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Stoke Therapeutics, Inc. (STOK) Fundamental Analysis & AI Grade 2026

STOK Nasdaq Pharmaceutical Preparations DE CIK: 0001623526
Update Pending • Analysis: May 9, 2026 • SEC Data: 2026-03-31
Combined AI Grade
C
70% Confidence
N/A
C
70% Conf
Pending
Analysis scheduled

📊 STOK Key Takeaways

Revenue: $6.2M
Net Margin: -802.7%
Free Cash Flow: $-60.9M
Current Ratio: 8.99x
Debt/Equity: 0.00x
EPS: $-0.79
AI Grade: C with 70% confidence
Stoke Therapeutics, Inc. (STOK) receives a C fundamental grade with 70% confidence from our AI analysis based on SEC 10-K filings. With revenue of $6.2M, net profit margin of -802.7%, and return on equity (ROE) of -12.7%, Stoke Therapeutics, Inc. demonstrates mixed fundamentals in the Healthcare sector. Below is our complete STOK stock analysis for 2026.

Is Stoke Therapeutics, Inc. (STOK) a Good Investment?

Claude

Stoke Therapeutics demonstrates early revenue traction (+404.5% YoY) and maintains a fortress balance sheet with zero debt and $155.7M cash, but faces a critical challenge: annual operating losses of $53.4M with only ~2.5 years of cash runway at current burn rates. The company must achieve significant revenue inflection or major profitability improvements within this window, or face forced equity dilution and potential strategic alternatives.

Stoke Therapeutics, Inc. Key Strengths (STOK)

Claude
  • + Exceptional revenue growth (404.5% YoY) indicating product market traction
  • + Fortress balance sheet with zero debt, $394.9M equity, and 8.99x current ratio providing financial flexibility
  • + Adequate near-term liquidity (~$155.7M cash) with low leverage profile typical of well-capitalized biotech

STOK Stock Risks: Stoke Therapeutics, Inc. Investment Risks

Claude
  • ! Severe unprofitability with -$802.7% net margin and -$60.6M annual operating cash burn limiting runway to ~2.5 years
  • ! Limited revenue base ($6.2M) insufficient to offset operating expenses, requiring major scale-up or path to profitability is unclear
  • ! Likely future capital dilution needed to extend runway, absent substantial revenue inflection or strategic partnerships reducing burn rate

Key Metrics to Watch

Claude
  • * Operating cash burn rate trend and months of cash runway remaining
  • * Revenue growth trajectory and gross margin as product scales
  • * Achievement of clinical/regulatory milestones that could trigger partnerships or reduce cash burn requirements

Stoke Therapeutics, Inc. (STOK) Financial Metrics & Key Ratios

Revenue
$6.2M
Net Income
$-50.0M
EPS (Diluted)
$-0.79
Free Cash Flow
$-60.9M
Total Assets
$443.3M
Cash Position
$155.7M

💡 AI Analyst Insight

Strong liquidity with a 8.99x current ratio provides a solid financial cushion.

STOK Profit Margin, ROE & Profitability Analysis

Gross Margin N/A
Operating Margin -857.6%
Net Margin -802.7%
ROE -12.7%
ROA -11.3%
FCF Margin -978.2%

STOK vs Healthcare Sector: How Stoke Therapeutics, Inc. Compares

How Stoke Therapeutics, Inc. compares to Healthcare sector averages

Net Margin
STOK -802.7%
vs
Sector Avg 12.0%
STOK Sector
ROE
STOK -12.7%
vs
Sector Avg 15.0%
STOK Sector
Current Ratio
STOK 9.0x
vs
Sector Avg 2.0x
STOK Sector
Debt/Equity
STOK 0.0x
vs
Sector Avg 0.6x
STOK Sector

Sector benchmarks are approximate industry averages. Actual sector performance may vary.

Is Stoke Therapeutics, Inc. Stock Overvalued? STOK Valuation Analysis 2026

Based on fundamental analysis, Stoke Therapeutics, Inc. has mixed fundamental signals relative to the Healthcare sector in 2026.

Return on Equity
-12.7%
Sector avg: 15%
Net Profit Margin
-802.7%
Sector avg: 12%
Revenue Growth
N/A
Year-over-year
Debt/Equity
0.00x
Sector avg: 0.6x

Note: This is a fundamental analysis based on SEC filings. For P/E ratio, price targets, and market-based valuation, consult financial data providers. This is not investment advice.

Stoke Therapeutics, Inc. Balance Sheet: STOK Debt, Cash & Liquidity

Current Ratio
8.99x
Quick Ratio
8.99x
Debt/Equity
0.00x
Debt/Assets
10.9%
Interest Coverage
-2,322.52x
Long-term Debt
N/A

STOK Revenue & Earnings Growth: 5-Year Financial Trend

STOK 5-year financial data: Year 2022: Revenue $12.4M, Net Income -$85.8M, EPS $-2.34. Year 2023: Revenue $12.4M, Net Income -$101.1M, EPS $-2.60. Year 2024: Revenue $36.6M, Net Income -$104.7M, EPS $-2.38. Year 2025: Revenue $184.4M, Net Income -$89.0M, EPS $-1.65.
Revenue
Net Income
EPS (right axis)

5-Year Trend Summary: Stoke Therapeutics, Inc.'s revenue has grown significantly by 1,387% over the 5-year period, indicating strong business expansion. The most recent EPS of $-1.65 indicates the company is currently unprofitable.

