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Krystal Biotech, Inc. (KRYS) Stock Fundamental Analysis & AI Rating 2026

KRYS Nasdaq Biological Products, (No Diagnostic Substances) CIK: 0001711279
Recently Updated • Analysis: May 6, 2026 • SEC Data: 2026-03-31
Combined AI Rating
BUY
82% Confidence
STRONG AGREEMENT
BUY
82% Conf
BUY
82% Conf

📊 KRYS Key Takeaways

Revenue: $116.4M
Net Margin: 48.1%
Free Cash Flow: $73.2M
Current Ratio: 9.46x
Debt/Equity: 0.00x
EPS: $1.83
AI Rating: BUY with 82% confidence
Krystal Biotech, Inc. (KRYS) receives a BUY rating with 82% confidence from our AI fundamental analysis based on SEC 10-K filings. With revenue of $116.4M, net profit margin of 48.1%, and return on equity (ROE) of 4.4%, Krystal Biotech, Inc. demonstrates strong fundamentals in the Healthcare sector. Below is our complete KRYS stock analysis for 2026.

Is Krystal Biotech, Inc. (KRYS) a Good Investment?

Claude

Krystal Biotech demonstrates exceptional fundamental strength with 48.1% net margins, 33.9% revenue growth, and explosive 129.7% net income growth driven by strong operating leverage. The company maintains a fortress balance sheet with $501.3M cash, minimal debt, and excellent free cash flow generation ($73.2M, 62.9% FCF margin), positioning it to weather biotech headwinds and fund long-term growth.

ChatGPT

Krystal Biotech shows standout fundamentals with 33.9% revenue growth, exceptional operating (41.5%) and net (52.6%) margins, strong ROE/ROA, and a 48.5% FCF margin. A cash-rich, near-debt-free balance sheet supports continued investment, with upside if revenue proves recurring rather than milestone-driven.

Why Buy Krystal Biotech, Inc. Stock? KRYS Key Strengths

Claude
  • + Exceptional profitability: 48.1% net margin and 46.1% operating margin indicate strong pricing power and cost control
  • + Outstanding cash generation: $73.2M free cash flow with 62.9% margin demonstrates revenue quality and sustainability
  • + Fortress balance sheet: $501.3M cash, only $4.3M debt, minimal financial risk with 9.46x current ratio
  • + Accelerating bottom-line growth: Net income growth (129.7% YoY) outpacing revenue growth (33.9%) shows operating leverage
  • + Low capex intensity: Only $7.1M capex needed relative to cash generation suggests efficient, asset-light model
ChatGPT
  • + Exceptional profitability and cash generation (operating margin 41.5%, FCF margin 48.5%).
  • + Robust liquidity and minimal leverage (current ratio 9.95x; negligible debt).
  • + Healthy returns on capital (ROE 16.8%, ROA 15.4%).

KRYS Stock Risks: Krystal Biotech, Inc. Investment Risks

Claude
  • ! Capital efficiency concerns: ROE of 4.4% and ROA of 4.0% despite strong profitability suggests underdeployed capital and excess cash accumulation
  • ! Biotech-specific risks: Regulatory approval uncertainties, product pipeline execution, and potential competitive threats inherent to sector
  • ! Margin sustainability risk: 48.1% net margin may not be sustainable if product mix shifts or competitive pressures increase
  • ! Incomplete profitability visibility: Gross margin data unavailable prevents full assessment of product-level profitability
  • ! Growth deceleration potential: Whether 33.9% revenue growth can be sustained remains uncertain; net income growth appears non-linear
ChatGPT
  • ! Revenue durability and concentration risk typical of early commercial biotechs.
  • ! Potential non-recurring or milestone revenue inflating margins (gross margin N/A).
  • ! Pricing/reimbursement and regulatory/manufacturing execution could pressure growth.

Key Metrics to Watch

Claude
  • * Gross margin trends and product-level profitability
  • * Quarterly revenue growth sustainability and any signs of deceleration
  • * Operating cash flow consistency and working capital management
  • * Strategic deployment or capital allocation of accumulated $501.3M cash reserve
  • * Regulatory approval progress and product pipeline advancement
ChatGPT
  • * Revenue mix: recurring product vs one-time/milestone.
  • * Operating margin sustainability (target >=35%).

