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Talphera, Inc.. (TLPH) Stock Fundamental Analysis & AI Rating 2026

TLPH Nasdaq Pharmaceutical Preparations DE CIK: 0001427925
Recently Updated • Analysis: Apr 17, 2026 • SEC Data: 2025-12-31
STRONG SELL
92% Conf
Pending
Analysis scheduled

📊 TLPH Key Takeaways

Revenue: $28.0K
Net Margin: -51,035.7%
Free Cash Flow: $-11.4M
Current Ratio: 5.49x
Debt/Equity: 0.34x
EPS: $-0.10
AI Rating: STRONG SELL with 92% confidence
Talphera, Inc.. (TLPH) receives a STRONG SELL rating with 92% confidence from our AI fundamental analysis based on SEC 10-K filings. With revenue of $28.0K, net profit margin of -51,035.7%, and return on equity (ROE) of -83.9%, Talphera, Inc.. demonstrates mixed fundamentals in the Healthcare sector. Below is our complete TLPH stock analysis for 2026.

Is Talphera, Inc.. (TLPH) a Good Investment?

Claude

Talphera is a pre-revenue clinical-stage pharmaceutical company with virtually zero commercial revenue ($28K annually) while burning $11.4M in operating cash flow. With only $5.9M in cash and a 6-month runway at current burn rates, the company faces imminent capital requirement and execution risk without approved products generating meaningful revenue.

Why Buy Talphera, Inc.. Stock? TLPH Key Strengths

Claude
  • + Strong liquidity position with 5.49x current ratio and 5.18x quick ratio
  • + Conservative leverage with 0.34x debt-to-equity ratio
  • + Manageable absolute debt levels at $5.8M long-term debt against $17M equity

TLPH Stock Risks: Talphera, Inc.. Investment Risks

Claude
  • ! Negligible revenue base of $28K annually with massive -$13.5M operating loss
  • ! Critical cash burn of -$11.4M operating cash flow providing only ~6 month survival runway
  • ! Clinical-stage company with no approved revenue-generating products facing high execution risk
  • ! Negative margins: -48,157% operating margin and -51,035% net margin indicate severe operational distress
  • ! 10 insider Form 4 filings in 90 days suggest potential management instability or significant transactions

Key Metrics to Watch

Claude
  • * Cash runway and timing of next capital raise requirement
  • * Clinical trial progression and regulatory milestone achievements
  • * Monthly cash burn rate trends and operating cash flow acceleration toward profitability
  • * Any revenue inflection from product approvals or partnerships

Talphera, Inc.. (TLPH) Financial Metrics & Key Ratios

Revenue
$28.0K
Net Income
$-14.3M
EPS (Diluted)
$-0.10
Free Cash Flow
$-11.4M
Total Assets
$29.7M
Cash Position
$5.9M

💡 AI Analyst Insight

Strong liquidity with a 5.49x current ratio provides a solid financial cushion.

TLPH Profit Margin, ROE & Profitability Analysis

Gross Margin N/A
Operating Margin -48,157.1%
Net Margin -51,035.7%
ROE -83.9%
ROA -48.1%
FCF Margin -40,585.7%

TLPH vs Healthcare Sector: How Talphera, Inc.. Compares

How Talphera, Inc.. compares to Healthcare sector averages

Net Margin
TLPH -51,035.7%
vs
Sector Avg 12.0%
TLPH Sector
ROE
TLPH -83.9%
vs
Sector Avg 15.0%
TLPH Sector
Current Ratio
TLPH 5.5x
vs
Sector Avg 2.0x
TLPH Sector
Debt/Equity
TLPH 0.3x
vs
Sector Avg 0.6x
TLPH Sector

Sector benchmarks are approximate industry averages. Actual sector performance may vary.

Is Talphera, Inc.. Stock Overvalued? TLPH Valuation Analysis 2026

Based on fundamental analysis, Talphera, Inc.. has mixed fundamental signals relative to the Healthcare sector in 2026.

Return on Equity
-83.9%
Sector avg: 15%
Net Profit Margin
-51,035.7%
Sector avg: 12%
Revenue Growth
N/A
Year-over-year
Debt/Equity
0.34x
Sector avg: 0.6x

Note: This is a fundamental analysis based on SEC filings. For P/E ratio, price targets, and market-based valuation, consult financial data providers. This is not investment advice.

Talphera, Inc.. Balance Sheet: TLPH Debt, Cash & Liquidity

Current Ratio
5.49x
Quick Ratio
5.18x
Debt/Equity
0.34x
Debt/Assets
42.7%
Interest Coverage
N/A
Long-term Debt
$5.8M

TLPH Revenue & Earnings Growth: 5-Year Financial Trend

TLPH 5-year financial data: Year 2021: Revenue $5.4M, Net Income -$40.4M, EPS N/A. Year 2022: Revenue $2.8M, Net Income -$35.1M, EPS $-5.86. Year 2023: Revenue $651.0K, Net Income $47.8M, EPS $5.72. Year 2024: Revenue $651.0K, Net Income -$18.4M, EPS N/A. Year 2025: Revenue $28.0K, Net Income -$13.0M, EPS N/A.
Revenue
Net Income
EPS (right axis)

5-Year Trend Summary: Talphera, Inc..'s revenue has declined by 99% over the 5-year period, indicating business contraction. The most recent EPS of $5.72 reflects profitable operations.

