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Personalis, Inc. (PSNL) Fundamental Analysis & AI Grade 2026

PSNL Nasdaq Services-Medical Laboratories DE CIK: 0001527753
Updated This Month • Analysis: May 8, 2026 • SEC Data: 2026-03-31
Combined AI Grade
D
85% Confidence
N/A
D
85% Conf
Pending
Analysis scheduled

📊 PSNL Key Takeaways

Revenue: $15.5M
Net Margin: -194.1%
Free Cash Flow: $-25.7M
Current Ratio: 6.61x
Debt/Equity: 0.08x
EPS: $-0.29
AI Grade: D with 85% confidence
Personalis, Inc. (PSNL) receives a D fundamental grade with 85% confidence from our AI analysis based on SEC 10-K filings. With revenue of $15.5M, net profit margin of -194.1%, and return on equity (ROE) of -11.8%, Personalis, Inc. demonstrates mixed fundamentals in the Healthcare sector. Below is our complete PSNL stock analysis for 2026.

Is Personalis, Inc. (PSNL) a Good Investment?

Claude

Personalis exhibits severe operational deterioration with declining revenue (-17.7% YoY), substantial operating losses (-207.9% margin), and negative free cash flow of -$25.7M. Despite a strong balance sheet with $73.6M cash and low leverage, the company is burning capital at an unsustainable rate with no visible path to profitability, indicating fundamental business model execution failure.

Personalis, Inc. Key Strengths (PSNL)

Claude
  • + Strong liquidity with 6.61x current ratio and $73.6M cash reserves providing operational runway
  • + Reasonable gross margin of 42.4% indicating viable core business economics at gross profit level
  • + Conservative capital structure with 0.08x debt-to-equity ratio limiting financial distress risk

PSNL Stock Risks: Personalis, Inc. Investment Risks

Claude
  • ! Revenue contraction of 17.7% YoY indicates market share loss, demand destruction, or competitive pressures
  • ! Massive operating losses (-32.2M) and negative operating cash flow (-22.5M) showing deteriorating unit economics
  • ! Negative free cash flow of -$25.7M will deplete $73.6M cash reserves in approximately 3 years absent operational improvement

Key Metrics to Watch

Claude
  • * Revenue stabilization and trajectory toward positive YoY growth
  • * Operating cash flow path to positive territory as primary profitability indicator
  • * Operating margin improvement toward breakeven threshold
  • * Gross margin maintenance to confirm core business viability

Personalis, Inc. (PSNL) Financial Metrics & Key Ratios

Revenue
$15.5M
Net Income
$-30.0M
EPS (Diluted)
$-0.29
Free Cash Flow
$-25.7M
Total Assets
$325.4M
Cash Position
$73.6M

💡 AI Analyst Insight

Strong liquidity with a 6.61x current ratio provides a solid financial cushion.

PSNL Profit Margin, ROE & Profitability Analysis

Gross Margin 42.4%
Operating Margin -207.9%
Net Margin -194.1%
ROE -11.8%
ROA -9.2%
FCF Margin -165.9%

PSNL vs Healthcare Sector: How Personalis, Inc. Compares

How Personalis, Inc. compares to Healthcare sector averages

Net Margin
PSNL -194.1%
vs
Sector Avg 12.0%
PSNL Sector
ROE
PSNL -11.8%
vs
Sector Avg 15.0%
PSNL Sector
Current Ratio
PSNL 6.6x
vs
Sector Avg 2.0x
PSNL Sector
Debt/Equity
PSNL 0.1x
vs
Sector Avg 0.6x
PSNL Sector

Sector benchmarks are approximate industry averages. Actual sector performance may vary.

Is Personalis, Inc. Stock Overvalued? PSNL Valuation Analysis 2026

Based on fundamental analysis, Personalis, Inc. has mixed fundamental signals relative to the Healthcare sector in 2026.

Return on Equity
-11.8%
Sector avg: 15%
Net Profit Margin
-194.1%
Sector avg: 12%
Revenue Growth
N/A
Year-over-year
Debt/Equity
0.08x
Sector avg: 0.6x

Note: This is a fundamental analysis based on SEC filings. For P/E ratio, price targets, and market-based valuation, consult financial data providers. This is not investment advice.

Personalis, Inc. Balance Sheet: PSNL Debt, Cash & Liquidity

Current Ratio
6.61x
Quick Ratio
6.61x
Debt/Equity
0.08x
Debt/Assets
21.7%
Interest Coverage
-684.28x
Long-term Debt
$20.0M

PSNL Revenue & Earnings Growth: 5-Year Financial Trend

PSNL 5-year financial data: Year 2021: Revenue $85.5M, Net Income -$25.1M, EPS N/A. Year 2022: Revenue $85.5M, Net Income -$41.3M, EPS $-1.20. Year 2023: Revenue $85.5M, Net Income -$65.2M, EPS $-1.49. Year 2024: Revenue $84.6M, Net Income -$108.3M, EPS $-2.25. Year 2025: Revenue $84.6M, Net Income -$81.3M, EPS $-1.37.
Revenue
Net Income
EPS (right axis)

5-Year Trend Summary: Personalis, Inc.'s revenue has remained relatively flat over the 5-year period, with a 1% decline. The most recent EPS of $-1.37 indicates the company is currently unprofitable.

