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CRISPR Therapeutics AG (CRSP) Stock Fundamental Analysis & AI Rating 2026

CRSP Nasdaq Biological Products, (No Diagnostic Substances) V8 CIK: 0001674416
Recently Updated • Analysis: May 7, 2026 • SEC Data: 2026-03-31
Combined AI Rating
SELL
72% Confidence
NEUTRAL
STRONG SELL
70% Conf
HOLD
73% Conf

📊 CRSP Key Takeaways

Revenue: $1.5M
Net Margin: -8,431.5%
Free Cash Flow: $-109.4M
Current Ratio: 17.96x
Debt/Equity: 0.32x
EPS: $-1.28
AI Rating: STRONG SELL with 70% confidence
CRISPR Therapeutics AG (CRSP) receives a SELL rating with 72% confidence from our AI fundamental analysis based on SEC 10-K filings. With revenue of $1.5M, net profit margin of -8,431.5%, and return on equity (ROE) of -6.8%, CRISPR Therapeutics AG demonstrates mixed fundamentals in the Healthcare sector. Below is our complete CRSP stock analysis for 2026.

Is CRISPR Therapeutics AG (CRSP) a Good Investment?

Claude

CRISPR Therapeutics faces critical operational deterioration with revenue collapsing 90.6% YoY to $1.5M while sustaining -$130.2M operating losses and burning -$109.4M in free cash flow annually. Despite a fortress balance sheet providing estimated 4-5 year runway, the company shows no profitability trajectory and is rapidly consuming shareholder capital with negative margins exceeding -8400%.

ChatGPT

CRISPR Therapeutics' fundamentals show a classic development-stage biotech profile: minimal and highly volatile revenue, very large operating losses, and deeply negative free cash flow. The main offset is an exceptionally strong balance sheet, with substantial cash, no meaningful long-term debt, and very high liquidity, which gives the company time to fund R&D and absorb commercialization delays. Fundamental upside depends less on current earnings quality and more on whether revenue becomes durable while cash burn narrows.

Why Buy CRISPR Therapeutics AG Stock? CRSP Key Strengths

Claude
  • + Exceptional liquidity position with 17.96x current ratio and $423.3M cash providing multi-year operational runway
  • + Conservative leverage at 0.32x debt-to-equity with manageable $585.5M long-term debt
  • + Substantial $2.7B asset base and $1.8B stockholders' equity provides financial flexibility
ChatGPT
  • + Very strong liquidity profile, with cash of $347.56M and current and quick ratios of 13.32x
  • + Debt-free balance sheet and $1.92B equity base provide financial flexibility
  • + Large asset base relative to liabilities reduces near-term solvency pressure

CRSP Stock Risks: CRISPR Therapeutics AG Investment Risks

Claude
  • ! Revenue collapse of 90.6% YoY to $1.5M signals severe loss of revenue stream or major contract termination
  • ! Negative free cash flow of -$109.4M annually with no visible path to cash flow breakeven
  • ! Operating losses of -$130.2M require successful clinical breakthroughs or external financing within finite cash runway
ChatGPT
  • ! Revenue fell 90.6% year over year, indicating weak revenue durability and poor growth quality
  • ! Operating loss of $664.57M and net loss of $581.60M reflect an unsustainable profitability profile
  • ! Negative operating cash flow of $345.01M shows continued heavy cash consumption that could pressure future funding needs

Key Metrics to Watch

Claude
  • * Quarterly revenue stabilization and new partnership/contract announcements
  • * Operating cash flow recovery trajectory and monthly burn rate trends
  • * Clinical trial advancement milestones and regulatory approval progress
  • * Cash balance depletion rate and need for equity or debt financing
ChatGPT
  • * Quarterly revenue consistency and commercialization-related revenue growth
  • * Operating cash burn relative to cash and equivalents

CRISPR Therapeutics AG (CRSP) Financial Metrics & Key Ratios

Revenue
$1.5M
Net Income
$-122.9M
EPS (Diluted)
$-1.28
Free Cash Flow
$-109.4M
Total Assets
$2.7B
Cash Position
$423.3M

💡 AI Analyst Insight

Strong liquidity with a 17.96x current ratio provides a solid financial cushion.

