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FULC Stock Analysis 2026 - Fulcrum Therapeutics, Inc. AI Rating

FULC Nasdaq Pharmaceutical Preparations DE CIK: 0001680581
Recently Updated • Analysis: Mar 25, 2026 • SEC Data: 2025-12-31
STRONG SELL
92% Conf
Pending
Analysis scheduled

📊 FULC Key Takeaways

Revenue: $0.0
Net Margin: N/A
Free Cash Flow: $-60.4M
Current Ratio: 27.40x
Debt/Equity: 0.00x
EPS: $-1.18
AI Rating: STRONG SELL with 92% confidence

Is FULC a Good Investment? Thesis Analysis

Claude

Fulcrum Therapeutics is a pre-revenue biopharmaceutical company with severe cash burn and no commercial revenue, indicating it has not successfully brought any products to market. With annual operating losses of $84.8M and free cash flow of -$60.4M, the company is in a critical runway phase despite maintaining $197.5M in cash reserves. The complete absence of revenue combined with substantial operating losses demonstrates the company faces significant execution risk in bringing pipeline programs to commercialization.

Why Buy FULC? Key Strengths

Claude
  • + Strong cash position of $197.5M provides runway for R&D operations
  • + No long-term debt obligations reduces financial leverage risk
  • + Excellent liquidity position with 27.4x current ratio ensures near-term solvency
  • + Significant stockholders equity of $349M provides balance sheet cushion

FULC Investment Risks to Consider

Claude
  • ! Zero revenue with $84.8M annual operating losses indicates no approved commercial products
  • ! Negative free cash flow of $60.4M annually means cash reserves deplete rapidly
  • ! Diluted EPS of -$1.18 with extreme YoY deterioration shows persistent losses
  • ! Pre-revenue status means company has not demonstrated ability to commercialize any assets
  • ! Current cash burn rate suggests approximately 3.3 years of runway before cash depletion
  • ! ROE of -21.5% and ROA of -20.4% indicate significant shareholder value destruction

Key Metrics to Watch

Claude
  • * Time to next major clinical milestone or regulatory approval
  • * Monthly cash burn rate trends and updated runway estimates
  • * Pipeline program advancement and clinical trial progress updates
  • * Quarterly revenue generation from any approved products

FULC Financial Metrics

Revenue
$0.0
Net Income
$-74.9M
EPS (Diluted)
$-1.18
Free Cash Flow
$-60.4M
Total Assets
$366.3M
Cash Position
$197.5M

💡 AI Analyst Insight

Strong liquidity with a 27.40x current ratio provides a solid financial cushion.

FULC Profitability Ratios

Gross Margin N/A
Operating Margin N/A
Net Margin N/A
ROE -21.5%
ROA -20.4%
FCF Margin N/A

FULC vs Healthcare Sector

How Fulcrum Therapeutics, Inc. compares to Healthcare sector averages

Net Margin
FULC 0.0%
vs
Sector Avg 12.0%
FULC Sector
ROE
FULC -21.5%
vs
Sector Avg 15.0%
FULC Sector
Current Ratio
FULC 27.4x
vs
Sector Avg 2.0x
FULC Sector
Debt/Equity
FULC 0.0x
vs
Sector Avg 0.6x
FULC Sector

Sector benchmarks are approximate industry averages. Actual sector performance may vary.

Is FULC Overvalued or Undervalued?

Based on fundamental analysis, Fulcrum Therapeutics, Inc. has mixed fundamental signals relative to the Healthcare sector in 2026.

Return on Equity
-21.5%
Sector avg: 15%
Net Profit Margin
N/A
Sector avg: 12%
Revenue Growth
N/A
Year-over-year
Debt/Equity
0.00x
Sector avg: 0.6x

Note: This is a fundamental analysis based on SEC filings. For P/E ratio, price targets, and market-based valuation, consult financial data providers. This is not investment advice.

FULC Balance Sheet & Liquidity

Current Ratio
27.40x
Quick Ratio
27.40x
Debt/Equity
0.00x
Debt/Assets
4.7%
Interest Coverage
N/A
Long-term Debt
N/A

FULC 5-Year Financial Trend & Growth Analysis

FULC 5-year financial data: Year 2021: Revenue $19.2M, Net Income -$70.8M, EPS N/A. Year 2022: Revenue $19.2M, Net Income -$80.8M, EPS $-2.29. Year 2023: Revenue $6.3M, Net Income -$109.9M, EPS $-2.44. Year 2024: Revenue $80.0M, Net Income -$97.3M, EPS $-1.59. Year 2025: Revenue $80.0M, Net Income -$9.7M, EPS $-0.16.
Revenue
Net Income
EPS (right axis)

5-Year Trend Summary: Fulcrum Therapeutics, Inc.'s revenue has grown significantly by 317% over the 5-year period, indicating strong business expansion. The most recent EPS of $-0.16 indicates the company is currently unprofitable.