PSNL Revenue Growth, EPS Growth & YoY Performance

Revenue Growth
N/A
Year-over-year
Net Income Growth
N/A
Year-over-year
EPS Growth
N/A
Earnings per share
FCF Margin
-165.9%
Free cash flow / Revenue

PSNL Quarterly Earnings & Performance

Quarterly financial performance data for Personalis, Inc. including revenue, net income, and earnings per share.
Quarter Revenue Net Income EPS
Q1 2026 $15.5M -$15.8M $-0.18
Q3 2025 $14.5M -$21.7M $-0.24
Q2 2025 $17.2M -$12.8M $-0.23
Q1 2025 $19.5M -$13.0M $-0.18
Q3 2024 $18.2M -$29.1M $-0.60
Q2 2024 $16.7M -$12.8M $-0.24
Q1 2024 $18.9M -$13.0M $-0.26
Q3 2023 $14.9M -$26.5M $-0.58

Data sourced from SEC EDGAR 10-Q quarterly filings. Figures may represent quarterly or cumulative values.

Personalis, Inc. Dividends, Buybacks & Capital Allocation

Operating Cash Flow
-$22.5M
Cash generated from operations
Capital Expenditures
$3.2M
Investment in assets
Dividends
None
No dividend program

PSNL SEC Filings: Latest 10-K & 10-Q Analysis

Access official SEC EDGAR filings for Personalis, Inc. (CIK: 0001527753)

📋 Recent SEC Filings

Date Form Document Action
May 29, 2026 4 xslF345X06/form4-05292026_080501.xml View →
May 29, 2026 4 xslF345X06/form4-05302026_120502.xml View →
May 20, 2026 8-K psnl-20260519.htm View →
May 14, 2026 4 xslF345X06/form4-05142026_090542.xml View →
May 14, 2026 4 xslF345X06/form4-05142026_090531.xml View →

Frequently Asked Questions about PSNL

What is the AI rating for PSNL?

Personalis, Inc. (PSNL) has an AI grade of D with 85% confidence, based on fundamental analysis of SEC EDGAR filings.

What are PSNL's key strengths?

Claude: Strong liquidity with 6.61x current ratio and $73.6M cash reserves providing operational runway. Reasonable gross margin of 42.4% indicating viable core business economics at gross profit level.

What are the risks of investing in PSNL?

Claude: Revenue contraction of 17.7% YoY indicates market share loss, demand destruction, or competitive pressures. Massive operating losses (-32.2M) and negative operating cash flow (-22.5M) showing deteriorating unit economics.

What is PSNL's revenue and growth?

Personalis, Inc. reported revenue of $15.5M.

Does PSNL pay dividends?

Personalis, Inc. does not currently pay dividends.

Where can I find PSNL SEC filings?

Official SEC filings for Personalis, Inc. (CIK: 0001527753) including 10-K, 10-Q, and 8-K reports are available on SEC EDGAR.

What is PSNL's EPS?

Personalis, Inc. has a diluted EPS of $-0.29.

How is the AI analysis conducted?

Two independent AI systems — Claude (Anthropic) and ChatGPT (OpenAI) — analyze SEC EDGAR filings including 10-K annual reports and 10-Q quarterly reports. Each AI evaluates financial health, profitability ratios, balance sheet strength, and growth metrics. The combined grade reflects both perspectives for balanced insights.

What is PSNL's fundamental grade?

Based on our AI fundamental analysis in May 2026, Personalis, Inc. has a D grade with 85% confidence. Review the strengths and risks sections above for full context. This is not investment advice.

Is PSNL stock overvalued or undervalued?

Valuation metrics for PSNL: ROE of -11.8% (sector avg: 15%), net margin of -194.1% (sector avg: 12%). Compare these metrics with sector averages to assess valuation.

What is PSNL's AI grade for 2026?

Our dual AI analysis gives Personalis, Inc. a combined D grade for 2026. Revenue is data pending, with profitability at or below sector average. Always conduct your own research.

What is PSNL's free cash flow?

Personalis, Inc.'s operating cash flow is $-22.5M, with capital expenditures of $3.2M. FCF margin is -165.9%.

How does PSNL compare to other Healthcare stocks?

Vs Healthcare sector averages: Net margin -194.1% (avg: 12%), ROE -11.8% (avg: 15%), current ratio 6.61 (avg: 2).

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Disclaimer: This analysis is generated by Claude AI (Anthropic) and ChatGPT (OpenAI) based on publicly available SEC EDGAR filings. It does not include stock price data and should not be considered financial advice. All fundamental data is sourced from SEC public domain filings. Always conduct your own research and consult with a qualified financial advisor before making investment decisions.
Data Source: SEC EDGAR | Analysis Date: May 8, 2026 | Data as of: 2026-03-31 | Powered by Claude AI