Krystal Biotech, Inc. (KRYS) Financial Metrics & Key Ratios

Revenue
$116.4M
Net Income
$55.9M
EPS (Diluted)
$1.83
Free Cash Flow
$73.2M
Total Assets
$1.4B
Cash Position
$501.3M

💡 AI Analyst Insight

The 62.9% free cash flow margin provides substantial flexibility for dividends, buybacks, and strategic investments. Strong liquidity with a 9.46x current ratio provides a solid financial cushion.

KRYS Profit Margin, ROE & Profitability Analysis

Gross Margin N/A
Operating Margin 46.1%
Net Margin 48.1%
ROE 4.4%
ROA 4.0%
FCF Margin 62.9%

KRYS vs Healthcare Sector: How Krystal Biotech, Inc. Compares

How Krystal Biotech, Inc. compares to Healthcare sector averages

Net Margin
KRYS 48.1%
vs
Sector Avg 12.0%
KRYS Sector
ROE
KRYS 4.4%
vs
Sector Avg 15.0%
KRYS Sector
Current Ratio
KRYS 9.5x
vs
Sector Avg 2.0x
KRYS Sector
Debt/Equity
KRYS 0.0x
vs
Sector Avg 0.6x
KRYS Sector

Sector benchmarks are approximate industry averages. Actual sector performance may vary.

Is Krystal Biotech, Inc. Stock Overvalued? KRYS Valuation Analysis 2026

Based on fundamental analysis, Krystal Biotech, Inc. has mixed fundamental signals relative to the Healthcare sector in 2026.

Return on Equity
4.4%
Sector avg: 15%
Net Profit Margin
48.1%
Sector avg: 12%
Revenue Growth
N/A
Year-over-year
Debt/Equity
0.00x
Sector avg: 0.6x

Note: This is a fundamental analysis based on SEC filings. For P/E ratio, price targets, and market-based valuation, consult financial data providers. This is not investment advice.

Krystal Biotech, Inc. Balance Sheet: KRYS Debt, Cash & Liquidity

Current Ratio
9.46x
Quick Ratio
9.06x
Debt/Equity
0.00x
Debt/Assets
8.6%
Interest Coverage
N/A
Long-term Debt
$4.3M

KRYS Revenue & Earnings Growth: 5-Year Financial Trend

KRYS 5-year financial data: Year 2023: Revenue $50.7M, Net Income -$69.6M, EPS $-3.13. Year 2024: Revenue $290.5M, Net Income -$140.0M, EPS $-5.49. Year 2025: Revenue $389.1M, Net Income $10.9M, EPS $0.39.
Revenue
Net Income
EPS (right axis)

5-Year Trend Summary: Krystal Biotech, Inc.'s revenue has grown significantly by 668% over the 5-year period, indicating strong business expansion. The most recent EPS of $0.39 reflects profitable operations.

KRYS Revenue Growth, EPS Growth & YoY Performance

Revenue Growth
N/A
Year-over-year
Net Income Growth
N/A
Year-over-year
EPS Growth
N/A
Earnings per share
FCF Margin
62.9%
Free cash flow / Revenue

KRYS Quarterly Earnings & Performance

Quarterly financial performance data for Krystal Biotech, Inc. including revenue, net income, and earnings per share.
Quarter Revenue Net Income EPS
Q1 2026 $88.2M $35.7M $1.20
Q3 2025 $83.8M $932.0K $0.91
Q2 2025 $70.3M $932.0K $0.53
Q1 2025 $45.3M $932.0K $0.03
Q3 2024 $8.6M $932.0K $0.08
Q2 2024 N/A $932.0K $0.53
Q1 2024 N/A $932.0K $0.03
Q3 2023 N/A $2.2M $0.08

Data sourced from SEC EDGAR 10-Q quarterly filings. Figures may represent quarterly or cumulative values.