FULC Growth Metrics (YoY)

Revenue Growth
N/A
Year-over-year
Net Income Growth
N/A
Year-over-year
EPS Growth
N/A
Earnings per share
FCF Margin
N/A
Free cash flow / Revenue

FULC Quarterly Performance

Quarterly financial performance data for Fulcrum Therapeutics, Inc. including revenue, net income, and earnings per share.
Quarter Revenue Net Income EPS
Q3 2025 N/A $6.8M $0.11
Q2 2025 N/A -$17.3M $-0.28
Q3 2024 N/A $6.8M $0.11
Q2 2024 $880.0K -$23.8M $-0.38
Q1 2024 N/A -$24.8M $-0.41
Q3 2023 $759.0K -$23.7M $-0.39
Q1 2023 $295.0K -$23.8M $-0.38
Q3 2022 $1.2M -$17.0M $-0.51

Data sourced from SEC EDGAR 10-Q quarterly filings. Figures may represent quarterly or cumulative values.

FULC Capital Allocation

Operating Cash Flow
-$60.1M
Cash generated from operations
Capital Expenditures
$314.0K
Investment in assets
Dividends
None
No dividend program

FULC SEC 10-K & 10-Q Filing Analysis

Access official SEC EDGAR filings for Fulcrum Therapeutics, Inc. (CIK: 0001680581)

📋 Recent SEC Filings

Date Form Document Action
Feb 24, 2026 10-K fulc-20251231.htm View →
Feb 24, 2026 8-K fulc-20260224.htm View →
Feb 4, 2026 4 xslF345X05/ownership.xml View →
Feb 4, 2026 4 xslF345X05/ownership.xml View →
Feb 4, 2026 4 xslF345X05/ownership.xml View →

Frequently Asked Questions about FULC

What is the AI rating for FULC?

Fulcrum Therapeutics, Inc. (FULC) has an AI rating of STRONG SELL with 92% confidence, based on fundamental analysis of SEC EDGAR filings.

What are FULC's key strengths?

Claude: Strong cash position of $197.5M provides runway for R&D operations. No long-term debt obligations reduces financial leverage risk.

What are the risks of investing in FULC?

Claude: Zero revenue with $84.8M annual operating losses indicates no approved commercial products. Negative free cash flow of $60.4M annually means cash reserves deplete rapidly.

What is FULC's revenue and growth?

Fulcrum Therapeutics, Inc. reported revenue of $0.0.

Does FULC pay dividends?

Fulcrum Therapeutics, Inc. does not currently pay dividends.

Where can I find FULC SEC filings?

Official SEC filings for Fulcrum Therapeutics, Inc. (CIK: 0001680581) including 10-K, 10-Q, and 8-K reports are available on SEC EDGAR.

What is FULC's EPS?

Fulcrum Therapeutics, Inc. has a diluted EPS of $-1.18.

How is the AI analysis conducted?

Two independent AI systems — Claude (Anthropic) and ChatGPT (OpenAI) — analyze SEC EDGAR filings including 10-K annual reports and 10-Q quarterly reports. Each AI evaluates financial health, profitability ratios, balance sheet strength, and growth metrics. The combined rating reflects both perspectives for balanced insights.

Is FULC a good stock to buy right now?

Based on our AI fundamental analysis in March 2026, Fulcrum Therapeutics, Inc. has a STRONG SELL rating with 92% confidence. Review the strengths and risks sections above before making a decision. This is not investment advice.

Is FULC stock overvalued or undervalued?

Valuation metrics for FULC: ROE of -21.5% (sector avg: 15%), net margin of N/A (sector avg: 12%). Compare these metrics with sector averages to assess valuation.

Should I buy FULC stock in 2026?

Our dual AI analysis gives Fulcrum Therapeutics, Inc. a combined STRONG SELL rating for 2026. Revenue is data pending, with profitability at or below sector average. Always conduct your own research.

What is FULC's free cash flow?

Fulcrum Therapeutics, Inc.'s operating cash flow is $-60.1M, with capital expenditures of $314.0K.

How does FULC compare to other Healthcare stocks?

Vs Healthcare sector averages: Net margin N/A (avg: 12%), ROE -21.5% (avg: 15%), current ratio 27.40 (avg: 2).

Disclaimer: This analysis is generated by Claude AI (Anthropic) and ChatGPT (OpenAI) based on publicly available SEC EDGAR filings. It does not include stock price data and should not be considered financial advice. All fundamental data is sourced from SEC public domain filings. Always conduct your own research and consult with a qualified financial advisor before making investment decisions.
Data Source: SEC EDGAR | Analysis Date: Mar 25, 2026 | Data as of: 2025-12-31 | Powered by Claude AI