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VYNE Therapeutics Inc. (VYNE) Stock Fundamental Analysis & AI Rating 2026

VYNE Nasdaq Pharmaceutical Preparations DE CIK: 0001566044
Recently Updated • Analysis: Apr 18, 2026 • SEC Data: 2025-12-31
STRONG SELL
92% Conf
Pending
Analysis scheduled

📊 VYNE Key Takeaways

Revenue: $570.0K
Net Margin: -4,646.1%
Free Cash Flow: $-33.1M
Current Ratio: 12.53x
Debt/Equity: 0.00x
EPS: $-0.62
AI Rating: STRONG SELL with 92% confidence
VYNE Therapeutics Inc. (VYNE) receives a STRONG SELL rating with 92% confidence from our AI fundamental analysis based on SEC 10-K filings. With revenue of $570.0K, net profit margin of -4,646.1%, and return on equity (ROE) of -95.4%, VYNE Therapeutics Inc. demonstrates mixed fundamentals in the Healthcare sector. Below is our complete VYNE stock analysis for 2026.

Is VYNE Therapeutics Inc. (VYNE) a Good Investment?

Claude

VYNE faces critical financial distress with a sub-one-year cash runway ($24M cash versus $33.1M annual burn rate) despite minimal revenue generation ($570K). While the company has zero debt and improving loss metrics YoY, the combination of unsustainable operating cash burn and negligible revenue indicates urgent capital needs or potential insolvency risk without significant business inflection.

Why Buy VYNE Therapeutics Inc. Stock? VYNE Key Strengths

Claude
  • + Zero long-term debt and minimal liabilities ($2.4M) provides flexibility
  • + Revenue growth of +13.8% YoY shows some commercialization traction
  • + Net loss improved +33.5% YoY indicating cost management efforts
  • + Strong liquidity position ($24M cash, 12.53x current ratio)

VYNE Stock Risks: VYNE Therapeutics Inc. Investment Risks

Claude
  • ! Critical cash runway of approximately 9 months at current $33.1M annual burn rate
  • ! Minimal revenue generation ($570K) despite pharmaceutical sector positioning suggests product/market fit challenges
  • ! Massive operating cash burn (-$33.1M) exceeds revenue by 58x, indicating unsustainable business model
  • ! Imminent capital raise required; significant equity dilution likely if needed before cash depletion
  • ! No interest coverage and negative operating margins of -5219% indicate operational losses across all segments

Key Metrics to Watch

Claude
  • * Cash burn rate trajectory and quarterly runway remaining
  • * Revenue growth acceleration and path to breakeven operations
  • * Capital raise announcements and dilution impact
  • * Operating expense trends and cost structure optimization
  • * Product commercialization milestones and market adoption

VYNE Therapeutics Inc. (VYNE) Financial Metrics & Key Ratios

Revenue
$570.0K
Net Income
$-26.5M
EPS (Diluted)
$-0.62
Free Cash Flow
$-33.1M
Total Assets
$30.2M
Cash Position
$24.0M

💡 AI Analyst Insight

Strong liquidity with a 12.53x current ratio provides a solid financial cushion.

VYNE Profit Margin, ROE & Profitability Analysis

Gross Margin N/A
Operating Margin -5,219.1%
Net Margin -4,646.1%
ROE -95.4%
ROA -87.8%
FCF Margin -5,811.2%

VYNE vs Healthcare Sector: How VYNE Therapeutics Inc. Compares

How VYNE Therapeutics Inc. compares to Healthcare sector averages

Net Margin
VYNE -4,646.1%
vs
Sector Avg 12.0%
VYNE Sector
ROE
VYNE -95.4%
vs
Sector Avg 15.0%
VYNE Sector
Current Ratio
VYNE 12.5x
vs
Sector Avg 2.0x
VYNE Sector
Debt/Equity
VYNE 0.0x
vs
Sector Avg 0.6x
VYNE Sector

Sector benchmarks are approximate industry averages. Actual sector performance may vary.

Is VYNE Therapeutics Inc. Stock Overvalued? VYNE Valuation Analysis 2026

Based on fundamental analysis, VYNE Therapeutics Inc. has mixed fundamental signals relative to the Healthcare sector in 2026.

Return on Equity
-95.4%
Sector avg: 15%
Net Profit Margin
-4,646.1%
Sector avg: 12%
Revenue Growth
N/A
Year-over-year
Debt/Equity
0.00x
Sector avg: 0.6x

Note: This is a fundamental analysis based on SEC filings. For P/E ratio, price targets, and market-based valuation, consult financial data providers. This is not investment advice.

VYNE Therapeutics Inc. Balance Sheet: VYNE Debt, Cash & Liquidity

Current Ratio
12.53x
Quick Ratio
12.53x
Debt/Equity
0.00x
Debt/Assets
7.9%
Interest Coverage
N/A
Long-term Debt
$0.0

VYNE Revenue & Earnings Growth: 5-Year Financial Trend

VYNE 5-year financial data: Year 2021: Revenue $21.0M, Net Income -$255.6M, EPS $7.88. Year 2022: Revenue $931.0K, Net Income -$73.3M, EPS $-25.64. Year 2023: Revenue $477.0K, Net Income -$23.2M, EPS $-7.28. Year 2024: Revenue $501.0K, Net Income -$28.5M, EPS $-2.78. Year 2025: Revenue $570.0K, Net Income -$39.8M, EPS $-0.93.
Revenue
Net Income
EPS (right axis)

5-Year Trend Summary: VYNE Therapeutics Inc.'s revenue has declined by 97% over the 5-year period, indicating business contraction. The most recent EPS of $-0.93 indicates the company is currently unprofitable.