TLPH Revenue Growth, EPS Growth & YoY Performance

Revenue Growth
N/A
Year-over-year
Net Income Growth
N/A
Year-over-year
EPS Growth
N/A
Earnings per share
FCF Margin
-40,585.7%
Free cash flow / Revenue

TLPH Quarterly Earnings & Performance

Quarterly financial performance data for Talphera, Inc.. including revenue, net income, and earnings per share.
Quarter Revenue Net Income EPS
Q3 2025 N/A -$2.6M N/A
Q2 2025 N/A -$2.6M N/A
Q1 2025 N/A -$2.6M $-0.10
Q3 2024 N/A -$1.4M N/A
Q2 2024 N/A -$3.8M N/A
Q3 2023 N/A -$1.4M $-0.08
Q2 2023 N/A -$4.4M $-0.40
Q3 2022 $507.0K -$6.8M $-0.94

Data sourced from SEC EDGAR 10-Q quarterly filings. Figures may represent quarterly or cumulative values.

Talphera, Inc.. Dividends, Buybacks & Capital Allocation

Operating Cash Flow
-$11.4M
Cash generated from operations
Dividends
None
No dividend program

TLPH SEC Filings: Latest 10-K & 10-Q Analysis

Access official SEC EDGAR filings for Talphera, Inc.. (CIK: 0001427925)

📋 Recent SEC Filings

Date Form Document Action
Apr 3, 2026 4 xslF345X06/form4-04032026_100412.xml View →
Apr 3, 2026 4 xslF345X06/form4-04032026_100414.xml View →
Apr 3, 2026 4 xslF345X06/form4-04032026_100457.xml View →
Apr 3, 2026 4 xslF345X06/form4-04032026_100455.xml View →
Mar 25, 2026 4 xslF345X06/form4-03252026_110351.xml View →

Frequently Asked Questions about TLPH

What is the AI rating for TLPH?

Talphera, Inc.. (TLPH) has an AI rating of STRONG SELL with 92% confidence, based on fundamental analysis of SEC EDGAR filings.

What are TLPH's key strengths?

Claude: Strong liquidity position with 5.49x current ratio and 5.18x quick ratio. Conservative leverage with 0.34x debt-to-equity ratio.

What are the risks of investing in TLPH?

Claude: Negligible revenue base of $28K annually with massive -$13.5M operating loss. Critical cash burn of -$11.4M operating cash flow providing only ~6 month survival runway.

What is TLPH's revenue and growth?

Talphera, Inc.. reported revenue of $28.0K.

Does TLPH pay dividends?

Talphera, Inc.. does not currently pay dividends.

Where can I find TLPH SEC filings?

Official SEC filings for Talphera, Inc.. (CIK: 0001427925) including 10-K, 10-Q, and 8-K reports are available on SEC EDGAR.

What is TLPH's EPS?

Talphera, Inc.. has a diluted EPS of $-0.10.

How is the AI analysis conducted?

Two independent AI systems — Claude (Anthropic) and ChatGPT (OpenAI) — analyze SEC EDGAR filings including 10-K annual reports and 10-Q quarterly reports. Each AI evaluates financial health, profitability ratios, balance sheet strength, and growth metrics. The combined rating reflects both perspectives for balanced insights.

Is TLPH a good stock to buy right now?

Based on our AI fundamental analysis in April 2026, Talphera, Inc.. has a STRONG SELL rating with 92% confidence. Review the strengths and risks sections above before making a decision. This is not investment advice.

Is TLPH stock overvalued or undervalued?

Valuation metrics for TLPH: ROE of -83.9% (sector avg: 15%), net margin of -51,035.7% (sector avg: 12%). Compare these metrics with sector averages to assess valuation.

Should I buy TLPH stock in 2026?

Our dual AI analysis gives Talphera, Inc.. a combined STRONG SELL rating for 2026. Revenue is data pending, with profitability at or below sector average. Always conduct your own research.

What is TLPH's free cash flow?

Talphera, Inc..'s operating cash flow is $-11.4M, with capital expenditures of $0.0. FCF margin is -40,585.7%.

How does TLPH compare to other Healthcare stocks?

Vs Healthcare sector averages: Net margin -51,035.7% (avg: 12%), ROE -83.9% (avg: 15%), current ratio 5.49 (avg: 2).

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Disclaimer: This analysis is generated by Claude AI (Anthropic) and ChatGPT (OpenAI) based on publicly available SEC EDGAR filings. It does not include stock price data and should not be considered financial advice. All fundamental data is sourced from SEC public domain filings. Always conduct your own research and consult with a qualified financial advisor before making investment decisions.
Data Source: SEC EDGAR | Analysis Date: Apr 17, 2026 | Data as of: 2025-12-31 | Powered by Claude AI