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OnKure Therapeutics, Inc. (OKUR) Stock Fundamental Analysis & AI Rating 2026

OKUR Nasdaq Pharmaceutical Preparations DE CIK: 0001637715
Recently Updated • Analysis: Apr 13, 2026 • SEC Data: 2025-12-31
SELL
75% Conf
Pending
Analysis scheduled

📊 OKUR Key Takeaways

Revenue: $3.4M
Net Margin: -1,733.7%
Free Cash Flow: $-51.9M
Current Ratio: 10.28x
Debt/Equity: 0.00x
EPS: $-4.40
AI Rating: SELL with 75% confidence
OnKure Therapeutics, Inc. (OKUR) receives a SELL rating with 75% confidence from our AI fundamental analysis based on SEC 10-K filings. With revenue of $3.4M, net profit margin of -1,733.7%, and return on equity (ROE) of -105.9%, OnKure Therapeutics, Inc. demonstrates mixed fundamentals in the Healthcare sector. Below is our complete OKUR stock analysis for 2026.

Is OnKure Therapeutics, Inc. (OKUR) a Good Investment?

Claude

OnKure Therapeutics exhibits classic pre-commercial biotech fundamentals: minimal $3.4M revenue against a massive $63M operating loss, yielding an operating margin of -1833%. While the $59M cash position and zero debt provide near-term runway (~1.1 years at current burn), the company's sustainability depends entirely on unproven drug development success with no visible path to profitability. The 71% YoY EPS improvement signals reduced losses but remains far from breakeven.

Why Buy OnKure Therapeutics, Inc. Stock? OKUR Key Strengths

Claude
  • + Strong cash position ($59M) provides 12+ months operational runway
  • + Zero debt with healthy balance sheet ($56.2M equity vs $5.9M liabilities)
  • + Excellent liquidity (10.28x current ratio) reduces near-term solvency risk

OKUR Stock Risks: OnKure Therapeutics, Inc. Investment Risks

Claude
  • ! Unsustainable cash burn rate (-$51.8M annually) with only 1.1-year runway before capital raise likely required
  • ! Minimal revenue ($3.4M) against massive R&D spend indicates pre-commercialization stage with unproven drug candidates and significant execution risk
  • ! Severe margin profile (-1733.7% net margin) typical of biotech but requires successful clinical outcomes and regulatory approval for turnaround
  • ! High dilution risk if capital raise becomes necessary; pharma pipeline success rate inherently low

Key Metrics to Watch

Claude
  • * Cash burn trend and runway extension (any slowdown in operating cash outflow)
  • * Pipeline progress and clinical trial milestones (regulatory approvals or partnership announcements)
  • * Revenue growth rate upon product commercialization

OnKure Therapeutics, Inc. (OKUR) Financial Metrics & Key Ratios

Revenue
$3.4M
Net Income
$-59.5M
EPS (Diluted)
$-4.40
Free Cash Flow
$-51.9M
Total Assets
$62.1M
Cash Position
$59.1M

💡 AI Analyst Insight

Strong liquidity with a 10.28x current ratio provides a solid financial cushion.

OKUR Profit Margin, ROE & Profitability Analysis

Gross Margin N/A
Operating Margin -1,833.7%
Net Margin -1,733.7%
ROE -105.9%
ROA -95.8%
FCF Margin -1,511.0%

OKUR vs Healthcare Sector: How OnKure Therapeutics, Inc. Compares

How OnKure Therapeutics, Inc. compares to Healthcare sector averages

Net Margin
OKUR -1,733.7%
vs
Sector Avg 12.0%
OKUR Sector
ROE
OKUR -105.9%
vs
Sector Avg 15.0%
OKUR Sector
Current Ratio
OKUR 10.3x
vs
Sector Avg 2.0x
OKUR Sector
Debt/Equity
OKUR 0.0x
vs
Sector Avg 0.6x
OKUR Sector

Sector benchmarks are approximate industry averages. Actual sector performance may vary.

Is OnKure Therapeutics, Inc. Stock Overvalued? OKUR Valuation Analysis 2026

Based on fundamental analysis, OnKure Therapeutics, Inc. has mixed fundamental signals relative to the Healthcare sector in 2026.

Return on Equity
-105.9%
Sector avg: 15%
Net Profit Margin
-1,733.7%
Sector avg: 12%
Revenue Growth
N/A
Year-over-year
Debt/Equity
0.00x
Sector avg: 0.6x

Note: This is a fundamental analysis based on SEC filings. For P/E ratio, price targets, and market-based valuation, consult financial data providers. This is not investment advice.