CRSP Profit Margin, ROE & Profitability Analysis

Gross Margin N/A
Operating Margin -8,933.3%
Net Margin -8,431.5%
ROE -6.8%
ROA -4.5%
FCF Margin -7,503.5%

CRSP vs Healthcare Sector: How CRISPR Therapeutics AG Compares

How CRISPR Therapeutics AG compares to Healthcare sector averages

Net Margin
CRSP -8,431.5%
vs
Sector Avg 12.0%
CRSP Sector
ROE
CRSP -6.8%
vs
Sector Avg 15.0%
CRSP Sector
Current Ratio
CRSP 18.0x
vs
Sector Avg 2.0x
CRSP Sector
Debt/Equity
CRSP 0.3x
vs
Sector Avg 0.6x
CRSP Sector

Sector benchmarks are approximate industry averages. Actual sector performance may vary.

Is CRISPR Therapeutics AG Stock Overvalued? CRSP Valuation Analysis 2026

Based on fundamental analysis, CRISPR Therapeutics AG has mixed fundamental signals relative to the Healthcare sector in 2026.

Return on Equity
-6.8%
Sector avg: 15%
Net Profit Margin
-8,431.5%
Sector avg: 12%
Revenue Growth
N/A
Year-over-year
Debt/Equity
0.32x
Sector avg: 0.6x

Note: This is a fundamental analysis based on SEC filings. For P/E ratio, price targets, and market-based valuation, consult financial data providers. This is not investment advice.

CRISPR Therapeutics AG Balance Sheet: CRSP Debt, Cash & Liquidity

Current Ratio
17.96x
Quick Ratio
17.96x
Debt/Equity
0.32x
Debt/Assets
33.4%
Interest Coverage
-235.53x
Long-term Debt
$585.5M

CRSP Revenue & Earnings Growth: 5-Year Financial Trend

CRSP 5-year financial data: Year 2021: Revenue $915.0M, Net Income $66.9M, EPS $1.17. Year 2022: Revenue $915.0M, Net Income -$348.9M, EPS $-5.29. Year 2023: Revenue $915.0M, Net Income $377.7M, EPS $4.70. Year 2024: Revenue $371.2M, Net Income -$650.2M, EPS $-8.36. Year 2025: Revenue $371.2M, Net Income -$153.6M, EPS $-1.94.
Revenue
Net Income
EPS (right axis)

5-Year Trend Summary: CRISPR Therapeutics AG's revenue has declined by 59% over the 5-year period, indicating business contraction. The most recent EPS of $-1.94 indicates the company is currently unprofitable.

CRSP Revenue Growth, EPS Growth & YoY Performance

Revenue Growth
N/A
Year-over-year
Net Income Growth
N/A
Year-over-year
EPS Growth
N/A
Earnings per share
FCF Margin
-7,503.5%
Free cash flow / Revenue

CRSP Quarterly Earnings & Performance

Quarterly financial performance data for CRISPR Therapeutics AG including revenue, net income, and earnings per share.
Quarter Revenue Net Income EPS
Q1 2026 $865.0K -$122.9M $-1.28
Q3 2025 $602.0K -$85.9M $-1.01
Q2 2025 $517.0K -$116.6M $-1.49
Q1 2025 $504.0K -$116.6M $-1.43
Q3 2024 N/A -$53.1M $-1.01
Q2 2024 $517.0K -$53.1M $-0.98
Q1 2024 $504.0K -$53.1M $-0.67
Q3 2023 N/A -$53.1M $-1.41

Data sourced from SEC EDGAR 10-Q quarterly filings. Figures may represent quarterly or cumulative values.

