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Taysha Gene Therapies, Inc. (TSHA) Stock Fundamental Analysis & AI Rating 2026

TSHA Nasdaq Biological Products, (No Diagnostic Substances) DE CIK: 0001806310
Recently Updated • Analysis: Apr 17, 2026 • SEC Data: 2025-12-31
SELL
72% Conf
Pending
Analysis scheduled

📊 TSHA Key Takeaways

Revenue: $9.8M
Net Margin: -1,115.3%
Free Cash Flow: $-93.8M
Current Ratio: 12.23x
Debt/Equity: 0.20x
EPS: $-0.34
AI Rating: SELL with 72% confidence
Taysha Gene Therapies, Inc. (TSHA) receives a SELL rating with 72% confidence from our AI fundamental analysis based on SEC 10-K filings. With revenue of $9.8M, net profit margin of -1,115.3%, and return on equity (ROE) of -44.1%, Taysha Gene Therapies, Inc. demonstrates mixed fundamentals in the Healthcare sector. Below is our complete TSHA stock analysis for 2026.

Is Taysha Gene Therapies, Inc. (TSHA) a Good Investment?

Claude

Taysha Gene Therapies exhibits severe operating losses (-$110.5M) on minimal revenue ($9.8M), burning $93.8M annually in free cash flow with limited runway despite a strong cash position of $319.8M. While early-stage biotech inherently operates at losses, the company's current trajectory shows no visible path to profitability and faces potential dilutive financing risk within 3-4 years at current burn rates.

Why Buy Taysha Gene Therapies, Inc. Stock? TSHA Key Strengths

Claude
  • + Strong balance sheet with $319.8M cash providing 3+ years operational runway
  • + Low leverage (Debt/Equity 0.20x) and minimal debt burden of $50.1M
  • + Revenue growth of +17.3% YoY demonstrates product traction and market demand
  • + Excellent liquidity (Current Ratio 12.23x) reduces financial distress risk
  • + Insider activity (5 Form 4 filings in 90 days) suggests management confidence

TSHA Stock Risks: Taysha Gene Therapies, Inc. Investment Risks

Claude
  • ! Extreme operating losses (-$110.5M) and negative operating margin (-1130.6%) unsustainable long-term
  • ! Annual free cash burn of $93.8M will exhaust cash reserves in 3.4 years without profitability inflection
  • ! Revenue scale ($9.8M) is negligible relative to operating expenses, indicating early-stage commercialization challenges
  • ! No gross profit visibility suggests weak unit economics or undisclosed cost structure
  • ! Gene therapy development risk includes clinical trial failures, regulatory hurdles, and manufacturing scale-up challenges

Key Metrics to Watch

Claude
  • * Operating Cash Flow trend and path to cash flow breakeven
  • * Revenue growth rate acceleration (currently +17.3%) relative to expense management
  • * Cash runway depletion rate and timeline to next financing event
  • * Product pipeline advancement and clinical trial success rates
  • * Gross margin realization once manufacturing scales

Taysha Gene Therapies, Inc. (TSHA) Financial Metrics & Key Ratios

Revenue
$9.8M
Net Income
$-109.0M
EPS (Diluted)
$-0.34
Free Cash Flow
$-93.8M
Total Assets
$343.3M
Cash Position
$319.8M

💡 AI Analyst Insight

Strong liquidity with a 12.23x current ratio provides a solid financial cushion.

TSHA Profit Margin, ROE & Profitability Analysis

Gross Margin N/A
Operating Margin -1,130.6%
Net Margin -1,115.3%
ROE -44.1%
ROA -31.7%
FCF Margin -960.1%

TSHA vs Healthcare Sector: How Taysha Gene Therapies, Inc. Compares

How Taysha Gene Therapies, Inc. compares to Healthcare sector averages

Net Margin
TSHA -1,115.3%
vs
Sector Avg 12.0%
TSHA Sector
ROE
TSHA -44.1%
vs
Sector Avg 15.0%
TSHA Sector
Current Ratio
TSHA 12.2x
vs
Sector Avg 2.0x
TSHA Sector
Debt/Equity
TSHA 0.2x
vs
Sector Avg 0.6x
TSHA Sector

Sector benchmarks are approximate industry averages. Actual sector performance may vary.

Is Taysha Gene Therapies, Inc. Stock Overvalued? TSHA Valuation Analysis 2026

Based on fundamental analysis, Taysha Gene Therapies, Inc. has mixed fundamental signals relative to the Healthcare sector in 2026.

Return on Equity
-44.1%
Sector avg: 15%
Net Profit Margin
-1,115.3%
Sector avg: 12%
Revenue Growth
N/A
Year-over-year
Debt/Equity
0.20x
Sector avg: 0.6x

Note: This is a fundamental analysis based on SEC filings. For P/E ratio, price targets, and market-based valuation, consult financial data providers. This is not investment advice.

Taysha Gene Therapies, Inc. Balance Sheet: TSHA Debt, Cash & Liquidity

Current Ratio
12.23x
Quick Ratio
12.23x
Debt/Equity
0.20x
Debt/Assets
28.1%
Interest Coverage
-1,973.18x
Long-term Debt
$50.1M

TSHA Revenue & Earnings Growth: 5-Year Financial Trend

TSHA 5-year financial data: Year 2022: Revenue $2.5M, Net Income -$174.5M, EPS $-4.64. Year 2023: Revenue $15.5M, Net Income -$166.0M, EPS $-3.78. Year 2024: Revenue $15.5M, Net Income -$111.6M, EPS $-0.96. Year 2025: Revenue $9.8M, Net Income -$89.3M, EPS $-0.36.
Revenue
Net Income
EPS (right axis)

5-Year Trend Summary: Taysha Gene Therapies, Inc.'s revenue has grown significantly by 291% over the 5-year period, indicating strong business expansion. The most recent EPS of $-0.36 indicates the company is currently unprofitable.

