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Xeris Biopharma Holdings, Inc. (XERS) Fundamental Analysis & AI Grade 2026

XERS Nasdaq Pharmaceutical Preparations CIK: 0001867096
Updated This Month • Analysis: May 9, 2026 • SEC Data: 2026-03-31
Combined AI Grade
B
65% Confidence
N/A
B
65% Conf
Pending
Analysis scheduled

📊 XERS Key Takeaways

Revenue: $83.1M
Net Margin: 2.7%
Free Cash Flow: $8.8M
Current Ratio: 2.12x
Debt/Equity: 17.00x
EPS: $0.01
AI Grade: B with 65% confidence
Xeris Biopharma Holdings, Inc. (XERS) receives a B fundamental grade with 65% confidence from our AI analysis based on SEC 10-K filings. With revenue of $83.1M, net profit margin of 2.7%, and return on equity (ROE) of 17.2%, Xeris Biopharma Holdings, Inc. demonstrates mixed fundamentals in the Healthcare sector. Below is our complete XERS stock analysis for 2026.

Is Xeris Biopharma Holdings, Inc. (XERS) a Good Investment?

Claude

Xeris demonstrates strong operational momentum with 43.7% revenue growth and exceptional 101% net income improvement, supported by positive free cash flow of $8.8M and a solid $111.8M cash position. However, severe balance sheet leverage (17.0x debt-to-equity) and critically low interest coverage (1.1x) create significant financial risk that must be addressed through debt reduction or substantial margin expansion before a positive recommendation is warranted.

Xeris Biopharma Holdings, Inc. Key Strengths (XERS)

Claude
  • + Strong revenue growth of 43.7% YoY demonstrating market demand and product traction
  • + Exceptional net income growth of 101% YoY showing operational leverage improving
  • + Robust cash position of $111.8M providing financial flexibility and runway
  • + Positive free cash flow generation of $8.8M with 10.6% FCF margin
  • + Healthy liquidity ratios (Current 2.12x, Quick 1.50x) supporting short-term obligations

XERS Stock Risks: Xeris Biopharma Holdings, Inc. Investment Risks

Claude
  • ! Dangerously high leverage with 17.0x debt-to-equity ratio concentrated in $221.2M long-term debt
  • ! Critically low interest coverage ratio of 1.1x providing minimal cushion for debt service disruption
  • ! Extremely thin net profit margin of 2.7% limiting operational error tolerance
  • ! Severely undercapitalized equity base ($13.0M) relative to $379.0M liabilities creates solvency concerns
  • ! Pharmaceutical sector regulatory, patent, and competitive risks could impair revenue sustainability

Key Metrics to Watch

Claude
  • * Interest coverage ratio - must improve above 2.0x for adequate debt service capacity
  • * Debt reduction and debt-to-equity ratio - trajectory toward <5.0x is critical
  • * Net profit margin expansion - pathway to sustain growth without additional leverage
  • * Operating cash flow consistency - essential for meeting interest obligations and refinancing

Xeris Biopharma Holdings, Inc. (XERS) Financial Metrics & Key Ratios

Revenue
$83.1M
Net Income
$2.2M
EPS (Diluted)
$0.01
Free Cash Flow
$8.8M
Total Assets
$392.0M
Cash Position
$111.8M

💡 AI Analyst Insight

Strong liquidity with a 2.12x current ratio provides a solid financial cushion.

XERS Profit Margin, ROE & Profitability Analysis

Gross Margin 23.7%
Operating Margin 9.5%
Net Margin 2.7%
ROE 17.2%
ROA 0.6%
FCF Margin 10.6%

XERS vs Healthcare Sector: How Xeris Biopharma Holdings, Inc. Compares

How Xeris Biopharma Holdings, Inc. compares to Healthcare sector averages

Net Margin
XERS 2.7%
vs
Sector Avg 12.0%
XERS Sector
ROE
XERS 17.2%
vs
Sector Avg 15.0%
XERS Sector
Current Ratio
XERS 2.1x
vs
Sector Avg 2.0x
XERS Sector
Debt/Equity
XERS 17.0x
vs
Sector Avg 0.6x
XERS Sector

Sector benchmarks are approximate industry averages. Actual sector performance may vary.

Is Xeris Biopharma Holdings, Inc. Stock Overvalued? XERS Valuation Analysis 2026

Based on fundamental analysis, Xeris Biopharma Holdings, Inc. shows some fundamental concerns relative to the Healthcare sector in 2026.

Return on Equity
17.2%
Sector avg: 15%
Net Profit Margin
2.7%
Sector avg: 12%
Revenue Growth
N/A
Year-over-year
Debt/Equity
17.00x
Sector avg: 0.6x

Note: This is a fundamental analysis based on SEC filings. For P/E ratio, price targets, and market-based valuation, consult financial data providers. This is not investment advice.

Xeris Biopharma Holdings, Inc. Balance Sheet: XERS Debt, Cash & Liquidity

Current Ratio
2.12x
Quick Ratio
1.50x
Debt/Equity
17.00x
Debt/Assets
96.7%
Interest Coverage
1.13x
Long-term Debt
$221.2M

XERS Revenue & Earnings Growth: 5-Year Financial Trend

XERS 5-year financial data: Year 2021: Revenue $49.3M, Net Income -$91.1M, EPS N/A. Year 2022: Revenue $110.2M, Net Income -$122.7M, EPS $-1.55. Year 2023: Revenue $163.9M, Net Income -$122.7M, EPS $-1.55. Year 2024: Revenue $203.1M, Net Income -$94.7M, EPS $-0.70. Year 2025: Revenue $291.8M, Net Income -$62.3M, EPS $-0.45.
Revenue
Net Income
EPS (right axis)

5-Year Trend Summary: Xeris Biopharma Holdings, Inc.'s revenue has grown significantly by 492% over the 5-year period, indicating strong business expansion. The most recent EPS of $-0.45 indicates the company is currently unprofitable.