Krystal Biotech, Inc. Dividends, Buybacks & Capital Allocation

Operating Cash Flow
$80.4M
Cash generated from operations
Capital Expenditures
$7.1M
Investment in assets
Dividends
None
No dividend program

KRYS SEC Filings: Latest 10-K & 10-Q Analysis

Access official SEC EDGAR filings for Krystal Biotech, Inc. (CIK: 0001711279)

📋 Recent SEC Filings

Date Form Document Action
May 4, 2026 8-K krys-20260504.htm View →
May 4, 2026 10-Q krys-20260331.htm View →
Apr 3, 2026 DEF 14A krys-20260403.htm View →
Mar 6, 2026 4 xslF345X05/wk-form4_1772839386.xml View →
Mar 6, 2026 4 xslF345X05/wk-form4_1772839326.xml View →

Frequently Asked Questions about KRYS

What is the AI rating for KRYS?

Krystal Biotech, Inc. (KRYS) has a Combined AI Rating of BUY from Claude (BUY) and ChatGPT (BUY) with 82% combined confidence, based on fundamental analysis of SEC EDGAR filings.

What are KRYS's key strengths?

Claude: Exceptional profitability: 48.1% net margin and 46.1% operating margin indicate strong pricing power and cost control. Outstanding cash generation: $73.2M free cash flow with 62.9% margin demonstrates revenue quality and sustainability. ChatGPT: Exceptional profitability and cash generation (operating margin 41.5%, FCF margin 48.5%).. Robust liquidity and minimal leverage (current ratio 9.95x; negligible debt)..

What are the risks of investing in KRYS?

Claude: Capital efficiency concerns: ROE of 4.4% and ROA of 4.0% despite strong profitability suggests underdeployed capital and excess cash accumulation. Biotech-specific risks: Regulatory approval uncertainties, product pipeline execution, and potential competitive threats inherent to sector. ChatGPT: Revenue durability and concentration risk typical of early commercial biotechs.. Potential non-recurring or milestone revenue inflating margins (gross margin N/A)..

What is KRYS's revenue and growth?

Krystal Biotech, Inc. reported revenue of $116.4M.

Does KRYS pay dividends?

Krystal Biotech, Inc. does not currently pay dividends.

Where can I find KRYS SEC filings?

Official SEC filings for Krystal Biotech, Inc. (CIK: 0001711279) including 10-K, 10-Q, and 8-K reports are available on SEC EDGAR.

What is KRYS's EPS?

Krystal Biotech, Inc. has a diluted EPS of $1.83.

How is the AI analysis conducted?

Two independent AI systems — Claude (Anthropic) and ChatGPT (OpenAI) — analyze SEC EDGAR filings including 10-K annual reports and 10-Q quarterly reports. Each AI evaluates financial health, profitability ratios, balance sheet strength, and growth metrics. The combined rating reflects both perspectives for balanced insights.

Is KRYS a good stock to buy right now?

Based on our AI fundamental analysis in May 2026, Krystal Biotech, Inc. has a BUY rating with 82% confidence. The AI analysis suggests favorable fundamentals based on SEC filings. This is not investment advice.

Is KRYS stock overvalued or undervalued?

Valuation metrics for KRYS: ROE of 4.4% (sector avg: 15%), net margin of 48.1% (sector avg: 12%). Compare these metrics with sector averages to assess valuation.

Should I buy KRYS stock in 2026?

Our dual AI analysis gives Krystal Biotech, Inc. a combined BUY rating for 2026. Revenue is data pending, with profitability above sector average. Always conduct your own research.

What is KRYS's free cash flow?

Krystal Biotech, Inc.'s operating cash flow is $80.4M, with capital expenditures of $7.1M. FCF margin is 62.9%.

How does KRYS compare to other Healthcare stocks?

Vs Healthcare sector averages: Net margin 48.1% (avg: 12%), ROE 4.4% (avg: 15%), current ratio 9.46 (avg: 2).

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Disclaimer: This analysis is generated by Claude AI (Anthropic) and ChatGPT (OpenAI) based on publicly available SEC EDGAR filings. It does not include stock price data and should not be considered financial advice. All fundamental data is sourced from SEC public domain filings. Always conduct your own research and consult with a qualified financial advisor before making investment decisions.
Data Source: SEC EDGAR | Analysis Date: May 6, 2026 | Data as of: 2026-03-31 | Powered by Claude AI