← Back to All US Stocks

Puma Biotechnology, Inc.. (PBYI) Fundamental Analysis & AI Grade 2026

PBYI Nasdaq Pharmaceutical Preparations DE CIK: 0001401667
Updated This Month • Analysis: May 9, 2026 • SEC Data: 2026-03-31
Combined AI Grade
C
75% Confidence
N/A
C
75% Conf
Pending
Analysis scheduled

📊 PBYI Key Takeaways

Revenue: $44.8M
Net Margin: -8.4%
Free Cash Flow: $15.4M
Current Ratio: 2.38x
Debt/Equity: 0.09x
EPS: $-0.07
AI Grade: C with 75% confidence
Puma Biotechnology, Inc.. (PBYI) receives a C fundamental grade with 75% confidence from our AI analysis based on SEC 10-K filings. With revenue of $44.8M, net profit margin of -8.4%, and return on equity (ROE) of -2.9%, Puma Biotechnology, Inc.. demonstrates mixed fundamentals in the Healthcare sector. Below is our complete PBYI stock analysis for 2026.

Is Puma Biotechnology, Inc.. (PBYI) a Good Investment?

Claude

PBYI is currently unprofitable with negative operating income (-$3.8M) and flat revenue (-0.9% YoY), presenting material fundamental challenges for a pharmaceutical company that typically requires growth to sustain operations. While the company maintains strong liquidity (2.38x current ratio) and positive free cash flow ($15.4M), these cannot offset the lack of revenue growth and persistent operating losses. Without evidence of a turnaround in profitability or revenue acceleration, the business model appears pressured despite adequate balance sheet strength.

Puma Biotechnology, Inc.. Key Strengths (PBYI)

Claude
  • + Strong positive free cash flow of $15.4M with 34.4% FCF margin, providing operational cash generation despite net losses
  • + Excellent liquidity position with current ratio of 2.38x and $36.2M in cash equivalents
  • + Conservative financial structure with very low leverage (0.09x Debt/Equity) and manageable $11.3M long-term debt

PBYI Stock Risks: Puma Biotechnology, Inc.. Investment Risks

Claude
  • ! Currently unprofitable with negative operating margin (-8.5%) and negative net income (-$3.8M); negative interest coverage (-1.1x) indicates inability to cover interest from operations
  • ! Revenue stagnation at -0.9% YoY decline with no visible growth momentum, highly concerning for pharmaceutical sector requiring expansion to offset R&D costs
  • ! Negative returns on equity (-2.9%) and assets (-1.9%) indicate capital destruction; unclear path to profitability with current business trajectory

Key Metrics to Watch

Claude
  • * Quarterly revenue trend and growth rate inflection
  • * Operating margin improvement timeline and path to positive EBITDA
  • * Free cash flow sustainability and monthly cash burn rate to estimate runway
  • * Product pipeline advancement, clinical trial results, and regulatory approvals

Puma Biotechnology, Inc.. (PBYI) Financial Metrics & Key Ratios

Revenue
$44.8M
Net Income
$-3.8M
EPS (Diluted)
$-0.07
Free Cash Flow
$15.4M
Total Assets
$192.7M
Cash Position
$36.2M

💡 AI Analyst Insight

The 34.4% free cash flow margin provides substantial flexibility for dividends, buybacks, and strategic investments. Strong liquidity with a 2.38x current ratio provides a solid financial cushion.

PBYI Profit Margin, ROE & Profitability Analysis

Gross Margin N/A
Operating Margin -8.5%
Net Margin -8.4%
ROE -2.9%
ROA -1.9%
FCF Margin 34.4%

PBYI vs Healthcare Sector: How Puma Biotechnology, Inc.. Compares

How Puma Biotechnology, Inc.. compares to Healthcare sector averages

Net Margin
PBYI -8.4%
vs
Sector Avg 12.0%
PBYI Sector
ROE
PBYI -2.9%
vs
Sector Avg 15.0%
PBYI Sector
Current Ratio
PBYI 2.4x
vs
Sector Avg 2.0x
PBYI Sector
Debt/Equity
PBYI 0.1x
vs
Sector Avg 0.6x
PBYI Sector

Sector benchmarks are approximate industry averages. Actual sector performance may vary.

Is Puma Biotechnology, Inc.. Stock Overvalued? PBYI Valuation Analysis 2026

Based on fundamental analysis, Puma Biotechnology, Inc.. has mixed fundamental signals relative to the Healthcare sector in 2026.

Return on Equity
-2.9%
Sector avg: 15%
Net Profit Margin
-8.4%
Sector avg: 12%
Revenue Growth
N/A
Year-over-year
Debt/Equity
0.09x
Sector avg: 0.6x

Note: This is a fundamental analysis based on SEC filings. For P/E ratio, price targets, and market-based valuation, consult financial data providers. This is not investment advice.

Puma Biotechnology, Inc.. Balance Sheet: PBYI Debt, Cash & Liquidity

Current Ratio
2.38x
Quick Ratio
2.24x
Debt/Equity
0.09x
Debt/Assets
33.4%
Interest Coverage
-1.14x
Long-term Debt
$11.3M

PBYI Revenue & Earnings Growth: 5-Year Financial Trend

PBYI 5-year financial data: Year 2021: Revenue $272.3M, Net Income -$75.6M, EPS N/A. Year 2022: Revenue $253.2M, Net Income -$60.0M, EPS $-1.52. Year 2023: Revenue $253.2M, Net Income -$29.1M, EPS $-0.72. Year 2024: Revenue $235.6M, Net Income $2.0K, EPS $0.00. Year 2025: Revenue $235.6M, Net Income $21.6M, EPS $0.45.
Revenue
Net Income
EPS (right axis)

5-Year Trend Summary: Puma Biotechnology, Inc..'s revenue has declined by 13% over the 5-year period, indicating business contraction. The most recent EPS of $0.45 reflects profitable operations.

