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Protalix BioTherapeutics, Inc. (PLX) Stock Fundamental Analysis & AI Rating 2026

PLX NYSE Biological Products, (No Diagnostic Substances) DE CIK: 0001006281
Recently Updated • Analysis: Apr 14, 2026 • SEC Data: 2025-12-31
STRONG SELL
87% Conf
Pending
Analysis scheduled

📊 PLX Key Takeaways

Revenue: $52.7M
Net Margin: -12.5%
Free Cash Flow: $-13.6M
Current Ratio: 2.51x
Debt/Equity: 0.02x
EPS: $-0.08
AI Rating: STRONG SELL with 87% confidence
Protalix BioTherapeutics, Inc. (PLX) receives a STRONG SELL rating with 87% confidence from our AI fundamental analysis based on SEC 10-K filings. With revenue of $52.7M, net profit margin of -12.5%, and return on equity (ROE) of -13.7%, Protalix BioTherapeutics, Inc. demonstrates mixed fundamentals in the Healthcare sector. Below is our complete PLX stock analysis for 2026.

Is Protalix BioTherapeutics, Inc. (PLX) a Good Investment?

Claude

Protalix faces severe operational headwinds with declining revenue (-1.2% YoY), devastating profitability metrics (0.4% gross margin, -12.5% net margin), and unsustainable cash burn of $12M annually against only $14.7M in cash reserves, implying ~1.2 years of runway. Despite minimal leverage and adequate liquidity ratios, the company's deteriorating commercial performance and inability to generate positive cash flow from operations present existential risk without significant operational improvement or capital infusion.

Why Buy Protalix BioTherapeutics, Inc. Stock? PLX Key Strengths

Claude
  • + Very low leverage with minimal debt burden (Debt/Equity: 0.02x, only $912K long-term debt)
  • + Healthy short-term liquidity ratios (Current: 2.51x, Quick: 1.54x) provide near-term operational flexibility
  • + Meaningful asset base of $82.3M and positive stockholders' equity of $48.2M provide some balance sheet cushion

PLX Stock Risks: Protalix BioTherapeutics, Inc. Investment Risks

Claude
  • ! Revenue decline of 1.2% YoY in biotech sector indicates failing commercialization and market demand
  • ! Catastrophic cash burn: $12M operating outflow annually with only $14.7M cash (approximately 1.2 years runway)
  • ! Unsustainable profitability: 0.4% gross margin suggests severe production/pricing dysfunction; -10.4% operating margin indicates operational losses are structural not cyclical
  • ! No insider purchases in 90 days suggests management lacks confidence in turnaround prospects
  • ! Free cash flow of -$13.6M combined with declining revenue creates urgent financing needs

Key Metrics to Watch

Claude
  • * Quarterly revenue trend and sequential growth rate (current decline trajectory is critical)
  • * Gross margin improvement (0.4% is abnormally low and unsustainable)
  • * Operating cash flow burn rate and months of cash runway remaining
  • * Pipeline development progress and regulatory milestones for product development
  • * Capital raising activities and dilution impact from equity financing needs

Protalix BioTherapeutics, Inc. (PLX) Financial Metrics & Key Ratios

Revenue
$52.7M
Net Income
$-6.6M
EPS (Diluted)
$-0.08
Free Cash Flow
$-13.6M
Total Assets
$82.3M
Cash Position
$14.7M

💡 AI Analyst Insight

Strong liquidity with a 2.51x current ratio provides a solid financial cushion.

PLX Profit Margin, ROE & Profitability Analysis

Gross Margin 0.4%
Operating Margin -10.4%
Net Margin -12.5%
ROE -13.7%
ROA -8.0%
FCF Margin -25.8%

PLX vs Healthcare Sector: How Protalix BioTherapeutics, Inc. Compares

How Protalix BioTherapeutics, Inc. compares to Healthcare sector averages

Net Margin
PLX -12.5%
vs
Sector Avg 12.0%
PLX Sector
ROE
PLX -13.7%
vs
Sector Avg 15.0%
PLX Sector
Current Ratio
PLX 2.5x
vs
Sector Avg 2.0x
PLX Sector
Debt/Equity
PLX 0.0x
vs
Sector Avg 0.6x
PLX Sector

Sector benchmarks are approximate industry averages. Actual sector performance may vary.

Is Protalix BioTherapeutics, Inc. Stock Overvalued? PLX Valuation Analysis 2026

Based on fundamental analysis, Protalix BioTherapeutics, Inc. has mixed fundamental signals relative to the Healthcare sector in 2026.

Return on Equity
-13.7%
Sector avg: 15%
Net Profit Margin
-12.5%
Sector avg: 12%
Revenue Growth
N/A
Year-over-year
Debt/Equity
0.02x
Sector avg: 0.6x

Note: This is a fundamental analysis based on SEC filings. For P/E ratio, price targets, and market-based valuation, consult financial data providers. This is not investment advice.

Protalix BioTherapeutics, Inc. Balance Sheet: PLX Debt, Cash & Liquidity

Current Ratio
2.51x
Quick Ratio
1.54x
Debt/Equity
0.02x
Debt/Assets
41.4%
Interest Coverage
-1.55x
Long-term Debt
$912.0K

PLX Revenue & Earnings Growth: 5-Year Financial Trend

PLX 5-year financial data: Year 2021: Revenue $62.9M, Net Income -$18.3M, EPS $-1.23. Year 2022: Revenue $62.9M, Net Income -$6.5M, EPS $-0.22. Year 2023: Revenue $65.5M, Net Income -$27.6M, EPS $-0.62. Year 2024: Revenue $65.5M, Net Income -$14.9M, EPS $-0.31. Year 2025: Revenue $65.5M, Net Income $8.3M, EPS $0.09.
Revenue
Net Income
EPS (right axis)

5-Year Trend Summary: Protalix BioTherapeutics, Inc.'s revenue has shown modest growth of 4% over the 5-year period. The most recent EPS of $0.09 reflects profitable operations.