STOK Revenue Growth, EPS Growth & YoY Performance

Revenue Growth
N/A
Year-over-year
Net Income Growth
N/A
Year-over-year
EPS Growth
N/A
Earnings per share
FCF Margin
-978.2%
Free cash flow / Revenue

STOK Quarterly Earnings & Performance

Quarterly financial performance data for Stoke Therapeutics, Inc. including revenue, net income, and earnings per share.
Quarter Revenue Net Income EPS
Q1 2026 $6.2M -$50.0M $-0.79
Q3 2025 $4.9M -$23.5M $-0.47
Q2 2025 $4.8M -$23.5M $-0.40
Q1 2025 $4.2M -$26.4M $-0.57
Q3 2024 $3.3M -$22.5M $-0.47
Q2 2024 -$2.5M -$22.5M $-0.46
Q1 2024 $4.2M -$22.5M $-0.53
Q3 2023 $2.9M -$22.5M $-0.55

Data sourced from SEC EDGAR 10-Q quarterly filings. Figures may represent quarterly or cumulative values.

Stoke Therapeutics, Inc. Dividends, Buybacks & Capital Allocation

Operating Cash Flow
-$60.6M
Cash generated from operations
Capital Expenditures
$353.0K
Investment in assets
Dividends
None
No dividend program

STOK SEC Filings: Latest 10-K & 10-Q Analysis

Access official SEC EDGAR filings for Stoke Therapeutics, Inc. (CIK: 0001623526)

📋 Recent SEC Filings

Date Form Document Action
Jun 5, 2026 4 xslF345X06/form4-06052026_080612.xml View →
Jun 5, 2026 4 xslF345X06/form4-06052026_080637.xml View →
Jun 5, 2026 4 xslF345X06/form4-06052026_080631.xml View →
Jun 5, 2026 4 xslF345X06/form4-06052026_080620.xml View →
Jun 5, 2026 4 xslF345X06/form4-06052026_080652.xml View →

Frequently Asked Questions about STOK

What is the AI rating for STOK?

Stoke Therapeutics, Inc. (STOK) has an AI grade of C with 70% confidence, based on fundamental analysis of SEC EDGAR filings.

What are STOK's key strengths?

Claude: Exceptional revenue growth (404.5% YoY) indicating product market traction. Fortress balance sheet with zero debt, $394.9M equity, and 8.99x current ratio providing financial flexibility.

What are the risks of investing in STOK?

Claude: Severe unprofitability with -$802.7% net margin and -$60.6M annual operating cash burn limiting runway to ~2.5 years. Limited revenue base ($6.2M) insufficient to offset operating expenses, requiring major scale-up or path to profitability is unclear.

What is STOK's revenue and growth?

Stoke Therapeutics, Inc. reported revenue of $6.2M.

Does STOK pay dividends?

Stoke Therapeutics, Inc. does not currently pay dividends.

Where can I find STOK SEC filings?

Official SEC filings for Stoke Therapeutics, Inc. (CIK: 0001623526) including 10-K, 10-Q, and 8-K reports are available on SEC EDGAR.

What is STOK's EPS?

Stoke Therapeutics, Inc. has a diluted EPS of $-0.79.

How is the AI analysis conducted?

Two independent AI systems — Claude (Anthropic) and ChatGPT (OpenAI) — analyze SEC EDGAR filings including 10-K annual reports and 10-Q quarterly reports. Each AI evaluates financial health, profitability ratios, balance sheet strength, and growth metrics. The combined grade reflects both perspectives for balanced insights.

What is STOK's fundamental grade?

Based on our AI fundamental analysis in June 2026, Stoke Therapeutics, Inc. has a C grade with 70% confidence. Review the strengths and risks sections above for full context. This is not investment advice.

Is STOK stock overvalued or undervalued?

Valuation metrics for STOK: ROE of -12.7% (sector avg: 15%), net margin of -802.7% (sector avg: 12%). Compare these metrics with sector averages to assess valuation.

What is STOK's AI grade for 2026?

Our dual AI analysis gives Stoke Therapeutics, Inc. a combined C grade for 2026. Revenue is data pending, with profitability at or below sector average. Always conduct your own research.

What is STOK's free cash flow?

Stoke Therapeutics, Inc.'s operating cash flow is $-60.6M, with capital expenditures of $353.0K. FCF margin is -978.2%.

How does STOK compare to other Healthcare stocks?

Vs Healthcare sector averages: Net margin -802.7% (avg: 12%), ROE -12.7% (avg: 15%), current ratio 8.99 (avg: 2).

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Disclaimer: This analysis is generated by Claude AI (Anthropic) and ChatGPT (OpenAI) based on publicly available SEC EDGAR filings. It does not include stock price data and should not be considered financial advice. All fundamental data is sourced from SEC public domain filings. Always conduct your own research and consult with a qualified financial advisor before making investment decisions.
Data Source: SEC EDGAR | Analysis Date: May 9, 2026 | Data as of: 2026-03-31 | Powered by Claude AI