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Fulcrum Therapeutics, Inc. (FULC) Stock Fundamental Analysis & AI Rating 2026

FULC Nasdaq Pharmaceutical Preparations DE CIK: 0001680581
Updated This Month • Analysis: Apr 29, 2026 • SEC Data: 2026-03-31
Combined AI Rating
SELL
80% Confidence
STRONG AGREEMENT
SELL
78% Conf
SELL
81% Conf

📊 FULC Key Takeaways

Revenue: $0.0
Net Margin: N/A
Free Cash Flow: $-18.8M
Current Ratio: 34.33x
Debt/Equity: 0.00x
EPS: $-0.25
AI Rating: SELL with 78% confidence
Fulcrum Therapeutics, Inc. (FULC) receives a SELL rating with 80% confidence from our AI fundamental analysis based on SEC 10-K filings. With revenue of $0, and return on equity (ROE) of -5.7%, Fulcrum Therapeutics, Inc. demonstrates mixed fundamentals in the Healthcare sector. Below is our complete FULC stock analysis for 2026.

Is Fulcrum Therapeutics, Inc. (FULC) a Good Investment?

Claude

Fulcrum Therapeutics is a pre-revenue, clinical-stage pharmaceutical company burning $18.8M annually with zero commercialized products. While the balance sheet remains strong with $50.3M cash and zero debt, the current burn rate provides only ~2.7 years of runway absent new financing or revenue generation. The company faces typical biotech development risks with substantial uncertainty around clinical trial success and regulatory approval timelines.

ChatGPT

Fulcrum Therapeutics shows very weak operating fundamentals: revenue fell to zero, operating losses remain large, and free cash flow is deeply negative. The balance sheet is unusually strong for a development-stage biotech, with substantial cash, no meaningful debt, and very high liquidity, but absent a clear revenue base or improving loss trajectory, the business currently relies on cash runway and pipeline execution rather than durable operating strength.

Why Buy Fulcrum Therapeutics, Inc. Stock? FULC Key Strengths

Claude
  • + Debt-free balance sheet with zero long-term debt and minimal liabilities ($13.5M)
  • + Substantial cash reserves ($50.3M) and strong liquidity (34.33x current ratio) providing near-term operational flexibility
  • + Healthy stockholders' equity of $333.3M representing solid capital base relative to asset base
ChatGPT
  • + Strong balance sheet with $197.53M of cash and $349.00M of equity against only $17.28M of liabilities
  • + No meaningful leverage, with debt/equity at 0.00x, reducing financial distress risk
  • + Very high liquidity, with current and quick ratios of 27.40x, supporting near-term funding needs

FULC Stock Risks: Fulcrum Therapeutics, Inc. Investment Risks

Claude
  • ! Zero revenue indicates no approved, commercialized products; company remains in clinical development stage
  • ! Negative operating cash flow of $18.8M annually with no clear path to profitability without successful product commercialization
  • ! Limited cash runway (~2.7 years at current burn rate) creating near-term financing dependency and dilution risk for existing shareholders
  • ! Typical biotech/pharma risks: clinical trial failures, regulatory rejection, and extended development timelines
ChatGPT
  • ! Revenue collapsed to $0.00, indicating no current commercial or collaboration income support
  • ! Large ongoing losses, including -$84.77M operating income and -$60.38M free cash flow, show continued cash consumption
  • ! Growth quality is weak because the business is not yet self-funding and future performance is highly dependent on pipeline and execution outcomes

Key Metrics to Watch

Claude
  • * Cash burn rate and cash runway remaining before additional financing required
  • * Clinical trial progress and FDA milestone achievements for pipeline candidates
  • * Revenue timing for first commercialized product and clinical pipeline advancement
ChatGPT
  • * Quarterly operating cash flow and cash burn relative to cash balance
  • * Any return of recurring revenue and the trend in operating loss

Fulcrum Therapeutics, Inc. (FULC) Financial Metrics & Key Ratios

Revenue
$0.0
Net Income
$-18.9M
EPS (Diluted)
$-0.25
Free Cash Flow
$-18.8M
Total Assets
$346.8M
Cash Position
$50.3M

💡 AI Analyst Insight

Strong liquidity with a 34.33x current ratio provides a solid financial cushion.