PLX Revenue Growth, EPS Growth & YoY Performance

Revenue Growth
N/A
Year-over-year
Net Income Growth
N/A
Year-over-year
EPS Growth
N/A
Earnings per share
FCF Margin
-25.8%
Free cash flow / Revenue

PLX Quarterly Earnings & Performance

Quarterly financial performance data for Protalix BioTherapeutics, Inc. including revenue, net income, and earnings per share.
Quarter Revenue Net Income EPS
Q3 2025 $17.9M -$1.1M $-0.01
Q2 2025 $13.5M $164.0K $0.00
Q1 2025 $3.7M -$3.6M $-0.05
Q3 2024 $10.3M -$1.9M $0.03
Q2 2024 $13.5M -$2.2M $-0.03
Q1 2024 $3.7M -$3.1M $-0.05
Q3 2023 $10.3M -$1.9M $-0.04
Q2 2023 $8.8M -$5.3M $-0.11

Data sourced from SEC EDGAR 10-Q quarterly filings. Figures may represent quarterly or cumulative values.

Protalix BioTherapeutics, Inc. Dividends, Buybacks & Capital Allocation

Operating Cash Flow
-$12.0M
Cash generated from operations
Capital Expenditures
$1.6M
Investment in assets
Dividends
None
No dividend program

PLX SEC Filings: Latest 10-K & 10-Q Analysis

Access official SEC EDGAR filings for Protalix BioTherapeutics, Inc. (CIK: 0001006281)

📋 Recent SEC Filings

Date Form Document Action
Mar 18, 2026 10-K plx-20251231x10k.htm View →
Mar 18, 2026 8-K plx-20260318x8k.htm View →
Mar 9, 2026 8-K plx-20260309x8k.htm View →
Feb 11, 2026 8-K plx-20260211x8k.htm View →
Jan 30, 2026 8-K tm264565d1_8k.htm View →

Frequently Asked Questions about PLX

What is the AI rating for PLX?

Protalix BioTherapeutics, Inc. (PLX) has an AI rating of STRONG SELL with 87% confidence, based on fundamental analysis of SEC EDGAR filings.

What are PLX's key strengths?

Claude: Very low leverage with minimal debt burden (Debt/Equity: 0.02x, only $912K long-term debt). Healthy short-term liquidity ratios (Current: 2.51x, Quick: 1.54x) provide near-term operational flexibility.

What are the risks of investing in PLX?

Claude: Revenue decline of 1.2% YoY in biotech sector indicates failing commercialization and market demand. Catastrophic cash burn: $12M operating outflow annually with only $14.7M cash (approximately 1.2 years runway).

What is PLX's revenue and growth?

Protalix BioTherapeutics, Inc. reported revenue of $52.7M.

Does PLX pay dividends?

Protalix BioTherapeutics, Inc. does not currently pay dividends.

Where can I find PLX SEC filings?

Official SEC filings for Protalix BioTherapeutics, Inc. (CIK: 0001006281) including 10-K, 10-Q, and 8-K reports are available on SEC EDGAR.

What is PLX's EPS?

Protalix BioTherapeutics, Inc. has a diluted EPS of $-0.08.

How is the AI analysis conducted?

Two independent AI systems — Claude (Anthropic) and ChatGPT (OpenAI) — analyze SEC EDGAR filings including 10-K annual reports and 10-Q quarterly reports. Each AI evaluates financial health, profitability ratios, balance sheet strength, and growth metrics. The combined rating reflects both perspectives for balanced insights.

Is PLX a good stock to buy right now?

Based on our AI fundamental analysis in April 2026, Protalix BioTherapeutics, Inc. has a STRONG SELL rating with 87% confidence. Review the strengths and risks sections above before making a decision. This is not investment advice.

Is PLX stock overvalued or undervalued?

Valuation metrics for PLX: ROE of -13.7% (sector avg: 15%), net margin of -12.5% (sector avg: 12%). Compare these metrics with sector averages to assess valuation.

Should I buy PLX stock in 2026?

Our dual AI analysis gives Protalix BioTherapeutics, Inc. a combined STRONG SELL rating for 2026. Revenue is data pending, with profitability at or below sector average. Always conduct your own research.

What is PLX's free cash flow?

Protalix BioTherapeutics, Inc.'s operating cash flow is $-12.0M, with capital expenditures of $1.6M. FCF margin is -25.8%.

How does PLX compare to other Healthcare stocks?

Vs Healthcare sector averages: Net margin -12.5% (avg: 12%), ROE -13.7% (avg: 15%), current ratio 2.51 (avg: 2).

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Disclaimer: This analysis is generated by Claude AI (Anthropic) and ChatGPT (OpenAI) based on publicly available SEC EDGAR filings. It does not include stock price data and should not be considered financial advice. All fundamental data is sourced from SEC public domain filings. Always conduct your own research and consult with a qualified financial advisor before making investment decisions.
Data Source: SEC EDGAR | Analysis Date: Apr 14, 2026 | Data as of: 2025-12-31 | Powered by Claude AI