PBYI Revenue Growth, EPS Growth & YoY Performance

Revenue Growth
N/A
Year-over-year
Net Income Growth
N/A
Year-over-year
EPS Growth
N/A
Earnings per share
FCF Margin
34.4%
Free cash flow / Revenue

PBYI Quarterly Earnings & Performance

Quarterly financial performance data for Puma Biotechnology, Inc.. including revenue, net income, and earnings per share.
Quarter Revenue Net Income EPS
Q1 2026 $44.8M $3.0M $0.06
Q3 2025 $54.5M $8.8M $0.17
Q2 2025 $47.1M -$4.5M $-0.09
Q1 2025 $43.8M $3.0M $0.06
Q3 2024 $56.1M $5.8M $0.12
Q2 2024 $47.1M $2.1M $0.05
Q1 2024 $43.8M $1.4M $0.03
Q3 2023 $56.1M -$360.0K $-0.01

Data sourced from SEC EDGAR 10-Q quarterly filings. Figures may represent quarterly or cumulative values.

Puma Biotechnology, Inc.. Dividends, Buybacks & Capital Allocation

Operating Cash Flow
$15.4M
Cash generated from operations
Stock Buybacks
$40.0K
Shares repurchased (TTM)
Dividends
None
No dividend program

PBYI SEC Filings: Latest 10-K & 10-Q Analysis

Access official SEC EDGAR filings for Puma Biotechnology, Inc.. (CIK: 0001401667)

📋 Recent SEC Filings

Date Form Document Action
May 7, 2026 10-Q pbyi20260331_10q.htm View →
May 7, 2026 8-K pbyi20260327_8k.htm View →
Apr 28, 2026 DEF 14A pbyi20260415_def14a.htm View →
Feb 26, 2026 10-K pbyi20251231_10k.htm View →
Feb 26, 2026 8-K pbyi20260204_8k.htm View →

Frequently Asked Questions about PBYI

What is the AI rating for PBYI?

Puma Biotechnology, Inc.. (PBYI) has an AI grade of C with 75% confidence, based on fundamental analysis of SEC EDGAR filings.

What are PBYI's key strengths?

Claude: Strong positive free cash flow of $15.4M with 34.4% FCF margin, providing operational cash generation despite net losses. Excellent liquidity position with current ratio of 2.38x and $36.2M in cash equivalents.

What are the risks of investing in PBYI?

Claude: Currently unprofitable with negative operating margin (-8.5%) and negative net income (-$3.8M); negative interest coverage (-1.1x) indicates inability to cover interest from operations. Revenue stagnation at -0.9% YoY decline with no visible growth momentum, highly concerning for pharmaceutical sector requiring expansion to offset R&D costs.

What is PBYI's revenue and growth?

Puma Biotechnology, Inc.. reported revenue of $44.8M.

Does PBYI pay dividends?

Puma Biotechnology, Inc.. does not currently pay dividends.

Where can I find PBYI SEC filings?

Official SEC filings for Puma Biotechnology, Inc.. (CIK: 0001401667) including 10-K, 10-Q, and 8-K reports are available on SEC EDGAR.

What is PBYI's EPS?

Puma Biotechnology, Inc.. has a diluted EPS of $-0.07.

How is the AI analysis conducted?

Two independent AI systems — Claude (Anthropic) and ChatGPT (OpenAI) — analyze SEC EDGAR filings including 10-K annual reports and 10-Q quarterly reports. Each AI evaluates financial health, profitability ratios, balance sheet strength, and growth metrics. The combined grade reflects both perspectives for balanced insights.

What is PBYI's fundamental grade?

Based on our AI fundamental analysis in June 2026, Puma Biotechnology, Inc.. has a C grade with 75% confidence. Review the strengths and risks sections above for full context. This is not investment advice.

Is PBYI stock overvalued or undervalued?

Valuation metrics for PBYI: ROE of -2.9% (sector avg: 15%), net margin of -8.4% (sector avg: 12%). Compare these metrics with sector averages to assess valuation.

What is PBYI's AI grade for 2026?

Our dual AI analysis gives Puma Biotechnology, Inc.. a combined C grade for 2026. Revenue is data pending, with profitability at or below sector average. Always conduct your own research.

What is PBYI's free cash flow?

Puma Biotechnology, Inc..'s operating cash flow is $15.4M, with capital expenditures of $0.0. FCF margin is 34.4%.

How does PBYI compare to other Healthcare stocks?

Vs Healthcare sector averages: Net margin -8.4% (avg: 12%), ROE -2.9% (avg: 15%), current ratio 2.38 (avg: 2).

Top Rated Stocks
AAPL 92% MSFT 92% FAST 92% ANET 88% RDDT 88% KNSL 88% MGRE 88% FIZZ 88% DECK 87% NVDA 87%
Sector: All Healthcare Stocks →
Disclaimer: This analysis is generated by Claude AI (Anthropic) and ChatGPT (OpenAI) based on publicly available SEC EDGAR filings. It does not include stock price data and should not be considered financial advice. All fundamental data is sourced from SEC public domain filings. Always conduct your own research and consult with a qualified financial advisor before making investment decisions.
Data Source: SEC EDGAR | Analysis Date: May 9, 2026 | Data as of: 2026-03-31 | Powered by Claude AI