FULC Profit Margin, ROE & Profitability Analysis

Gross Margin N/A
Operating Margin N/A
Net Margin N/A
ROE -5.7%
ROA -5.4%
FCF Margin N/A

FULC vs Healthcare Sector: How Fulcrum Therapeutics, Inc. Compares

How Fulcrum Therapeutics, Inc. compares to Healthcare sector averages

Net Margin
FULC 0.0%
vs
Sector Avg 12.0%
FULC Sector
ROE
FULC -5.7%
vs
Sector Avg 15.0%
FULC Sector
Current Ratio
FULC 34.3x
vs
Sector Avg 2.0x
FULC Sector
Debt/Equity
FULC 0.0x
vs
Sector Avg 0.6x
FULC Sector

Sector benchmarks are approximate industry averages. Actual sector performance may vary.

Is Fulcrum Therapeutics, Inc. Stock Overvalued? FULC Valuation Analysis 2026

Based on fundamental analysis, Fulcrum Therapeutics, Inc. has mixed fundamental signals relative to the Healthcare sector in 2026.

Return on Equity
-5.7%
Sector avg: 15%
Net Profit Margin
N/A
Sector avg: 12%
Revenue Growth
N/A
Year-over-year
Debt/Equity
0.00x
Sector avg: 0.6x

Note: This is a fundamental analysis based on SEC filings. For P/E ratio, price targets, and market-based valuation, consult financial data providers. This is not investment advice.

Fulcrum Therapeutics, Inc. Balance Sheet: FULC Debt, Cash & Liquidity

Current Ratio
34.33x
Quick Ratio
34.33x
Debt/Equity
0.00x
Debt/Assets
3.9%
Interest Coverage
N/A
Long-term Debt
N/A

FULC Revenue & Earnings Growth: 5-Year Financial Trend

FULC 5-year financial data: Year 2021: Revenue $19.2M, Net Income -$70.8M, EPS N/A. Year 2022: Revenue $19.2M, Net Income -$80.8M, EPS $-2.29. Year 2023: Revenue $6.3M, Net Income -$109.9M, EPS $-2.44. Year 2024: Revenue $80.0M, Net Income -$97.3M, EPS $-1.59. Year 2025: Revenue $80.0M, Net Income -$9.7M, EPS $-0.16.
Revenue
Net Income
EPS (right axis)

5-Year Trend Summary: Fulcrum Therapeutics, Inc.'s revenue has grown significantly by 317% over the 5-year period, indicating strong business expansion. The most recent EPS of $-0.16 indicates the company is currently unprofitable.

FULC Revenue Growth, EPS Growth & YoY Performance

Revenue Growth
N/A
Year-over-year
Net Income Growth
N/A
Year-over-year
EPS Growth
N/A
Earnings per share
FCF Margin
N/A
Free cash flow / Revenue

FULC Quarterly Earnings & Performance

Quarterly financial performance data for Fulcrum Therapeutics, Inc. including revenue, net income, and earnings per share.
Quarter Revenue Net Income EPS
Q3 2025 N/A $6.8M $0.11
Q2 2025 N/A -$17.3M $-0.28
Q3 2024 N/A $6.8M $0.11
Q2 2024 $880.0K -$23.8M $-0.38
Q1 2024 N/A -$24.8M $-0.41
Q3 2023 $759.0K -$23.7M $-0.39
Q1 2023 $295.0K -$23.8M $-0.38
Q3 2022 $1.2M -$17.0M $-0.51

Data sourced from SEC EDGAR 10-Q quarterly filings. Figures may represent quarterly or cumulative values.