XERS Revenue Growth, EPS Growth & YoY Performance

Revenue Growth
N/A
Year-over-year
Net Income Growth
N/A
Year-over-year
EPS Growth
N/A
Earnings per share
FCF Margin
10.6%
Free cash flow / Revenue

XERS Quarterly Earnings & Performance

Quarterly financial performance data for Xeris Biopharma Holdings, Inc. including revenue, net income, and earnings per share.
Quarter Revenue Net Income EPS
Q1 2026 $60.1M $2.2M $0.01
Q3 2025 $54.3M $621.0K $0.00
Q2 2025 $48.1M -$1.9M $-0.01
Q1 2025 $40.6M -$9.2M $-0.06
Q3 2024 $48.3M -$12.2M $-0.09
Q2 2024 $38.0M -$15.0M $-0.10
Q3 2023 $29.7M -$12.2M $-0.09
Q3 2022 $11.1M -$18.4M $-0.16

Data sourced from SEC EDGAR 10-Q quarterly filings. Figures may represent quarterly or cumulative values.

Xeris Biopharma Holdings, Inc. Dividends, Buybacks & Capital Allocation

Operating Cash Flow
$9.9M
Cash generated from operations
Capital Expenditures
$1.1M
Investment in assets
Dividends
None
No dividend program

XERS SEC Filings: Latest 10-K & 10-Q Analysis

Access official SEC EDGAR filings for Xeris Biopharma Holdings, Inc. (CIK: 0001867096)

📋 Recent SEC Filings

Date Form Document Action
Jun 2, 2026 4 xslF345X06/wk-form4_1780437901.xml View →
May 7, 2026 10-Q xers-20260331.htm View →
May 7, 2026 8-K xers-20260507.htm View →
May 1, 2026 4 xslF345X06/wk-form4_1777672230.xml View →
Apr 23, 2026 DEF 14A xers-20260423.htm View →

Frequently Asked Questions about XERS

What is the AI rating for XERS?

Xeris Biopharma Holdings, Inc. (XERS) has an AI grade of B with 65% confidence, based on fundamental analysis of SEC EDGAR filings.

What are XERS's key strengths?

Claude: Strong revenue growth of 43.7% YoY demonstrating market demand and product traction. Exceptional net income growth of 101% YoY showing operational leverage improving.

What are the risks of investing in XERS?

Claude: Dangerously high leverage with 17.0x debt-to-equity ratio concentrated in $221.2M long-term debt. Critically low interest coverage ratio of 1.1x providing minimal cushion for debt service disruption.

What is XERS's revenue and growth?

Xeris Biopharma Holdings, Inc. reported revenue of $83.1M.

Does XERS pay dividends?

Xeris Biopharma Holdings, Inc. does not currently pay dividends.

Where can I find XERS SEC filings?

Official SEC filings for Xeris Biopharma Holdings, Inc. (CIK: 0001867096) including 10-K, 10-Q, and 8-K reports are available on SEC EDGAR.

What is XERS's EPS?

Xeris Biopharma Holdings, Inc. has a diluted EPS of $0.01.

How is the AI analysis conducted?

Two independent AI systems — Claude (Anthropic) and ChatGPT (OpenAI) — analyze SEC EDGAR filings including 10-K annual reports and 10-Q quarterly reports. Each AI evaluates financial health, profitability ratios, balance sheet strength, and growth metrics. The combined grade reflects both perspectives for balanced insights.

What is XERS's fundamental grade?

Based on our AI fundamental analysis in June 2026, Xeris Biopharma Holdings, Inc. has a B grade with 65% confidence. Review the strengths and risks sections above for full context. This is not investment advice.

Is XERS stock overvalued or undervalued?

Valuation metrics for XERS: ROE of 17.2% (sector avg: 15%), net margin of 2.7% (sector avg: 12%). Higher ROE suggests strong returns relative to peers.

What is XERS's AI grade for 2026?

Our dual AI analysis gives Xeris Biopharma Holdings, Inc. a combined B grade for 2026. Revenue is data pending, with profitability at or below sector average. Always conduct your own research.

What is XERS's free cash flow?

Xeris Biopharma Holdings, Inc.'s operating cash flow is $9.9M, with capital expenditures of $1.1M. FCF margin is 10.6%.

How does XERS compare to other Healthcare stocks?

Vs Healthcare sector averages: Net margin 2.7% (avg: 12%), ROE 17.2% (avg: 15%), current ratio 2.12 (avg: 2).

Is Xeris Biopharma Holdings, Inc. carrying too much debt?

XERS has a debt-to-equity ratio of 17.00x, which is above the Healthcare sector average of 0.6x. However, the current ratio of 2.12 suggests adequate short-term liquidity.

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Disclaimer: This analysis is generated by Claude AI (Anthropic) and ChatGPT (OpenAI) based on publicly available SEC EDGAR filings. It does not include stock price data and should not be considered financial advice. All fundamental data is sourced from SEC public domain filings. Always conduct your own research and consult with a qualified financial advisor before making investment decisions.
Data Source: SEC EDGAR | Analysis Date: May 9, 2026 | Data as of: 2026-03-31 | Powered by Claude AI