OnKure Therapeutics, Inc. Balance Sheet: OKUR Debt, Cash & Liquidity

Current Ratio
10.28x
Quick Ratio
10.28x
Debt/Equity
0.00x
Debt/Assets
9.6%
Interest Coverage
N/A
Long-term Debt
N/A

OKUR Revenue & Earnings Growth: 5-Year Financial Trend

OKUR 5-year financial data: Year 2024: Revenue $0, Net Income -$35.3M, EPS $-124.41.
Revenue
Net Income
EPS (right axis)

5-Year Trend Summary: OnKure Therapeutics, Inc.'s revenue has remained relatively flat over the 5-year period, with a 0% decline. The most recent EPS of $-15.28 indicates the company is currently unprofitable.

OKUR Revenue Growth, EPS Growth & YoY Performance

Revenue Growth
N/A
Year-over-year
Net Income Growth
N/A
Year-over-year
EPS Growth
N/A
Earnings per share
FCF Margin
-1,511.0%
Free cash flow / Revenue

OnKure Therapeutics, Inc. Dividends, Buybacks & Capital Allocation

Operating Cash Flow
-$51.8M
Cash generated from operations
Stock Buybacks
$4.4M
Shares repurchased (TTM)
Capital Expenditures
$46.0K
Investment in assets
Dividends
None
No dividend program

OKUR SEC Filings: Latest 10-K & 10-Q Analysis

Access official SEC EDGAR filings for OnKure Therapeutics, Inc. (CIK: 0001637715)

📋 Recent SEC Filings

Date Form Document Action
Apr 3, 2026 4 xslF345X06/form4-04032026_070404.xml View →
Apr 3, 2026 4 xslF345X06/form4-04032026_070438.xml View →
Apr 3, 2026 4 xslF345X06/form4-04032026_070422.xml View →
Apr 3, 2026 4 xslF345X06/form4-04032026_070420.xml View →
Apr 1, 2026 4 xslF345X06/form4-04012026_090435.xml View →

Frequently Asked Questions about OKUR

What is the AI rating for OKUR?

OnKure Therapeutics, Inc. (OKUR) has an AI rating of SELL with 75% confidence, based on fundamental analysis of SEC EDGAR filings.

What are OKUR's key strengths?

Claude: Strong cash position ($59M) provides 12+ months operational runway. Zero debt with healthy balance sheet ($56.2M equity vs $5.9M liabilities).

What are the risks of investing in OKUR?

Claude: Unsustainable cash burn rate (-$51.8M annually) with only 1.1-year runway before capital raise likely required. Minimal revenue ($3.4M) against massive R&D spend indicates pre-commercialization stage with unproven drug candidates and significant execution risk.

What is OKUR's revenue and growth?

OnKure Therapeutics, Inc. reported revenue of $3.4M.

Does OKUR pay dividends?

OnKure Therapeutics, Inc. does not currently pay dividends.

Where can I find OKUR SEC filings?

Official SEC filings for OnKure Therapeutics, Inc. (CIK: 0001637715) including 10-K, 10-Q, and 8-K reports are available on SEC EDGAR.

What is OKUR's EPS?

OnKure Therapeutics, Inc. has a diluted EPS of $-4.40.

How is the AI analysis conducted?

Two independent AI systems — Claude (Anthropic) and ChatGPT (OpenAI) — analyze SEC EDGAR filings including 10-K annual reports and 10-Q quarterly reports. Each AI evaluates financial health, profitability ratios, balance sheet strength, and growth metrics. The combined rating reflects both perspectives for balanced insights.

Is OKUR a good stock to buy right now?

Based on our AI fundamental analysis in April 2026, OnKure Therapeutics, Inc. has a SELL rating with 75% confidence. Review the strengths and risks sections above before making a decision. This is not investment advice.

Is OKUR stock overvalued or undervalued?

Valuation metrics for OKUR: ROE of -105.9% (sector avg: 15%), net margin of -1,733.7% (sector avg: 12%). Compare these metrics with sector averages to assess valuation.

Should I buy OKUR stock in 2026?

Our dual AI analysis gives OnKure Therapeutics, Inc. a combined SELL rating for 2026. Revenue is data pending, with profitability at or below sector average. Always conduct your own research.

What is OKUR's free cash flow?

OnKure Therapeutics, Inc.'s operating cash flow is $-51.8M, with capital expenditures of $46.0K. FCF margin is -1,511.0%.

How does OKUR compare to other Healthcare stocks?

Vs Healthcare sector averages: Net margin -1,733.7% (avg: 12%), ROE -105.9% (avg: 15%), current ratio 10.28 (avg: 2).

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Disclaimer: This analysis is generated by Claude AI (Anthropic) and ChatGPT (OpenAI) based on publicly available SEC EDGAR filings. It does not include stock price data and should not be considered financial advice. All fundamental data is sourced from SEC public domain filings. Always conduct your own research and consult with a qualified financial advisor before making investment decisions.
Data Source: SEC EDGAR | Analysis Date: Apr 13, 2026 | Data as of: 2025-12-31 | Powered by Claude AI