Fulcrum Therapeutics, Inc. Dividends, Buybacks & Capital Allocation

Operating Cash Flow
-$18.8M
Cash generated from operations
Capital Expenditures
$8.0K
Investment in assets
Dividends
None
No dividend program

FULC SEC Filings: Latest 10-K & 10-Q Analysis

Access official SEC EDGAR filings for Fulcrum Therapeutics, Inc. (CIK: 0001680581)

📋 Recent SEC Filings

Date Form Document Action
May 1, 2026 4 xslF345X06/ownership.xml View →
Apr 30, 2026 DEF 14A fulc-20260430.htm View →
Apr 27, 2026 10-Q fulc-20260331.htm View →
Apr 27, 2026 8-K fulc-20260423.htm View →
Feb 24, 2026 10-K fulc-20251231.htm View →

Frequently Asked Questions about FULC

What is the AI rating for FULC?

Fulcrum Therapeutics, Inc. (FULC) has a Combined AI Rating of SELL from Claude (SELL) and ChatGPT (SELL) with 80% combined confidence, based on fundamental analysis of SEC EDGAR filings.

What are FULC's key strengths?

Claude: Debt-free balance sheet with zero long-term debt and minimal liabilities ($13.5M). Substantial cash reserves ($50.3M) and strong liquidity (34.33x current ratio) providing near-term operational flexibility. ChatGPT: Strong balance sheet with $197.53M of cash and $349.00M of equity against only $17.28M of liabilities. No meaningful leverage, with debt/equity at 0.00x, reducing financial distress risk.

What are the risks of investing in FULC?

Claude: Zero revenue indicates no approved, commercialized products; company remains in clinical development stage. Negative operating cash flow of $18.8M annually with no clear path to profitability without successful product commercialization. ChatGPT: Revenue collapsed to $0.00, indicating no current commercial or collaboration income support. Large ongoing losses, including -$84.77M operating income and -$60.38M free cash flow, show continued cash consumption.

What is FULC's revenue and growth?

Fulcrum Therapeutics, Inc. reported revenue of $0.0.

Does FULC pay dividends?

Fulcrum Therapeutics, Inc. does not currently pay dividends.

Where can I find FULC SEC filings?

Official SEC filings for Fulcrum Therapeutics, Inc. (CIK: 0001680581) including 10-K, 10-Q, and 8-K reports are available on SEC EDGAR.

What is FULC's EPS?

Fulcrum Therapeutics, Inc. has a diluted EPS of $-0.25.

How is the AI analysis conducted?

Two independent AI systems — Claude (Anthropic) and ChatGPT (OpenAI) — analyze SEC EDGAR filings including 10-K annual reports and 10-Q quarterly reports. Each AI evaluates financial health, profitability ratios, balance sheet strength, and growth metrics. The combined rating reflects both perspectives for balanced insights.

Is FULC a good stock to buy right now?

Based on our AI fundamental analysis in May 2026, Fulcrum Therapeutics, Inc. has a SELL rating with 80% confidence. Review the strengths and risks sections above before making a decision. This is not investment advice.

Is FULC stock overvalued or undervalued?

Valuation metrics for FULC: ROE of -5.7% (sector avg: 15%), net margin of N/A (sector avg: 12%). Compare these metrics with sector averages to assess valuation.

Should I buy FULC stock in 2026?

Our dual AI analysis gives Fulcrum Therapeutics, Inc. a combined SELL rating for 2026. Revenue is data pending, with profitability at or below sector average. Always conduct your own research.

What is FULC's free cash flow?

Fulcrum Therapeutics, Inc.'s operating cash flow is $-18.8M, with capital expenditures of $8.0K.

How does FULC compare to other Healthcare stocks?

Vs Healthcare sector averages: Net margin N/A (avg: 12%), ROE -5.7% (avg: 15%), current ratio 34.33 (avg: 2).

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Disclaimer: This analysis is generated by Claude AI (Anthropic) and ChatGPT (OpenAI) based on publicly available SEC EDGAR filings. It does not include stock price data and should not be considered financial advice. All fundamental data is sourced from SEC public domain filings. Always conduct your own research and consult with a qualified financial advisor before making investment decisions.
Data Source: SEC EDGAR | Analysis Date: Apr 29, 2026 | Data as of: 2026-03-31 | Powered by Claude AI