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Orchestra BioMed Holdings, Inc. (OBIO) Fundamental Analysis & AI Grade 2026

OBIO Nasdaq Surgical & Medical Instruments & Apparatus DE CIK: 0001814114
Updated This Month • Analysis: May 13, 2026 • SEC Data: 2026-03-31
Combined AI Grade
C
74% Confidence
STRONG AGREEMENT
C
78% Conf
C
70% Conf

📊 OBIO Key Takeaways

Revenue: $110.0K
Net Margin: -18,810.0%
Free Cash Flow: $-22.4M
Current Ratio: 7.03x
Debt/Equity: 0.36x
EPS: $-0.33
AI Grade: C with 78% confidence
Orchestra BioMed Holdings, Inc. (OBIO) receives a C fundamental grade with 74% confidence from our AI analysis based on SEC 10-K filings. With revenue of $110.0K, net profit margin of -18,810.0%, and return on equity (ROE) of -50.2%, Orchestra BioMed Holdings, Inc. demonstrates mixed fundamentals in the Healthcare sector. Below is our complete OBIO stock analysis for 2026.

Is Orchestra BioMed Holdings, Inc. (OBIO) a Good Investment?

Claude

Orchestra BioMed is a pre-commercial stage medical device company burning $22.2M annually on $110K revenue, indicating severe unit economics and no clear path to profitability. While the company maintains adequate liquidity ($28.4M cash) with reasonable leverage (0.36x Debt/Equity), current burn rate depletes cash reserves in approximately 1.3 years without significant revenue acceleration or cost reduction.

ChatGPT

OBIO shows extraordinary top-line growth but remains deeply unprofitable, with triple-digit negative operating and net margins and severely negative returns on capital. Liquidity is currently solid and leverage is low, but operating cash burn far outpaces cash on hand, implying a short runway and likely need for external financing. Until revenue quality proves durable and losses narrow materially, fundamentals skew unfavorable.

Orchestra BioMed Holdings, Inc. Key Strengths (OBIO)

Claude
  • + Strong liquidity position with 7.03x current ratio and $28.4M cash
  • + Controlled debt levels at 0.36x Debt/Equity ratio limiting financial distress risk
  • + Extreme revenue growth of 1169% YoY suggests early commercialization traction, though from minimal base
ChatGPT
  • + Strong liquidity with very high current and quick ratios
  • + Low leverage (D/E 0.28x) and minimal capex needs
  • + Significant YoY revenue growth providing potential scale platform

OBIO Stock Risks: Orchestra BioMed Holdings, Inc. Investment Risks

Claude
  • ! Severe cash burn of $22.2M annually against $110K revenue demonstrates unsustainable unit economics
  • ! Negative operating margin of -20069% and negative free cash flow indicates company is pre-profitability with no visibility to breakeven
  • ! Limited cash runway of approximately 1.3 years at current burn rate without achieving significant revenue growth or cost controls
  • ! Missing gross profit data suggests potential product or operational reporting issues
ChatGPT
  • ! Persistent, large operating and net losses with highly negative margins
  • ! Heavy cash burn versus cash balance, implying financing/dilution risk
  • ! Revenue sustainability concerns given spike and lack of gross margin clarity

Key Metrics to Watch

Claude
  • * Quarterly revenue growth trajectory and achievement of $1M+ quarterly revenue milestone
  • * Operating cash burn rate and path to cash flow breakeven
  • * Gross margin visibility and achievement of positive contribution margins by product
ChatGPT
  • * Operating cash flow (quarterly)
  • * Cash & equivalents (runway months)

Orchestra BioMed Holdings, Inc. (OBIO) Financial Metrics & Key Ratios

Revenue
$110.0K
Net Income
$-20.7M
EPS (Diluted)
$-0.33
Free Cash Flow
$-22.4M
Total Assets
$100.7M
Cash Position
$28.4M

💡 AI Analyst Insight

Strong liquidity with a 7.03x current ratio provides a solid financial cushion.