TSHA Revenue Growth, EPS Growth & YoY Performance

Revenue Growth
N/A
Year-over-year
Net Income Growth
N/A
Year-over-year
EPS Growth
N/A
Earnings per share
FCF Margin
-960.1%
Free cash flow / Revenue

TSHA Quarterly Earnings & Performance

Quarterly financial performance data for Taysha Gene Therapies, Inc. including revenue, net income, and earnings per share.
Quarter Revenue Net Income EPS
Q3 2025 N/A -$25.5M $-0.09
Q2 2025 $1.1M -$20.9M $-0.09
Q1 2025 $2.3M -$21.5M $-0.08
Q3 2024 $1.8M -$25.5M $-0.10
Q2 2024 $1.1M -$20.9M $-0.09
Q1 2024 $3.4M -$17.6M $-0.10
Q3 2023 $4.7M -$26.5M $-0.65
Q2 2023 $2.4M -$24.6M $-0.38

Data sourced from SEC EDGAR 10-Q quarterly filings. Figures may represent quarterly or cumulative values.

Taysha Gene Therapies, Inc. Dividends, Buybacks & Capital Allocation

Operating Cash Flow
-$93.1M
Cash generated from operations
Capital Expenditures
$738.0K
Investment in assets
Dividends
None
No dividend program

TSHA SEC Filings: Latest 10-K & 10-Q Analysis

Access official SEC EDGAR filings for Taysha Gene Therapies, Inc. (CIK: 0001806310)

📋 Recent SEC Filings

Date Form Document Action
Apr 13, 2026 4 xslF345X06/form4-04132026_080454.xml View →
Mar 19, 2026 10-K tsha-20251231.htm View →
Mar 19, 2026 8-K d46409d8k.htm View →
Feb 6, 2026 4 xslF345X05/form4-02062026_040223.xml View →
Jan 27, 2026 4 xslF345X05/form4-01272026_040105.xml View →

Frequently Asked Questions about TSHA

What is the AI rating for TSHA?

Taysha Gene Therapies, Inc. (TSHA) has an AI rating of SELL with 72% confidence, based on fundamental analysis of SEC EDGAR filings.

What are TSHA's key strengths?

Claude: Strong balance sheet with $319.8M cash providing 3+ years operational runway. Low leverage (Debt/Equity 0.20x) and minimal debt burden of $50.1M.

What are the risks of investing in TSHA?

Claude: Extreme operating losses (-$110.5M) and negative operating margin (-1130.6%) unsustainable long-term. Annual free cash burn of $93.8M will exhaust cash reserves in 3.4 years without profitability inflection.

What is TSHA's revenue and growth?

Taysha Gene Therapies, Inc. reported revenue of $9.8M.

Does TSHA pay dividends?

Taysha Gene Therapies, Inc. does not currently pay dividends.

Where can I find TSHA SEC filings?

Official SEC filings for Taysha Gene Therapies, Inc. (CIK: 0001806310) including 10-K, 10-Q, and 8-K reports are available on SEC EDGAR.

What is TSHA's EPS?

Taysha Gene Therapies, Inc. has a diluted EPS of $-0.34.

How is the AI analysis conducted?

Two independent AI systems — Claude (Anthropic) and ChatGPT (OpenAI) — analyze SEC EDGAR filings including 10-K annual reports and 10-Q quarterly reports. Each AI evaluates financial health, profitability ratios, balance sheet strength, and growth metrics. The combined rating reflects both perspectives for balanced insights.

Is TSHA a good stock to buy right now?

Based on our AI fundamental analysis in April 2026, Taysha Gene Therapies, Inc. has a SELL rating with 72% confidence. Review the strengths and risks sections above before making a decision. This is not investment advice.

Is TSHA stock overvalued or undervalued?

Valuation metrics for TSHA: ROE of -44.1% (sector avg: 15%), net margin of -1,115.3% (sector avg: 12%). Compare these metrics with sector averages to assess valuation.

Should I buy TSHA stock in 2026?

Our dual AI analysis gives Taysha Gene Therapies, Inc. a combined SELL rating for 2026. Revenue is data pending, with profitability at or below sector average. Always conduct your own research.

What is TSHA's free cash flow?

Taysha Gene Therapies, Inc.'s operating cash flow is $-93.1M, with capital expenditures of $738.0K. FCF margin is -960.1%.

How does TSHA compare to other Healthcare stocks?

Vs Healthcare sector averages: Net margin -1,115.3% (avg: 12%), ROE -44.1% (avg: 15%), current ratio 12.23 (avg: 2).

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Disclaimer: This analysis is generated by Claude AI (Anthropic) and ChatGPT (OpenAI) based on publicly available SEC EDGAR filings. It does not include stock price data and should not be considered financial advice. All fundamental data is sourced from SEC public domain filings. Always conduct your own research and consult with a qualified financial advisor before making investment decisions.
Data Source: SEC EDGAR | Analysis Date: Apr 17, 2026 | Data as of: 2025-12-31 | Powered by Claude AI