← Back to All US Stocks

Silence Therapeutics plc (SLNCF) Stock Fundamental Analysis & AI Rating 2026

SLNCF Nasdaq Pharmaceutical Preparations X0 CIK: 0001479615
Recently Updated • Analysis: Apr 16, 2026 • SEC Data: 2025-12-31
STRONG SELL
95% Conf
Pending
Analysis scheduled

📊 SLNCF Key Takeaways

Revenue: $559.0K
Net Margin: -15,851.9%
Free Cash Flow: $-62.3M
Current Ratio: 8.72x
Debt/Equity: 0.00x
EPS: $-0.63
AI Rating: STRONG SELL with 95% confidence
Silence Therapeutics plc (SLNCF) receives a STRONG SELL rating with 95% confidence from our AI fundamental analysis based on SEC 10-K filings. With revenue of $559.0K, net profit margin of -15,851.9%, and return on equity (ROE) of -142.2%, Silence Therapeutics plc demonstrates mixed fundamentals in the Healthcare sector. Below is our complete SLNCF stock analysis for 2026.

Is Silence Therapeutics plc (SLNCF) a Good Investment?

Claude

Company experiencing catastrophic business deterioration with 98.7% revenue collapse and -62.3M annual operating cash burn against only 11.3M cash reserves (~2 months runway). Massive operating losses of -91.1M indicate fundamental product/business failure with no visible path to profitability.

Why Buy Silence Therapeutics plc Stock? SLNCF Key Strengths

Claude
  • + Zero debt burden provides financial flexibility
  • + Positive gross margin of 61.5% on remaining product sales
  • + Stockholders equity of 62.3M provides book value cushion

SLNCF Stock Risks: Silence Therapeutics plc Investment Risks

Claude
  • ! Critical cash runway of ~2 months at current -62.3M annual burn rate
  • ! 98.7% YoY revenue collapse suggests loss of primary product or failed pipeline
  • ! Operating losses of -91.1M unsustainable relative to 559K revenue base
  • ! No evidence of near-term catalysts for revenue recovery or profitability

Key Metrics to Watch

Claude
  • * Quarterly operating cash burn rate and cash balance depletion
  • * Revenue stabilization or pipeline announcements indicating business recovery
  • * Cost restructuring progress and timeline to cash flow breakeven

Silence Therapeutics plc (SLNCF) Financial Metrics & Key Ratios

Revenue
$559.0K
Net Income
$-88.6M
EPS (Diluted)
$-0.63
Free Cash Flow
$-62.3M
Total Assets
$131.4M
Cash Position
$11.3M

💡 AI Analyst Insight

Strong liquidity with a 8.72x current ratio provides a solid financial cushion.

SLNCF Profit Margin, ROE & Profitability Analysis

Gross Margin 61.5%
Operating Margin -16,292.8%
Net Margin -15,851.9%
ROE -142.2%
ROA -67.4%
FCF Margin -11,149.6%

SLNCF vs Healthcare Sector: How Silence Therapeutics plc Compares

How Silence Therapeutics plc compares to Healthcare sector averages

Net Margin
SLNCF -15,851.9%
vs
Sector Avg 12.0%
SLNCF Sector
ROE
SLNCF -142.2%
vs
Sector Avg 15.0%
SLNCF Sector
Current Ratio
SLNCF 8.7x
vs
Sector Avg 2.0x
SLNCF Sector
Debt/Equity
SLNCF 0.0x
vs
Sector Avg 0.6x
SLNCF Sector

Sector benchmarks are approximate industry averages. Actual sector performance may vary.

Is Silence Therapeutics plc Stock Overvalued? SLNCF Valuation Analysis 2026

Based on fundamental analysis, Silence Therapeutics plc has mixed fundamental signals relative to the Healthcare sector in 2026.

Return on Equity
-142.2%
Sector avg: 15%
Net Profit Margin
-15,851.9%
Sector avg: 12%
Revenue Growth
N/A
Year-over-year
Debt/Equity
0.00x
Sector avg: 0.6x

Note: This is a fundamental analysis based on SEC filings. For P/E ratio, price targets, and market-based valuation, consult financial data providers. This is not investment advice.

Silence Therapeutics plc Balance Sheet: SLNCF Debt, Cash & Liquidity

Current Ratio
8.72x
Quick Ratio
8.72x
Debt/Equity
0.00x
Debt/Assets
52.6%
Interest Coverage
N/A
Long-term Debt
N/A

SLNCF Revenue & Earnings Growth: 5-Year Financial Trend

SLNCF 5-year financial data: Year 2024: Revenue $43.3M, Net Income -$50.3M, EPS $-0.52. Year 2025: Revenue $43.3M, Net Income -$45.3M, EPS $-0.33.
Revenue
Net Income
EPS (right axis)

5-Year Trend Summary: Silence Therapeutics plc's revenue has remained relatively flat over the 5-year period, with a 0% decline. The most recent EPS of $-0.33 indicates the company is currently unprofitable.