CRISPR Therapeutics AG Dividends, Buybacks & Capital Allocation

Operating Cash Flow
-$108.9M
Cash generated from operations
Stock Buybacks
$57.0K
Shares repurchased (TTM)
Capital Expenditures
$504.0K
Investment in assets
Dividends
None
No dividend program

CRSP SEC Filings: Latest 10-K & 10-Q Analysis

Access official SEC EDGAR filings for CRISPR Therapeutics AG (CIK: 0001674416)

📋 Recent SEC Filings

Date Form Document Action
May 4, 2026 10-Q crsp-20260331.htm View →
May 4, 2026 8-K crsp-20260504.htm View →
Apr 21, 2026 DEF 14A crsp-20260421.htm View →
Mar 24, 2026 4 xslF345X06/ownership.xml View →
Mar 24, 2026 4 xslF345X06/ownership.xml View →

Frequently Asked Questions about CRSP

What is the AI rating for CRSP?

CRISPR Therapeutics AG (CRSP) has a Combined AI Rating of SELL from Claude (STRONG SELL) and ChatGPT (HOLD) with 72% combined confidence, based on fundamental analysis of SEC EDGAR filings.

What are CRSP's key strengths?

Claude: Exceptional liquidity position with 17.96x current ratio and $423.3M cash providing multi-year operational runway. Conservative leverage at 0.32x debt-to-equity with manageable $585.5M long-term debt. ChatGPT: Very strong liquidity profile, with cash of $347.56M and current and quick ratios of 13.32x. Debt-free balance sheet and $1.92B equity base provide financial flexibility.

What are the risks of investing in CRSP?

Claude: Revenue collapse of 90.6% YoY to $1.5M signals severe loss of revenue stream or major contract termination. Negative free cash flow of -$109.4M annually with no visible path to cash flow breakeven. ChatGPT: Revenue fell 90.6% year over year, indicating weak revenue durability and poor growth quality. Operating loss of $664.57M and net loss of $581.60M reflect an unsustainable profitability profile.

What is CRSP's revenue and growth?

CRISPR Therapeutics AG reported revenue of $1.5M.

Does CRSP pay dividends?

CRISPR Therapeutics AG does not currently pay dividends.

Where can I find CRSP SEC filings?

Official SEC filings for CRISPR Therapeutics AG (CIK: 0001674416) including 10-K, 10-Q, and 8-K reports are available on SEC EDGAR.

What is CRSP's EPS?

CRISPR Therapeutics AG has a diluted EPS of $-1.28.

How is the AI analysis conducted?

Two independent AI systems — Claude (Anthropic) and ChatGPT (OpenAI) — analyze SEC EDGAR filings including 10-K annual reports and 10-Q quarterly reports. Each AI evaluates financial health, profitability ratios, balance sheet strength, and growth metrics. The combined rating reflects both perspectives for balanced insights.

Is CRSP a good stock to buy right now?

Based on our AI fundamental analysis in May 2026, CRISPR Therapeutics AG has a SELL rating with 72% confidence. Review the strengths and risks sections above before making a decision. This is not investment advice.

Is CRSP stock overvalued or undervalued?

Valuation metrics for CRSP: ROE of -6.8% (sector avg: 15%), net margin of -8,431.5% (sector avg: 12%). Compare these metrics with sector averages to assess valuation.

Should I buy CRSP stock in 2026?

Our dual AI analysis gives CRISPR Therapeutics AG a combined SELL rating for 2026. Revenue is data pending, with profitability at or below sector average. Always conduct your own research.

What is CRSP's free cash flow?

CRISPR Therapeutics AG's operating cash flow is $-108.9M, with capital expenditures of $504.0K. FCF margin is -7,503.5%.

How does CRSP compare to other Healthcare stocks?

Vs Healthcare sector averages: Net margin -8,431.5% (avg: 12%), ROE -6.8% (avg: 15%), current ratio 17.96 (avg: 2).

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Disclaimer: This analysis is generated by Claude AI (Anthropic) and ChatGPT (OpenAI) based on publicly available SEC EDGAR filings. It does not include stock price data and should not be considered financial advice. All fundamental data is sourced from SEC public domain filings. Always conduct your own research and consult with a qualified financial advisor before making investment decisions.
Data Source: SEC EDGAR | Analysis Date: May 7, 2026 | Data as of: 2026-03-31 | Powered by Claude AI