OBIO Profit Margin, ROE & Profitability Analysis

Gross Margin N/A
Operating Margin -20,069.1%
Net Margin -18,810.0%
ROE -50.2%
ROA -20.6%
FCF Margin -20,320.0%

OBIO vs Healthcare Sector: How Orchestra BioMed Holdings, Inc. Compares

How Orchestra BioMed Holdings, Inc. compares to Healthcare sector averages

Net Margin
OBIO -18,810.0%
vs
Sector Avg 12.0%
OBIO Sector
ROE
OBIO -50.2%
vs
Sector Avg 15.0%
OBIO Sector
Current Ratio
OBIO 7.0x
vs
Sector Avg 2.0x
OBIO Sector
Debt/Equity
OBIO 0.4x
vs
Sector Avg 0.6x
OBIO Sector

Sector benchmarks are approximate industry averages. Actual sector performance may vary.

Is Orchestra BioMed Holdings, Inc. Stock Overvalued? OBIO Valuation Analysis 2026

Based on fundamental analysis, Orchestra BioMed Holdings, Inc. has mixed fundamental signals relative to the Healthcare sector in 2026.

Return on Equity
-50.2%
Sector avg: 15%
Net Profit Margin
-18,810.0%
Sector avg: 12%
Revenue Growth
N/A
Year-over-year
Debt/Equity
0.36x
Sector avg: 0.6x

Note: This is a fundamental analysis based on SEC filings. For P/E ratio, price targets, and market-based valuation, consult financial data providers. This is not investment advice.

Orchestra BioMed Holdings, Inc. Balance Sheet: OBIO Debt, Cash & Liquidity

Current Ratio
7.03x
Quick Ratio
7.01x
Debt/Equity
0.36x
Debt/Assets
49.4%
Interest Coverage
-74.33x
Long-term Debt
$15.0M

OBIO Revenue & Earnings Growth: 5-Year Financial Trend

OBIO 5-year financial data: Year 2023: Revenue $3.5M, Net Income -$33.6M, EPS $-2.24. Year 2024: Revenue $2.8M, Net Income -$49.1M, EPS $-1.48. Year 2025: Revenue $33.5M, Net Income -$61.0M, EPS $-1.66.
Revenue
Net Income
EPS (right axis)

5-Year Trend Summary: Orchestra BioMed Holdings, Inc.'s revenue has grown significantly by 848% over the 5-year period, indicating strong business expansion. The most recent EPS of $-1.66 indicates the company is currently unprofitable.

OBIO Revenue Growth, EPS Growth & YoY Performance

Revenue Growth
N/A
Year-over-year
Net Income Growth
N/A
Year-over-year
EPS Growth
N/A
Earnings per share
FCF Margin
-20,320.0%
Free cash flow / Revenue

OBIO Quarterly Earnings & Performance

Quarterly financial performance data for Orchestra BioMed Holdings, Inc. including revenue, net income, and earnings per share.
Quarter Revenue Net Income EPS
Q1 2026 $110.0K -$18.8M $-0.33
Q3 2025 $861.0K -$13.5M $-0.40
Q2 2025 $778.0K -$13.5M $-0.45
Q1 2025 $620.0K -$13.5M $-0.38
Q3 2024 $419.0K -$10.9M $-0.38
Q2 2024 $778.0K -$10.9M $-0.35
Q1 2024 $620.0K -$10.9M $-0.38
Q3 2023 $419.0K -$5.7M $-0.38

Data sourced from SEC EDGAR 10-Q quarterly filings. Figures may represent quarterly or cumulative values.