VYNE Revenue Growth, EPS Growth & YoY Performance

Revenue Growth
N/A
Year-over-year
Net Income Growth
N/A
Year-over-year
EPS Growth
N/A
Earnings per share
FCF Margin
-5,811.2%
Free cash flow / Revenue

VYNE Quarterly Earnings & Performance

Quarterly financial performance data for VYNE Therapeutics Inc. including revenue, net income, and earnings per share.
Quarter Revenue Net Income EPS
Q2 2025 $69.0K -$5.8M $-0.13
Q1 2025 $98.0K -$6.2M $-0.15
Q3 2024 $114.0K -$6.6M $-0.29
Q2 2024 $135.0K -$9.4M $-0.22
Q1 2024 $98.0K -$5.6M $-0.15
Q3 2023 $114.0K -$6.6M $-2.01
Q2 2023 $126.0K -$3.8M $-1.21
Q1 2023 $99.0K $4.7M $1.51

Data sourced from SEC EDGAR 10-Q quarterly filings. Figures may represent quarterly or cumulative values.

VYNE Therapeutics Inc. Dividends, Buybacks & Capital Allocation

Operating Cash Flow
-$33.1M
Cash generated from operations
Dividends Paid
$16.5M
Returned to shareholders

VYNE SEC Filings: Latest 10-K & 10-Q Analysis

Access official SEC EDGAR filings for VYNE Therapeutics Inc. (CIK: 0001566044)

📋 Recent SEC Filings

Date Form Document Action
Apr 2, 2026 4 xslF345X06/form4-04022026_040408.xml View →
Apr 2, 2026 4 xslF345X06/form4-04022026_040407.xml View →
Apr 2, 2026 4 xslF345X06/form4-04022026_040405.xml View →
Apr 2, 2026 4 xslF345X06/form4-04022026_040403.xml View →
Mar 11, 2026 8-K tm268461d1_8k.htm View →

Frequently Asked Questions about VYNE

What is the AI rating for VYNE?

VYNE Therapeutics Inc. (VYNE) has an AI rating of STRONG SELL with 92% confidence, based on fundamental analysis of SEC EDGAR filings.

What are VYNE's key strengths?

Claude: Zero long-term debt and minimal liabilities ($2.4M) provides flexibility. Revenue growth of +13.8% YoY shows some commercialization traction.

What are the risks of investing in VYNE?

Claude: Critical cash runway of approximately 9 months at current $33.1M annual burn rate. Minimal revenue generation ($570K) despite pharmaceutical sector positioning suggests product/market fit challenges.

What is VYNE's revenue and growth?

VYNE Therapeutics Inc. reported revenue of $570.0K.

Does VYNE pay dividends?

VYNE Therapeutics Inc. pays dividends, with $16.5M distributed to shareholders in the trailing twelve months.

Where can I find VYNE SEC filings?

Official SEC filings for VYNE Therapeutics Inc. (CIK: 0001566044) including 10-K, 10-Q, and 8-K reports are available on SEC EDGAR.

What is VYNE's EPS?

VYNE Therapeutics Inc. has a diluted EPS of $-0.62.

How is the AI analysis conducted?

Two independent AI systems — Claude (Anthropic) and ChatGPT (OpenAI) — analyze SEC EDGAR filings including 10-K annual reports and 10-Q quarterly reports. Each AI evaluates financial health, profitability ratios, balance sheet strength, and growth metrics. The combined rating reflects both perspectives for balanced insights.

Is VYNE a good stock to buy right now?

Based on our AI fundamental analysis in April 2026, VYNE Therapeutics Inc. has a STRONG SELL rating with 92% confidence. Review the strengths and risks sections above before making a decision. This is not investment advice.

Is VYNE stock overvalued or undervalued?

Valuation metrics for VYNE: ROE of -95.4% (sector avg: 15%), net margin of -4,646.1% (sector avg: 12%). Compare these metrics with sector averages to assess valuation.

Should I buy VYNE stock in 2026?

Our dual AI analysis gives VYNE Therapeutics Inc. a combined STRONG SELL rating for 2026. Revenue is data pending, with profitability at or below sector average. Always conduct your own research.

What is VYNE's free cash flow?

VYNE Therapeutics Inc.'s operating cash flow is $-33.1M, with capital expenditures of $0.0. FCF margin is -5,811.2%.

How does VYNE compare to other Healthcare stocks?

Vs Healthcare sector averages: Net margin -4,646.1% (avg: 12%), ROE -95.4% (avg: 15%), current ratio 12.53 (avg: 2).

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Disclaimer: This analysis is generated by Claude AI (Anthropic) and ChatGPT (OpenAI) based on publicly available SEC EDGAR filings. It does not include stock price data and should not be considered financial advice. All fundamental data is sourced from SEC public domain filings. Always conduct your own research and consult with a qualified financial advisor before making investment decisions.
Data Source: SEC EDGAR | Analysis Date: Apr 18, 2026 | Data as of: 2025-12-31 | Powered by Claude AI