGAR filings including 10-K annual reports and 10-Q quarterly reports. Each AI evaluates financial health, profitability ratios, balance sheet strength, and growth metrics. The combined grade reflects both perspectives for balanced insights.

What is ZNTL's fundamental grade?

Based on our AI fundamental analysis in June 2026, Zentalis Pharmaceuticals, Inc. has a C grade with 75% confidence. Review the strengths and risks sections above for full context. This is not investment advice.

Is ZNTL stock overvalued or undervalued?

Valuation metrics for ZNTL: ROE of -19.4% (sector avg: 15%), net margin of N/A (sector avg: 12%). Compare these metrics with sector averages to assess valuation.

What is ZNTL's AI grade for 2026?

Our dual AI analysis gives Zentalis Pharmaceuticals, Inc. a combined C grade for 2026. Revenue is data pending, with profitability at or below sector average. Always conduct your own research.

What is ZNTL's free cash flow?

Zentalis Pharmaceuticals, Inc.'s operating cash flow is $-33.0M, with capital expenditures of $34.0K.

How does ZNTL compare to other Healthcare stocks?

Vs Healthcare sector averages: Net margin N/A (avg: 12%), ROE -19.4% (avg: 15%), current ratio 6.19 (avg: 2).

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Disclaimer: This analysis is generated by Claude AI (Anthropic) and ChatGPT (OpenAI) based on publicly available SEC EDGAR filings. It does not include stock price data and should not be considered financial advice. All fundamental data is sourced from SEC public domain filings. Always conduct your own research and consult with a qualified financial advisor before making investment decisions.
Data Source: SEC EDGAR | Analysis Date: May 15, 2026 | Data as of: 2026-03-31 | Powered by Claude AI