SLNCF Revenue Growth, EPS Growth & YoY Performance

Revenue Growth
N/A
Year-over-year
Net Income Growth
N/A
Year-over-year
EPS Growth
N/A
Earnings per share
FCF Margin
-11,149.6%
Free cash flow / Revenue

SLNCF Quarterly Earnings & Performance

Quarterly financial performance data for Silence Therapeutics plc including revenue, net income, and earnings per share.
Quarter Revenue Net Income EPS
Q3 2025 $159.0K -$2.3M $-0.15
Q2 2025 $224.0K -$2.3M $-0.14
Q1 2025 $142.0K -$2.3M $-0.02

Data sourced from SEC EDGAR 10-Q quarterly filings. Figures may represent quarterly or cumulative values.

Silence Therapeutics plc Dividends, Buybacks & Capital Allocation

Operating Cash Flow
-$62.3M
Cash generated from operations
Capital Expenditures
$55.0K
Investment in assets
Dividends
None
No dividend program

SLNCF SEC Filings: Latest 10-K & 10-Q Analysis

Access official SEC EDGAR filings for Silence Therapeutics plc (CIK: 0001479615)

📋 Recent SEC Filings

Date Form Document Action
Mar 5, 2026 10-K sln-20251231.htm View →
Mar 5, 2026 8-K sln-20260305.htm View →
Feb 13, 2026 4 xslF345X05/tm266179-1_4seq1.xml View →
Jan 6, 2026 4 xslF345X05/form4-01062026_040108.xml View →
Jan 6, 2026 4 xslF345X05/form4-01062026_040107.xml View →

Frequently Asked Questions about SLNCF

What is the AI rating for SLNCF?

Silence Therapeutics plc (SLNCF) has an AI rating of STRONG SELL with 95% confidence, based on fundamental analysis of SEC EDGAR filings.

What are SLNCF's key strengths?

Claude: Zero debt burden provides financial flexibility. Positive gross margin of 61.5% on remaining product sales.

What are the risks of investing in SLNCF?

Claude: Critical cash runway of ~2 months at current -62.3M annual burn rate. 98.7% YoY revenue collapse suggests loss of primary product or failed pipeline.

What is SLNCF's revenue and growth?

Silence Therapeutics plc reported revenue of $559.0K.

Does SLNCF pay dividends?

Silence Therapeutics plc does not currently pay dividends.

Where can I find SLNCF SEC filings?

Official SEC filings for Silence Therapeutics plc (CIK: 0001479615) including 10-K, 10-Q, and 8-K reports are available on SEC EDGAR.

What is SLNCF's EPS?

Silence Therapeutics plc has a diluted EPS of $-0.63.

How is the AI analysis conducted?

Two independent AI systems — Claude (Anthropic) and ChatGPT (OpenAI) — analyze SEC EDGAR filings including 10-K annual reports and 10-Q quarterly reports. Each AI evaluates financial health, profitability ratios, balance sheet strength, and growth metrics. The combined rating reflects both perspectives for balanced insights.

Is SLNCF a good stock to buy right now?

Based on our AI fundamental analysis in April 2026, Silence Therapeutics plc has a STRONG SELL rating with 95% confidence. Review the strengths and risks sections above before making a decision. This is not investment advice.

Is SLNCF stock overvalued or undervalued?

Valuation metrics for SLNCF: ROE of -142.2% (sector avg: 15%), net margin of -15,851.9% (sector avg: 12%). Compare these metrics with sector averages to assess valuation.

Should I buy SLNCF stock in 2026?

Our dual AI analysis gives Silence Therapeutics plc a combined STRONG SELL rating for 2026. Revenue is data pending, with profitability at or below sector average. Always conduct your own research.

What is SLNCF's free cash flow?

Silence Therapeutics plc's operating cash flow is $-62.3M, with capital expenditures of $55.0K. FCF margin is -11,149.6%.

How does SLNCF compare to other Healthcare stocks?

Vs Healthcare sector averages: Net margin -15,851.9% (avg: 12%), ROE -142.2% (avg: 15%), current ratio 8.72 (avg: 2).

Top Rated Stocks
NSSC 92% MLI 92% MELI 92% MDXG 92% MANH 92% INVA 92% GGG 92% GCT 92% FTNT 92% FSLR 92%
Sector: All Healthcare Stocks →
Disclaimer: This analysis is generated by Claude AI (Anthropic) and ChatGPT (OpenAI) based on publicly available SEC EDGAR filings. It does not include stock price data and should not be considered financial advice. All fundamental data is sourced from SEC public domain filings. Always conduct your own research and consult with a qualified financial advisor before making investment decisions.
Data Source: SEC EDGAR | Analysis Date: Apr 16, 2026 | Data as of: 2025-12-31 | Powered by Claude AI