Orchestra BioMed Holdings, Inc. Dividends, Buybacks & Capital Allocation

Operating Cash Flow
-$22.2M
Cash generated from operations
Capital Expenditures
$184.0K
Investment in assets
Dividends
None
No dividend program

OBIO SEC Filings: Latest 10-K & 10-Q Analysis

Access official SEC EDGAR filings for Orchestra BioMed Holdings, Inc. (CIK: 0001814114)

📋 Recent SEC Filings

Date Form Document Action
Jun 2, 2026 4 xslF345X06/tm2616712-2_4seq1.xml View →
Jun 2, 2026 4 xslF345X06/tm2616712-1_4seq1.xml View →
May 29, 2026 4 xslF345X06/tm2616050-2_4seq1.xml View →
May 29, 2026 4 xslF345X06/tm2616050-1_4seq1.xml View →
May 20, 2026 4 xslF345X06/tm2615140-1_4seq1.xml View →

Frequently Asked Questions about OBIO

What is the AI rating for OBIO?

Orchestra BioMed Holdings, Inc. (OBIO) has a Combined AI Grade of C from Claude (C) and ChatGPT (C) with 74% combined confidence, based on fundamental analysis of SEC EDGAR filings.

What are OBIO's key strengths?

Claude: Strong liquidity position with 7.03x current ratio and $28.4M cash. Controlled debt levels at 0.36x Debt/Equity ratio limiting financial distress risk. ChatGPT: Strong liquidity with very high current and quick ratios. Low leverage (D/E 0.28x) and minimal capex needs.

What are the risks of investing in OBIO?

Claude: Severe cash burn of $22.2M annually against $110K revenue demonstrates unsustainable unit economics. Negative operating margin of -20069% and negative free cash flow indicates company is pre-profitability with no visibility to breakeven. ChatGPT: Persistent, large operating and net losses with highly negative margins. Heavy cash burn versus cash balance, implying financing/dilution risk.

What is OBIO's revenue and growth?

Orchestra BioMed Holdings, Inc. reported revenue of $110.0K.

Does OBIO pay dividends?

Orchestra BioMed Holdings, Inc. does not currently pay dividends.

Where can I find OBIO SEC filings?

Official SEC filings for Orchestra BioMed Holdings, Inc. (CIK: 0001814114) including 10-K, 10-Q, and 8-K reports are available on SEC EDGAR.

What is OBIO's EPS?

Orchestra BioMed Holdings, Inc. has a diluted EPS of $-0.33.

How is the AI analysis conducted?

Two independent AI systems — Claude (Anthropic) and ChatGPT (OpenAI) — analyze SEC EDGAR filings including 10-K annual reports and 10-Q quarterly reports. Each AI evaluates financial health, profitability ratios, balance sheet strength, and growth metrics. The combined grade reflects both perspectives for balanced insights.

What is OBIO's fundamental grade?

Based on our AI fundamental analysis in June 2026, Orchestra BioMed Holdings, Inc. has a C grade with 74% confidence. Review the strengths and risks sections above for full context. This is not investment advice.

Is OBIO stock overvalued or undervalued?

Valuation metrics for OBIO: ROE of -50.2% (sector avg: 15%), net margin of -18,810.0% (sector avg: 12%). Compare these metrics with sector averages to assess valuation.

What is OBIO's AI grade for 2026?

Our dual AI analysis gives Orchestra BioMed Holdings, Inc. a combined C grade for 2026. Revenue is data pending, with profitability at or below sector average. Always conduct your own research.

What is OBIO's free cash flow?

Orchestra BioMed Holdings, Inc.'s operating cash flow is $-22.2M, with capital expenditures of $184.0K. FCF margin is -20,320.0%.

How does OBIO compare to other Healthcare stocks?

Vs Healthcare sector averages: Net margin -18,810.0% (avg: 12%), ROE -50.2% (avg: 15%), current ratio 7.03 (avg: 2).

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Disclaimer: This analysis is generated by Claude AI (Anthropic) and ChatGPT (OpenAI) based on publicly available SEC EDGAR filings. It does not include stock price data and should not be considered financial advice. All fundamental data is sourced from SEC public domain filings. Always conduct your own research and consult with a qualified financial advisor before making investment decisions.
Data Source: SEC EDGAR | Analysis Date: May 13, 2026 | Data as of: 2026-03-31 | Powered by Claude AI